Article
Agronomy
Marcella Whetsell, Edward Rayburn
Summary: This study examined the fatty acid content in different types of pasture grasses, legumes, and non-leguminous forbs in northeast West Virginia. The research found variations in fatty acid content among different plant species, with forbs having the highest linoleic acid content and grasses and forbs having the highest alpha-linolenic acid content. The study also evaluated the correlation between crude protein concentration and fatty acid concentration, and found that the summer months and the presence of forbs affected the alpha-linolenic acid content. Vegetative growth and leafiness were identified as major factors influencing the fatty acid content in pasture forage.
Article
Food Science & Technology
Topi Meuronen, Maria A. Lankinen, Johan Kolmert, Vanessa de Mello Laaksonen, Taisa Sallinen, Jyrki Agren, Kirsi A. Virtanen, Markku Laakso, Craig E. Wheelock, Jussi Pihlajamaki, Ursula Schwab
Summary: This study investigated the interactions between dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS), and found that different genotypes have different effects on plasma lipid fatty acid composition and bioactive lipid mediators. These findings suggest the potential for genotype-based recommendations for PUFA consumption, which can have beneficial effects on health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
Karolina Dec, Mouhamed Alsaqati, Joanne Morgan, Sumukh Deshpande, Jamie Wood, Jeremy Hall, Adrian J. Harwood
Summary: There is no consensus on the treatment length, dosage, and use of specific n-3 polyunsaturated fatty acids in clinical trials and epidemiological studies on children and adults. The aim of this study is to develop a simplified in vitro cell model to investigate the impact of different n-6 to n-3 polyunsaturated fatty acid ratios on human-derived neuron activity and understand their underlying mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiong Wang, Xingguo Wang
Summary: A low intake ratio of linoleic acid/a-linolenic acid (LA/ALA) reduces the risk of obesity and metabolic syndrome. In this study, a high-fat diet with a low LA/ALA ratio (HFD+H3L6) significantly decreased the liver index, as well as levels of triacylglycerols and LDL-C in obese mice. The diet also improved the antioxidant status and reduced inflammation in the liver. Moreover, it altered gene expression related to fatty acid synthesis and regulation, increasing the levels of omega-3 fatty acids. These findings highlight the importance of optimizing dietary fat intake for lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Parisa Hajihashemi, Awat Feizi, Zahra Heidari, Fahimeh Haghighatdoost
Summary: This systematic review and meta-analysis summarizes previous findings on the association between n-6 PUFA levels in diets or blood and blood pressure. The results suggest that higher circulatory/dietary n-6 PUFAs tend to be associated with lower odds of hypertension, specifically total n-6 PUFAs and linoleic acid.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Immunology
Alexandria Lozowchuk, Judith E. Carroll, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Kharah M. Ross
Summary: This study explored the relationship between partner relationship quality and inflammatory markers IL-6, IL-10, and TNF-alpha during pregnancy and the postpartum period. The findings suggest that lower partner support may be associated with reduced inflammation regulation, with potential consequences for maternal health and well-being.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster Jr, Rakesh Patel, Dario A. Vitturi, Bruce A. Freeman, Francisco J. Schopfer
Summary: This study identified nitro-nitrate ester-containing lipids as intermediates in unsaturated fatty acid nitration reactions in rat stomach, leading to the production of anti-inflammatory and tissue-protective signaling mediators. These observations provide new insight into the mechanisms of unsaturated fatty acid nitration and expand the scope of endogenous products resulting from nitrogen oxides metabolic reactions.
Article
Medicine, Research & Experimental
Jun Ji, Xiaoyu Zhao, Jiajun Huang, Xuanqin Wu, Fang Xie, Liang Li, Tao Wang, Shengli Mi
Summary: Diabetic peripheral arterial atherosclerosis is an important characteristic of diabetic foot syndrome. Apolipoprotein (Apo A-IV) plays a role in anti-atherosclerosis, prevention of platelet aggregation, and thrombosis. The glycosylation of Apo A-IV is closely related to the occurrence and development of diabetic peripheral atherosclerosis.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Nanthana Pothakam, Pantaporn Supakankul, Worrarak Norseeda, Guisheng Liu, Tawatchai Teltathum, Watcharapong Naraballobh, Trisadee Khamlor, Korawan Sringarm, Supamit Mekchay
Summary: This study verified the polymorphisms of porcine IL-1A and IL-6 genes and found their associations with intramuscular fat content and fatty acid composition in commercial crossbred pigs. The results indicated that these genes play an important role in lipid content and fatty acid composition in pig muscles, confirming their significance as candidate genes for fatty acid composition.
Article
Endocrinology & Metabolism
Kai Wang, Yueyang Zhong, Fangkun Yang, Chenyang Hu, Xin Liu, Yanan Zhu, Ke Yao
Summary: The study found that circulating linoleic acid (LA) accounted for the protective effects of n-6 PUFAs against age-related macular degeneration (AMD), while arachidonic acid (AA) was associated with an increased risk of AMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kai Wang, Yueyang Zhong, Fangkun Yang, Chenyang Hu, Xin Liu, Yanan Zhu, Ke Yao
Summary: Genetic evidence shows that circulating linoleic acid (LA) is protective against AMD, while circulating arachidonic acid (AA) increases the risk of AMD. The findings are consistent across different analyses, suggesting robust causal associations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)