Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrew Salazar, Joerg von Hagen
Summary: Periodically oscillating biological processes, such as circadian rhythms, play a crucial role in tissue pathology, organismal health, and molecular mechanisms. Recent reports challenge the prevailing hierarchical model by suggesting that light can independently affect peripheral circadian clocks. However, there is a lack of comprehensive overview regarding these processes in the skin. This review highlights the molecular circadian clock machinery and factors governing it, and emphasizes the link between circadian rhythm, immunological processes, and skin homeostasis as well as its impact on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L. Simone
Summary: Disruption of circadian rhythms is linked to the development and radiation response of breast cancer. Molecular alterations in circadian clock regulators may influence cancer phenotypes, outcomes, and radiation response. Exploiting circadian mechanisms can improve the effectiveness of radiation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodriguez-Yanez, Iria Lopez-Dequidt, Jose M. Pumar, Antonio J. Mosqueira, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: The circadian system has an influence on body temperature and stroke onset. This study explores the impact of temperature chronobiology on stroke onset and functional outcomes, as well as the variation of blood biomarkers based on stroke onset time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Bhavana B. Bhat, Chetan H. Mehta, Akhil Suresh, Varalakshmi Velagacherla, Usha Y. Nayak
Summary: This article discusses the impact of circadian rhythms on health and the importance of chronotherapeutic approaches in treating diseases that are influenced by these rhythms.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Andrew D. Beale, Edward A. Hayter, Priya Crosby, Utham K. Valekunja, Rachel S. Edgar, Johanna E. Chesham, Elizabeth S. Maywood, Fatima H. Labeed, Akhilesh B. Reddy, Kenneth P. Wright Jr, Kathryn S. Lilley, David A. Bechtold, Michael H. Hastings, John S. O'Neill
Summary: Cellular circadian rhythms in red blood cells regulate core body temperature and can be modulated by dietary sodium nitrite.
Article
Biochemistry & Molecular Biology
Luba Sominsky, Tamara Dangel, Sajida Malik, Simone N. De Luca, Nicolas Singewald, Sarah J. Spencer
Summary: Microglia play essential roles not only in immune defense but also in regulating satiety, memory, and pain responses. These functions are significantly influenced by circadian rhythmicity, impacting various physiological processes throughout the day.
Article
Cardiac & Cardiovascular Systems
Meghan Prin, Jack Pattee, David J. Douin, Benjamin K. Scott, Adit A. Ginde, Tobias Eckle
Summary: The perioperative administration of midazolam may not pose a significant risk for myocardial injury in patients undergoing non-cardiac surgery (MINS). However, the usage of midazolam at night and in healthier patients could increase the risk of MINS, suggesting the need for further clinical investigation with a focus on circadian biology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Isabelle A. Van der Linden, Esther M. Hazelhoff, Eline R. De Groot, Daniel C. Vijlbrief, Luc J. M. Schlangen, Yvonne A. W. De Kort, Marijn J. Vermeulen, Demy Van Gilst, Jeroen Dudink, Laura Kervezee
Summary: This study characterized the 24-h light exposure patterns in the Neonatal Intensive Care Unit (NICU) and explored the factors influencing these patterns. It was found that the NICU followed a 24-h light-dark cycle, with significant differences in light exposure between nurse shifts. Light exposure was generally low and varied between patients. Birth season and phototherapy had a significant impact on the light-dark cycle, while bed location and illness severity did not.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biology
Benjamin Coiffard, Aissatou Bailo Diallo, Soraya Mezouar, Marc Leone, Jean-Louis Mege
Summary: In mammals, including humans, the body temperature displays a strict circadian rhythm and has to be maintained within a narrow range to allow optimal physiological functions. There is growing evidence on the role of temperature circadian rhythm on the expression of the molecular clock. The disruption of body temperature, such as fever, is associated with diseases and may reflect a process to activate the molecular clock and trigger immune responses. Monitoring body temperature can predict outcomes and guide future studies in chronotherapy.
Article
Biology
Ana Paula Francisco, Andre Comiran Tonon, Guilherme Rodriguez Amando, Maria Paz Hidalgo
Summary: The objective of this study was to evaluate the relationship between self-perceived rhythms and depressive and psychiatric symptoms. The study found that lower self-perceived rhythmicity in cognitive factors and higher self-perceived rhythmicity in affective factors were related to presence and intensity of psychiatric and depressive symptoms.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Physiology
Antonino Mule, Eleonora Bruno, Patrizia Pasanisi, Letizia Galasso, Lucia Castelli, Andrea Caumo, Fabio Esposito, Eliana Roveda, Angela Montaruli
Summary: This study compares the circadian rhythm characteristics of males and females with Metabolic Syndrome, showing that females exhibit higher daily activity levels in certain parameters of circadian rhythm.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Laura Kervezee, Fernando Gonzales-Aste, Phillipe Boudreau, Diane B. Boivin
Summary: This study examined the impact of chronotype on sleep behavior in police officers working rotating shifts. It found that individuals with a morning chronotype tended to have longer sleep duration during morning shifts, while evening chronotypes had longer sleep duration during evening shifts. Moreover, evening chronotypes showed longer main sleep episode duration during night shifts, but this was affected by increased napping in morning chronotypes during the same shifts.
Article
Biology
Andre Comiran Tonon, Luisa K. Pilz, Guilherme Rodriguez Amando, Debora Barroggi Constantino, Rogerio Boff Borges, Arthur Caye, Fernanda Rohrsetzer, Laila Souza, Helen L. Fisher, Brandon A. Kohrt, Valeria Mondelli, Christian Kieling, Marco Idiart, Antoni Diez-Noguera, Maria Paz Hidalgo
Summary: This study presents a handling procedure for off-wrist episodes in actimetry time series of motor activity. The results show that replacing missing values with zeroes increases variance, and it is recommended to use NA instead.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Lisa Goncalves, Duarte Goncalves, Teresa Esteban-Casanelles, Tiago Barroso, Ines Soares de Pinho, Raquel Lopes-Bras, Miguel Esperanca-Martins, Vanessa Patel, Sofia Torres, Rita Teixeira de Sousa, Andre Mansinho, Luis Costa
Summary: Although the impact of circadian timing on immunotherapy has not been implemented in clinical practice yet, chronoimmunotherapy shows potential as circadian oscillations are observed in immune cell numbers and the expression of immunotherapy targets. Retrospective studies suggest that morning infusions may lead to higher effectiveness of immune checkpoint inhibitors in melanoma, non-small cell lung cancer, and kidney cancer.
Article
Nutrition & Dietetics
Luis Baquerizo-Sedano, Jose A. Chaquila, Luis Aguilar, Jose M. Ordovas, Pedro Gonzalez-Muniesa, Marta Garaulet
Summary: The study found that long-term confinement has impacts on sunlight exposure, sleep duration, sedentary time, and meal times among university students, and is associated with a doubled obesity rates.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Marta Garaulet, Jesus Lopez-Minguez, Hassan S. Dashti, Celine Vetter, Antonio Miguel Hernandez-Martinez, Millan Perez-Ayala, Juan Carlos Baraza, Wei Wang, Jose C. Florez, Frank A. J. L. Scheer, Richa Saxena
Summary: This study revealed that late eating combined with high levels of melatonin and carbohydrate intake impairs glucose tolerance, especially in carriers of the MTNR1B G-risk allele, due to defects in insulin secretion.
Article
Biochemistry & Molecular Biology
Sarah L. Chellappa, Phillip A. Engen, Ankur Naqib, Jingyi Qian, Nina Vujovic, Nishath Rahman, Stefan J. Green, Marta Garaulet, Ali Keshavarzian, Frank A. J. L. Scheer
Summary: This study found that human oral microbiota has endogenous circadian rhythms and that circadian misalignment significantly affects the composition and functional pathways of the microbiota, particularly those related to metabolism and immune function. These findings have translational relevance for individuals exposed to circadian misalignment, such as night shift workers and frequent travelers.
Article
Medical Laboratory Technology
Juan Luis Romero-Cabrera, Marta Garaulet, Jose Jimenez-Torres, Juan F. Alcala-Diaz, Gracia M. Quintana Navarro, Laura Martin-Piedra, Jose David Torres-Pena, Fernando Rodriguez-Cantalejo, Oriol Alberto Rangel-Zuniga, Elena Maria Yubero-Serrano, Raul M. Luque, Jose M. Ordovas, Jose Lopez-Miranda, Pablo Perez-Martinez, Antonio Garcia-Rios
Summary: Individuals with evening chronotypes have higher cardiometabolic risk and less robust circadian-related rhythms compared to morning-types, regardless of the nutritional intervention.
TRANSLATIONAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Siena C. Gioia, Melanie Guirette, Angela Chen, Chandler Tucker, Brianna E. Gray, Celine Vetter, Marta Garaulet, Frank A. J. L. Scheer, Richa Saxena, Hassan S. Dashti
Summary: There are currently no standard and low-cost methods to assess the timing of food intake. However, this study has validated simple, recall-based questions that can effectively characterize food timing in free-living populations.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)
Letter
Nutrition & Dietetics
Luis Baquerizo-Sedano, J. A. Chaquila, Luis Aguilar, J. M. Ordovas, Pedro Gonzalez-Muniesa, Marta Garaulet
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Alejandra Betancourt-Nunez, Nathaly Torres-Castillo, Erika Martinez-Lopez, Cesar O. De Loera-Rodriguez, Elvira Duran-Barajas, Fabiola Marquez-Sandoval, Maria Fernanda Bernal-Orozco, Marta Garaulet, Barbara Vizmanos
Summary: Emotional eating is associated with unhealthy dietary patterns in individuals with abdominal obesity.
Article
Endocrinology & Metabolism
Andrew W. McHill, Lindsey S. Brown, Andrew J. K. Phillips, Laura K. Barger, Marta Garaulet, Frank A. J. L. Scheer, Elizabeth B. Klerman
Summary: This study examined the relationship between the timing of energy intake and body composition based on mathematically modeled circadian timing and in-laboratory collected metrics. The findings suggest that the use of mathematically modeled circadian timing can provide similar results to in-laboratory measurements, which may be beneficial in time-based interventions.
Article
Multidisciplinary Sciences
Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nistico, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordonana, Juan F. Sanchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret Boomsma, Thorkild I. A. Sorensen, Tellervo Korhonen, Jaakko Kaprio
Summary: This study tested the causality between education and smoking using discordant twin pairs. The results support the hypothesis that education has a causal effect on current smoking status and smoking cessation. Furthermore, genetic factors also contribute to these associations, as seen in the greater differences within dizygotic twin pairs who share only 50% of their segregating genes.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Juan J. Madrid-Valero, Juan F. Sanchez-Romera, Jose M. Martinez-Selva, Juan R. Ordonana
Summary: The genetic and environmental underpinnings of sleep quality have been extensively studied, but there is limited knowledge about the etiology and associations of different sleep quality dimensions. This study aimed to investigate the structure of sleep quality dimensions using a population-based twin sample. The findings suggest significant genetic overlap among most components of sleep quality, but there is also considerable specificity in the genetic-environmental structure of these dimensions.
Article
Cell Biology
Nina Vujovic, Matthew J. Piron, Jingyi Qian, Sarah L. Chellappa, Arlet Nedeltcheva, David Barr, Su Wei Heng, Kayla Kerlin, Suhina Srivastav, Wei Wang, Brent Shoji, Marta Garaulet, Matthew J. Brady, Frank A. J. L. Scheer
Summary: Late eating is associated with increased risk of obesity, possibly due to increased hunger, altered appetite-regulating hormones, disrupted energy balance, and enhanced adipogenesis.
Article
Clinical Neurology
Juan J. Madrid-Valero, Robert M. Kirkpatrick, Francisca Gonzalez-Javier, Alice M. Gregory, Juan R. Ordonana
Summary: There is a moderate genetic association between poor sleep quality and psychological distress, accounting for 44% of the association between these two variables. Significant genetic and non-shared environmental correlations were found, indicating a moderate overlap between genetic and environmental factors influencing both phenotypes. Sex did not significantly influence the genetic and environmental influences on these variables.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Endocrinology & Metabolism
Marta Garaulet, Barbara Vizmanos, Teresa Muela, Alejandra Betancourt-Nunez, Maria-angeles Bonmati-Carrion, Celine Vetter, Hassan S. Dashti, Richa Saxena, Frank A. J. L. Scheer
Summary: This study aimed to investigate the relationship between being an evening type and reporting emotional eating behaviors. The results showed that evening types had higher scores on emotional eating and were more likely to be emotional eaters. They also scored higher on disinhibition/overeating and food craving factors. A meta-analysis revealed that being an evening type was associated with a higher score on emotional eating. Furthermore, individuals with late dim-light melatonin onset showed higher scores on emotional eating.
Article
Endocrinology & Metabolism
Barbara Vizmanos, Ana Isabel Cascales, Maria Rodriguez-Martin, Diego Salmeron, Eva Morales, Aurora Aragon-Alonso, Frank A. J. L. Scheer, Marta Garaulet
Summary: This study aimed to investigate the association between siestas and obesity, considering siesta duration and whether siesta traits and/or lifestyle factors mediate this association. The results showed that long siestas were associated with higher BMI, waist circumference, fasting glucose, blood pressure, and increased prevalence of MetS. However, short siestas were associated with a lower probability of elevated blood pressure. Various factors, including smoking, sleep and eating schedules, energy intake, and siesta location, mediated the association of siestas with obesity and MetS.
Article
Anesthesiology
Lucas Calais-Ferreira, Daniel Pozzobon, Marina B. Pinheiro, Fiona M. Blyth, Juan R. Ordonana, Glen E. Duncan, John L. Hopper, Paulo H. Ferreira, Manuela L. Ferreira
Summary: This study investigates sex differences in low back pain among opposite-sex twin pairs, taking into account familial factors.
EUROPEAN JOURNAL OF PAIN
(2023)