Review
Cell Biology
Deepak Kumar, Ashish Sharma, Rajeev Taliyan, Maiko T. Urmera, Oscar Herrera-Calderon, Thomas Heinbockel, Shafiqur Rahman, Rohit Goyal
Summary: Circadian rhythms are regulated by the master clock in the suprachiasmatic nucleus, entrained to the light-dark cycle by the retino-hypothalamic tract. Disruption of circadian rhythms due to unhealthy lifestyle and chronic photic disturbances has been linked to Alzheimer's disease. The presence of endocannabinoids in CRd-induced Alzheimer's disease has been identified as a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Review
Neurosciences
Kari R. Hoyt, Karl Obrietan
Summary: The circadian timing system modulates basic processes in mammals, including the central nervous system. Recent studies have shown that the clock timing system influences complex behavioral states such as learning, memory, and mood. The clock affects cellular signaling events, gene networks, and synaptic circuits, shaping cognitive capacity over the circadian cycle. Dysregulation of circadian timing, particularly in cortical and limbic circuits, is associated with cognitive impairments in Alzheimer's disease (AD). Disruption of timing could accelerate AD pathogenesis, leading to a further disruption of the circadian timing system. Potential therapeutic approaches to strengthen cellular timing networks may improve cognitive capacity in AD patients.
MOLECULAR NEURODEGENERATION
(2022)
Article
Geriatrics & Gerontology
Fabian-Xose Fernandez, Sevag Kaladchibachi, David C. Negelspach
Summary: Many believe circadian impairments in aging and Alzheimer's disease are due to tissue degeneration in the central pacemaker, the SCN. However, studies have shown limited atrophy in the SCNs of older individuals and Alzheimer's patients, suggesting the SCN is resilient and not solely responsible for circadian disorganization. Future research directions are proposed to bridge this conceptual gap and improve health outcomes in later adulthood.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Deborah A. M. Joye, Kayla E. Rohr, Kimberlee Suenkens, Alissa Wuorinen, Thomas Inda, Madeline Arzbecker, Emma Mueller, Alec Huber, Harshida Pancholi, Murray G. Blackmore, Vania Carmona-Alcocer, Jennifer A. Evans
Summary: Daily and annual changes in light are processed by central clock circuits. The role of somatostatin (SST) in the response of the suprachiasmatic nucleus (SCN) to light has not been examined. Our study shows that SST signaling regulates daily rhythms in behavior and SCN function, with sex-specific effects. Lack of SST signaling increases circadian plasticity and eliminates sex differences in photic responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Si Li, Ziqi Tian, Xiaohui Xian, Cuihuan Yan, Qiang Li, Nan Li, Xiaokang Xu, Xiaojie Hou, Xiaoyun Zhang, Yinan Yang, Sisi Xue, Shengkai Ma, Shuanlong Cui, Lijun Sun, Xiaoguang Yao
Summary: The study aimed to investigate the effects of catalpol on anti-amyloid beta (Aβ) and anti-neuroinflammatory effects in an Alzheimer's disease (AD) mouse model. Catalpol inhibited Aβ formation, reduced proinflammatory cytokines and cytotoxicity, downregulated neuroinflammation production, decreased Aβ deposits, and alleviated cognitive impairment. The administration of catalpol may be a promising strategy for treating AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Tomas Jorda-Siquier, Melina Petrel, Vladimir Kouskoff, Una Smailovic, Fabrice Cordelieres, Susanne Frykman, Ulrike Mueller, Christophe Mulle, Gael Barthet
Summary: The distribution of amyloid precursor protein (APP) and its fragments is altered in Alzheimer's disease (AD), leading to their accumulation around amyloid plaques with presynaptic proteins. This finding is associated with histopathological features and familial AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Arthur H. Cheng, Samuel W. Fung, Sara Hegazi, Osama Hasan Mustafa Hasan Abdalla, Hai-Ying Mary Cheng
Summary: The hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, and the transcription factor Sox2 plays a crucial role in controlling the expression of circadian neuropeptides and transcription factors in the embryonic SCN. Sox2 deficiency leads to reduced survival of SCN neurons during the postnatal period, but does not affect progenitor cell proliferation or SCN specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Summary: This study reveals the role of a clock-output molecule in reducing arousal circuit excitability during the active phase, suggesting a multifaceted role for the circadian clock in regulating arousal.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Wangchen Tsering, Stefan Prokop
Summary: This article reviews the research on neuritic plaques and discusses their association with AD progression and symptoms. Neuritic plaques are linked to local immune activation, neuronal network dysfunction, and cognitive decline, highlighting the importance of understanding their formation mechanism for developing targeted therapies for AD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Hester C. van Diepen, Robin A. Schoonderwoerd, Ashna Ramkisoensing, Jan A. M. Janse, Samer Hattar, Johanna H. Meijer
Summary: The study reveals the significant role of cone photoreceptors in regulating circadian rhythms, transmitting light information to the suprachiasmatic nuclei, and affecting their electrical activity levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Eunbi Cho, Kumju Youn, Huiyoung Kwon, Jieun Jeon, Wan-Seob Cho, Se Jin Park, Seung Hwan Son, Dae Sik Jang, Chan Young Shin, Minho Moon, Mira Jun, Nam-Jung Kim, Dong Hyun Kim
Summary: This study investigated the effects of eugenitol in an AD mouse model and found that it inhibits the formation of A beta plaques and reduces neuronal cell death. In silico docking simulation showed that eugenitol may interact with A beta monomers and fibrils.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Obstetrics & Gynecology
Aurelija Dubicke, Gunvor Ekman-Ordeberg, Patricia Mazurek, Lindsay Miller, Steven M. Yellon
REPRODUCTIVE SCIENCES
(2016)
Review
Reproductive Biology
Steven M. Yellon
BIOLOGY OF REPRODUCTION
(2017)
Article
Obstetrics & Gynecology
Michael A. Kirby, Anne C. Heuerman, Melisa Custer, Abigail E. Dobyns, Ryan Strilaeff, Kathleen N. Stutz, Jaclyn Cooperrider, Joseph G. Elsissy, Steven M. Yellon
REPRODUCTIVE SCIENCES
(2016)
Article
Endocrinology & Metabolism
Natasha Singh, Bronwen Herbert, Gavin R. Sooranna, Nicolas M. Orsi, Lydia Edey, Tathagata Dasgupta, Suren R. Sooranna, Steven M. Yellon, Mark R. Johnson
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Pediatrics
Allison Judkins, Rhaya L. Johnson, Samuel T. Murray, Steven M. Yellon, Christopher G. Wilson
PEDIATRIC RESEARCH
(2018)
Meeting Abstract
Obstetrics & Gynecology
Christopher Nold, Monique Maubert, Lauren Anton, Michal Elovitz
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Article
Multidisciplinary Sciences
Steven M. Yellon, Abigail E. Dobyns, Hailey L. Beck, James T. Kurtzman, Robert E. Garfield, Michael A. Kirby
Article
Multidisciplinary Sciences
Abigail E. Dobyns, Ravi Goyal, Lauren Grisham Carpenter, Tom C. Freeman, Lawrence D. Longo, Steven M. Yellon
Article
Reproductive Biology
S. M. Yellon, E. Greaves, A. C. Heuerman, A. E. Dobyns, J. E. Norman
BIOLOGY OF REPRODUCTION
(2019)
Article
Obstetrics & Gynecology
Anne C. Heuerman, Trevor T. Hollinger, Ramkumar Menon, Sam Mesiano, Steven M. Yellon
REPRODUCTIVE SCIENCES
(2019)
Article
Obstetrics & Gynecology
Christopher Nold, Julie Stone, Kathleen O'Hara, Patricia Davis, Vladislav Kiveliyk, Vanessa Blanchard, Steven M. Yellon, Anthony T. Vella
REPRODUCTIVE SCIENCES
(2019)
Article
Multidisciplinary Sciences
Samantha Sheller-Miller, Jayshil Trivedi, Steven M. Yellon, Ramkumar Menon
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Christopher Nold, Todd Jensen, Kathleen O'Hara, Julie Stone, Steven M. Yellon, Anthony T. Vella
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Reproductive Biology
Natasha Singh, Bronwen Herbert, Gavin Sooranna, Anya Das, Suren R. Sooranna, Steven M. Yellon, Mark R. Johnson
BIOLOGY OF REPRODUCTION
(2019)
Article
Neurosciences
George T. Mukosera, Tatianna C. Clark, Larry Ngo, Taiming Liu, Hobe Schroeder, Gordon G. Power, Steven M. Yellon, Mana M. Parast, Arlin B. Blood
JOURNAL OF PHYSIOLOGY-LONDON
(2020)