期刊
CHROMOSOME RESEARCH
卷 20, 期 8, 页码 1009-1015出版社
SPRINGER
DOI: 10.1007/s10577-012-9306-z
关键词
RNA polymerase II; CELF1; oocyte; localization microscopy
资金
- Heidelberg University
- Deutsche Forschungsgemeinschaft (DFG)
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM33397]
We have examined transcription loops on lampbrush chromosomes of the newt Notophthalmus by superresolution microscopy. Because of the favorable, essentially two-dimensional morphology of these loops, an average optical resolution in the x-y plane of about 50 nm was achieved. We analyzed the distribution of the multifunctional RNA-binding protein CELF1 on specific loops. CELF1 distribution is consistent with a model in which individual transcripts are tightly folded and hence closely packed against the loop axis.
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