期刊
CHROMOSOMA
卷 123, 期 3, 页码 169-181出版社
SPRINGER
DOI: 10.1007/s00412-013-0446-5
关键词
KNL1; Kinetochore; Mitosis; SAC activation; SAC silencing; Chromosome congression
资金
- National Institutes of Health (NIH) [R01GM088371]
KNL1 is an evolutionarily conserved kinetochore-associated protein essential for accurate chromosome segregation in eukaryotic cells. This large scaffold protein, predicted to be almost entirely unstructured, is involved in diverse mitotic processes including kinetochore assembly, chromosome congression, and mitotic checkpoint signaling. How this kinetochore hub coordinates protein-protein interactions spatially and temporally during mitosis to orchestrate these processes is an area of active investigation. Here we summarize the current understanding of KNL1 and discuss possible mechanisms by which this protein actively contributes to multiple aspects of mitotic progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据