期刊
CHROMOSOMA
卷 121, 期 6, 页码 539-554出版社
SPRINGER
DOI: 10.1007/s00412-012-0388-3
关键词
Nuclear envelope formation; Nuclear pore complex assembly; Chromatin decondensation; Mitotic exit
The metazoan nucleus is disassembled and re-built at every mitotic cell division. The nuclear envelope, including nuclear pore complexes, breaks down at the beginning of mitosis to accommodate the capture of massively condensed chromosomes by the spindle apparatus. At the end of mitosis, a nuclear envelope is newly formed around each set of segregating and de-condensing chromatin. We review the current understanding of the membrane restructuring events involved in the formation of the nuclear membrane sheets of the envelope, the mechanisms governing nuclear pore complex assembly and integration in the nascent nuclear membranes, and the regulated coordination of these events with chromatin de-condensation.
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