期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 12, 页码 1914-1922出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiv597
关键词
Enterococcus faecium; clades; GIT; colonization; fitness
资金
- National Institutes of Health from the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases [R21 AI103260-01]
Colonization of the gastrointestinal tract (GIT) generally precedes infection with antibiotic-resistant Enterococcus faecium. We used a mouse GIT colonization model to test differences in the colonization levels by strains from different E. faecium lineages: clade B, part of the healthy human microbiota; subclade A1, associated with infections; and subclade A2, primarily associated with animals. After mono-inoculation, there was no significant difference in colonization (measured as the geometric mean number of colony-forming units per gram) by the E. faecium clades at any time point (P > .05). However, in competition assays, with 6 of the 7 pairs, clade B strains outcompeted clade A strains in their ability to persist in the GIT; this difference was significant in some pairs by day 2 and in all pairs by day 14 (P < .0008-.0283). This observation may explain the predominance of clade B in the community and why antibiotic-resistant hospital-associated E. faecium are often replaced by clade B strains once patients leave the hospital.
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