Article
Biophysics
Rui Li, Cong Feng, Runqian Yang, Xiangfeng Li, Liping Ruan
Summary: In this study, a new drug delivery system based on a filter-like blocking system using MSN with small gatekeeper was developed. The system demonstrated controlled drug release with stimuli responsiveness, significant inhibition of cancer cells, and good biocompatibility with normal cells. This novel system provides a potential synergistic molecule for cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Yi-Fan Gao, Rui Zou, Guang-Feng Chen, Bo-Mei Liu, Yong Zhang, Ju Jiao, Ka-Leung Wong, Jing Wang
Summary: The study introduces a tailorable large-pore mesoporous-silica-assisted synthesis strategy to synthesize a series of ZnGa2O4:Cr3+/Sn4+@MSNs (ZGOCS@MSNs) near infrared persistent luminescence nanospheres as a nanoplatform. The performance of ZGOCS@MSNs increases with the mass ratio of ZGOCS to MSNs (MRZM), indicating the crucial role of MRZM in optimizing the NIR-PersL performance of the nanospheres. The employment of large pore MSNs not only enhances NIR-PersL performance but also maintains sufficient residual pore volume for efficient drug loading/releasing, leading to high dose loading of DOX and outstanding cancer cell killing efficiency.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Parya Kazemzadeh, Khalil Sayadi, Ali Toolabi, Jalil Sayadi, Malihe Zeraati, Narendra Pal Singh Chauhan, Ghasem Sargazi
Summary: Mesoporous silica nanoparticles (MSNs) are widely used in drug delivery applications due to their favorable biocompatibility and controlled drug release properties. However, more research, such as in vivo biocompatibility studies and toxicity studies, is needed to advance this field.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Albert Yu, Xiaoyong Dai, Zixian Wang, Huaqing Chen, Bing Guo, Laiqiang Huang
Summary: Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Article
Pharmacology & Pharmacy
Siti Norain Harun, Haslina Ahmad, Hong Ngee Lim, Suet Lin Chia, Martin R. Gill
Summary: Ru-PIP is a potential anticancer drug that acts by inhibiting DNA replication, and its limited bioavailability can be overcome by using mesoporous silica nanoparticles (MSNs) as a drug delivery agent. Encapsulated Ru-PIP in MSNs exerted significant cytotoxicity on cancer cell lines, indicating the potential of MSNs as an ideal drug delivery agent for sustained release of Ru-PIP by diffusion.
Article
Engineering, Mechanical
Li Wan, Yi Wang, Xiaolong Tan, Yulong Sun, Jing Luo, Hongyu Zhang
Summary: This study developed biodegradable lubricating drug-loaded nanoparticles for the treatment of osteoarthritis. The nanoparticles showed enhanced lubrication and sustained drug release behavior. The results suggest that these nanoparticles may be a promising approach for osteoarthritis therapy.
Article
Chemistry, Physical
Cristina Carucci, Giulia Sechi, Marco Piludu, Maura Monduzzi, Andrea Salis
Summary: This study focuses on optimizing the loading and release processes of the flavonoid quercetin by changing the solvent composition, leading to a more sustained release and improved stability and release concentration of quercetin in a pH-sensitive antimicrobial drug delivery system based on Mesoporous silica nanoparticles (MSN) functionalized with different compounds.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Diogo Marinheiro, Barbara J. M. L. Ferreira, Parastu Oskoei, Helena Oliveira, Ana L. Daniel-da-Silva
Summary: The study evaluated the potential of RES-loaded mesoporous silica nanoparticles for melanoma treatment, demonstrating their potential in promoting RES release. In vitro experiments showed that RES-loaded nanoparticles exhibited cytotoxicity against melanotic cell lines, with a stronger effect on amelanotic cells.
Article
Biophysics
Jinhua Liu, Guotong Ruan, Wenlin Ma, Yujie Sun, Haidong Yu, Zhihui Xu, Changmin Yu, Hai Li, Cheng-wu Zhang, Lin Li
Summary: A direct in situ high-performance HRP-labeled fluorescent immunoassay platform was developed using a rapid in situ fluorogenic reaction between PEI and PPD analogues to generate FCNPs. The proposed method exhibited a wide dynamic range and low detection limit, and was successfully applied to evaluate cTnI and SARS-CoV-2 N protein levels in serum.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biochemistry & Molecular Biology
Congcong Zhang, Yufei Xue, Lan Wang, Qiong Wu, Bin Fang, Yu Sheng, Hua Bai, Bo Peng, Naidi Yang, Lin Li
Summary: Mitochondrial DNA (mtDNA) is the genetic information of mitochondrion and mutations can lead to mitochondrial diseases affecting organs highly dependent on aerobic metabolism. Accurate diagnosis and treatment rely on detecting mtDNA and developing drugs targeting it. Progress has been made in developing probes and drugs for mtDNA-related disorders, advancing fundamental research in mitochondrial diseases.
Review
Chemistry, Multidisciplinary
Wenhui Ji, Xiao Tang, Wei Du, Yao Lu, Nanxiang Wang, Qiong Wu, Wei Wei, Jie Liu, Haidong Yu, Bo Ma, Lin Li, Wei Huang
Summary: Mitochondria play a crucial role in providing energy for cellular activities and disruptions in mitochondrial energy metabolism can lead to various diseases. Developing accurate methods for detecting mitochondrial energy metabolites is of great importance in understanding and treating these conditions.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Bin Fang, Beilin Zhang, Rongxiu Zhai, Limin Wang, Yang Ding, Huizi Li, Hua Bai, Zhenhua Wang, Bo Peng, Lin Li, Li Fu
Summary: The development of three novel water-soluble TP active sulfosalt derivatives in this study showed high sensitivity to mitochondrial viscosity, with significant changes as the environmental viscosity increased. Among them, Mito-Q was sensitive to local viscosity and selectively stained mitochondria.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Xingwei Chen, Zhongxi Huang, Lihua Huang, Qian Shen, Nai-Di Yang, Chibin Pu, Jinjun Shao, Lin Li, Changmin Yu, Wei Huang
Summary: Fluorescent probes have been extensively studied and applied in environment and health analysis. Covalent assembly probes, as a novel type of reaction probes, have many advantages. Significant contributions have been made in both the application and mechanism of covalent assembly probes over the past decade. This review summarizes the recent development of covalent assembly probes, classifies them based on different analytes, and introduces their detection mechanism in detail.
Review
Multidisciplinary Sciences
Jintao Li, Jie Chen, Hua Bai, Haiwei Wang, Shiping Hao, Yang Ding, Bo Peng, Jing Zhang, Lin Li, Wei Huang
Summary: Microfluidic-based organs-on-chips (OoCs) are an advanced technology in biomedical and chemical research, offering unique properties for biomedical applications. However, the amount of data generated by OoC systems has surpassed manual analysis capabilities. Deep learning, a new area in machine learning, can automatically analyze big data and has successful applications in various fields. The integration of deep learning in OoCs shows great potential for drug development, disease modeling, and personalized medicine.
Article
Engineering, Biomedical
Cao Cui, Chenlu Wang, Qinrui Fu, Jibin Song, Jianhua Zou, Ling Li, Jianwei Zhu, Wei Huang, Lin Li, Zhen Yang, Xiaoyuan Chen
Summary: This study developed a generic self-assembly approach to design nano-phototheranostics with NIR-II fluorescence imaging and phototherapy. The morphology of the resulting nanoparticles can be controlled by adjusting the ratio of the components. The nanoparticles exhibit bright fluorescence and effective photothermal and photodynamic properties, showing great potential for cancer phototheranostics.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Jia Zhou, Wei Du, Tao Shao, Zheng Li, Duoteng Zhang, Lan Wang, Zhijie Fang, Jie Li, Qiong Wu, Chengwu Zhang, Lin Li
Summary: Impaired mitophagy prevents damaged mitochondria clearance and leads to pathological states. Understanding this phenomenon is crucial for disease diagnosis and pathogenesis understanding. A mitochondrial-targeting fluorescence probe, Z2, was developed in this study for pH variation evaluation, showing remarkable detection ability in biological applications.
Review
Chemistry, Multidisciplinary
Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Naidi Yang, Gongqiang Li, Qiong Wu, Wei Wang, Lin Li, Changmin Yu
Summary: This article provides an overview of the application of mitochondria-targeted nanocarriers in function regulation and discusses the advantages and disadvantages of different strategies for nanocarrier targeting of mitochondria. The article also explores the future prospects of mitochondria-targeted delivery systems in drug-based therapeutics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biophysics
Wanxia Wu, Lan Wang, Ya Yang, Wei Du, Wenhui Ji, Zhijie Fang, Xiyan Hou, Qiong Wu, Chengwu Zhang, Lin Li
Summary: Optical flexible biosensors offer greater flexibility in detecting analytes, providing real-time and non-invasive monitoring of physical conditions or metabolites. They are gaining increasing attention for their potential in medical diagnosis and health detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Wei Du, Jiqing Wang, Haixiao Fang, Wenhui Ji, Yi Liu, Yunwei Qu, Duoteng Zhang, Tao Shao, Xiyan Hou, Qiong Wu, Lin Li
Summary: A dual-functional fluorescent probe, CQ-1, was designed for rapid and accurate detection of early cancer biomarkers. It can visualize the changes of nitroreductase and viscosity in cancer cell mitochondria while displaying mitochondrial targeting ability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Oxidative stress is believed to be the main cause of PD, and antioxidants have shown potential for its treatment. The study investigated the effects of vitamin B12 (VB12) supplementation in cellular and animal models of PD, and found that VB12 reduced reactive oxygen species (ROS) generation, improved motor dysfunction, and protected against mitochondrial dysfunction and dopaminergic neuron loss. These findings suggest that vitamin supplementation may be a safer and more feasible approach for PD intervention compared to chemical drug treatment.
Article
Chemistry, Analytical
Ya Yang, Wenhui Ji, Yutao Yin, Nanxiang Wang, Wanxia Wu, Wei Zhang, Siying Pei, Tianwei Liu, Chao Tao, Bing Zheng, Qiong Wu, Lin Li
Summary: Rapid and accurate detection of glucose and hydrogen peroxide concentrations is crucial for predictive diagnosis of diseases. A porous two-dimensional conductive metal-organic framework (cMOF), Ni-HHTP, was used to construct enzyme-free paper-based electrochemical sensors. These sensors demonstrated low limits of detection (1.30 μM for Glu and 2.13 μM for H2O2) and high sensitivities (5573.21 μA/μM·cm-2 for Glu and 179.85 μA/μM·cm-2 for H2O2). Notably, the Ni-HHTP-based sensors successfully analyzed real biological samples, distinguishing human serum from artificial sweat samples. This study highlights the potential of cMOFs in the design and development of multifunctional and high-performance flexible electronic sensors.
Article
Pharmacology & Pharmacy
Chenqi Xin, Naidi Yang, Yaqi Ding, Linqi Han, Zhiqiang Zhou, Xiaolu Guo, Zhijie Fang, Hua Bai, Bo Peng, Chengwu Zhang, Lin Li
Summary: Vitamin B-3 and its derivative Mito-VB3 have been found to protect against Parkinson's disease and other mitochondrial dysfunction-related diseases by restoring mitochondrial function, demonstrating remarkable neuroprotective effects.
ADVANCED THERAPEUTICS
(2022)
Review
Biochemical Research Methods
Bo Peng, Shiping Hao, Ziqiu Tong, Hua Bai, Sijun Pan, Kah-Leong Lim, Lin Li, Nicolas H. Voelcker, Wei Huang
Summary: The blood-brain barrier (BBB) chip technology is a highly promising in vitro platform that mimics the human BBB microenvironments. In addition to its wide application in brain cancer research, it also holds great potential in other brain disease models.