A New Enantioselective Synthesis of the Anticonvulsant Drug Pregabalin (Lyrica) Based on a Hydrolytic Kinetic Resolution Method

Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases

(2013) Christoph K. Winkler et al.   JOURNAL OF ORGANIC CHEMISTRY

Enzymatic production of (S)-3-cyano-5-methylhexanoic acid ethyl ester with high substrate loading by immobilized Pseudomonas cepacia lipase

(2012) Ren-Chao Zheng et al.   TETRAHEDRON-ASYMMETRY

An alternate synthesis of enantiomerically pure levetiracetam (Keppra®)

(2012) M. Mujahid et al.   TETRAHEDRON-ASYMMETRY

First asymmetric synthesis of the antiepileptic drug Lacosamide (Vimpat®) based on a hydrolytic kinetic resolution strategy

(2011) M. Muthukrishnan et al.   TETRAHEDRON-ASYMMETRY

A Role of GABA Analogues in the Treatment of Neurological Diseases

(2010) K. Gajcy et al.   CURRENT MEDICINAL CHEMISTRY

Solvent-free organocatalytic Michael addition of diethyl malonate to nitroalkenes: the practical synthesis of Pregabalin and γ-nitrobutyric acid derivatives

(2010) Jin-ming Liu et al.   TETRAHEDRON

A convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method

(2010) Murugesan Sasikumar et al.   TETRAHEDRON-ASYMMETRY

A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method

(2010) Milind D. Nikalje et al.   TETRAHEDRON-ASYMMETRY

A Simple Organocatalytic Enantioselective Synthesis of Pregabalin

(2009) Oriol Bassas et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An Efficient Process of Racemization of 3-(Carbamoylmethyl)-5-methylhexanoic acid: A Pregabalin Intermediate

(2009) Anil B. Chavan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Chemoenzymatic Manufacturing Process for Pregabalin

(2008) Carlos A. Martinez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Stereoselective and efficient synthesis of (S)-pregabalin from d-mannitol

(2008) Sandra Izquierdo et al.   TETRAHEDRON-ASYMMETRY

A facile chemoenzymatic approach to chiral non-racemic β-alkyl-γ-amino acids and 2-alkylsuccinic acids. A concise synthesis of (S)-(+)-Pregabalin

(2008) Fulvia Felluga et al.   TETRAHEDRON-ASYMMETRY