期刊
CHIRALITY
卷 26, 期 2, 页码 79-87出版社
WILEY
DOI: 10.1002/chir.22266
关键词
enantioselective liquid-liquid extraction; BINAP; metal complex; enantiomers; model
资金
- National Science Foundation of China [21171054]
- Open Fund Project of Key Laboratory in Hunan University [11K029]
- Key Laboratory of Hunan Province
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
BINAP-metal complexes were prepared as extractant for enantioselective liquid-liquid extraction (ELLE) of amino-(4-nitro-phenyl)-acetic acid (NPA) enantiomers. The influence of process variables, including types of organic solvents and metal precursor, concentration of ligand, pH, and temperature on the efficiency of the extraction, were investigated experimentally. An interfacial reaction model was established for insightful understanding of the chiral extraction process. Important parameters required for the model were determined. The experimental data were compared with model predictions to verify the model prediction, It was found that the interfacial reaction model predicted the experimental results accurately. By modeling and experiment, an optimal extraction condition with pH of 7 and host (extractant) concentration of 1mmol/L was obtained and high enantioselectivity ((op)) of 3.86 and performance factor (pf) of 0.1949 were achieved. Chirality 26:79-87, 2014. (c) 2013 Wiley Periodicals, Inc.
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