期刊
CHIRALITY
卷 26, 期 1, 页码 56-60出版社
WILEY
DOI: 10.1002/chir.22267
关键词
asymmetric hydrogenation; phosphites; quinaldine hydrochloride; pirlindole
资金
- Ministry of Science and Education [8435, 8531]
A series of chiral phosphite-type ligands was tested in asymmetric Ir-catalyzed hydrogenation of quinolines and 2,4,5,6-tetrahydro-1H-pyrazino(3,2,1-j,k)carbazole. Hydrogenation of quinaldine hydrochloride provided superior enantioselectivity up to 65% ee compared to quinaldine free base. The ligands were tested for the first time in the asymmetric Ir-Ircatalyzed hydrogenation of 2,4,5,6-tetrahydro-1H-pyrazino(3,2,1-j,k)carbazole yielding the antidepressant drug, pirlindole. Chirality 26:56-60, 2013. (c) 2013 Wiley Periodicals, Inc.
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