期刊
CHIRALITY
卷 24, 期 3, 页码 255-261出版社
WILEY-BLACKWELL
DOI: 10.1002/chir.21994
关键词
asymmetric catalysis; diethylzinc reaction; dual stereoselection; ketopinic acid; hydroxyamides
The screening of the catalytic activity in the diethylzinc reaction of a series of easily accessible (1S)-ketopinic-acid derived hydroxyamides, designed by key structure modifications of a parent highly active related bis(hydroxyamide), has allowed to find the first case of dual stereoselection in highly structurally close ligands of such interesting chemically sustainable typology. The found striking dual stereoselection is explained on the basis of empiric models for the acting zinc catalysts and involved controlling transition states, which are supported by additional specific experimental structure-activity tests. Chirality, 2012. (C) 2012 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据