期刊
CHIRALITY
卷 21, 期 1E, 页码 E110-E115出版社
WILEY
DOI: 10.1002/chir.20788
关键词
vibrational circular dichroism; VCD; keto-enol tautomerism; racemization; DFT calculation; aroma; absolute configuration
A mixture of tautomers with unique keto-enol structures, 5-ethyl-4-hydroxy-2-methylfuran-3(2H)-one and 2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one (EHMF, homofuraneol, 1a and 1b), comprises four structural isomers including their enantiomers. The four isomers were successfully separated by chromatographic optical resolution, and their odor evaluation was performed. Determination of the absolute chemistry of 1a and 1b were accomplished for the first time by direct measurement of the VCD spectra of their methyl ether derivatives 4a and 4b compared with the calculated ones as well as chemical relay reaction. The relationship between odor characteristics and stereochemistry was also examined. Chirality 21:E110-E115, 2009. (C) 2009 Wiley-Liss, Inc.
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