Article
Biochemical Research Methods
Yajie Meng, Changcheng Lu, Min Jin, Junlin Xu, Xiangxiang Zeng, Jialiang Yang
Summary: In this study, a novel neural collaborative filtering approach is proposed for drug repositioning, which utilizes deep-learning approaches based on a heterogeneous network. The approach takes advantage of localized information in different networks and models the complex drug-disease associations effectively. The effectiveness of the approach is verified through benchmarking comparisons and validated against clinical trials and authoritative databases.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Maria Monticelli, Ludovica Liguori, Mariateresa Allocca, Andrea Bosso, Giuseppina Andreotti, Jan Lukas, Maria Chiara Monti, Elva Morretta, Maria Vittoria Cubellis, Bruno Hay Mele
Summary: Fabry disease is a condition caused by a deficiency of lysosomal alpha galactosidase. Researchers have discovered that acetylsalicylic acid, a drug approved for other diseases, can enhance the effectiveness of the pharmacological chaperone therapy for Fabry disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yoonbee Kim, Yi-Sue Jung, Jong-Hoon Park, Seon-Jun Kim, Young-Rae Cho
Summary: Drug repositioning, utilizing heterogeneous networks, is an effective approach to identify new therapeutic indications for approved drugs. This review summarizes network-based methods, including graph mining, matrix factorization, and deep learning, for predicting drug-disease associations. A comparison of predictive performances was conducted, revealing that methods in the graph mining and matrix factorization categories performed well overall.
Article
Biochemical Research Methods
Hailin Chen, Zuping Zhang, Jingpu Zhang
Summary: This research utilized integrated drug features to improve the accuracy of drug repositioning and proposed a fusion method. The results showed that the integration of similarity measurements had the best performance in predicting drug-disease associations.
BMC BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Yoonbee Kim, Young-Rae Cho
Summary: Drug repositioning, which identifies new therapeutic indications for existing drugs, has the advantage of reducing cost and time of drug discovery. This article proposes a network-based method that integrates drug-disease, drug-gene, and disease-gene associations to predict drug-gene-disease associations through tensor decomposition. Experimental results show that the proposed method outperforms existing models in triple association prediction and also achieves competitive accuracy in pairwise association prediction.
Article
Biochemical Research Methods
Lijun Cai, Changcheng Lu, Junlin Xu, Yajie Meng, Peng Wang, Xiangzheng Fu, Xiangxiang Zeng, Yansen Su
Summary: The study introduces a novel method for drug repositioning based on graph convolutional network, which effectively discovers potential drugs. By designing feature extraction modules and attention mechanism, higher prediction performance is achieved. Experiments demonstrate the superior performance of this method in multiple benchmark datasets, identifying several novel drugs for disease treatment.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biochemical Research Methods
Fei Wang, Yulian Ding, Xiujuan Lei, Bo Liao, Fang-Xiang Wu
Summary: Drug repositioning is an important method for exploring new uses of existing drugs in drug discovery, especially in pre-clinical stages. Computational approaches, including machine learning and deep learning, have shown great potential in saving time and reducing costs compared to traditional drug discovery methods.
CURRENT BIOINFORMATICS
(2022)
Review
Biochemical Research Methods
Huimin Luo, Min Li, Mengyun Yang, Fang-Xiang Wu, Yaohang Li, Jianxin Wang
Summary: Drug repositioning, through computational methods, can systematically identify potential drug-target interactions and drug-disease interactions, significantly reducing cost and duration. This review summarizes available biomedical data and public databases, discusses various drug repositioning approaches, and analyzes common data sets and evaluation metrics used in this field.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Mengyun Yang, Gaoyan Wu, Qichang Zhao, Yaohang Li, Jianxin Wang
Summary: This study proposes a multi-similarities bilinear matrix factorization (MSBMF) method to predict drug-associated indications. By concatenating multiple similarity matrices and utilizing matrix factorization, effective latent features are extracted to infer drug-disease associations. Numerical experiments show that MSBMF outperforms state-of-the-art drug repositioning methods in prediction accuracy, with case studies validating its effectiveness in practical applications.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Biotechnology & Applied Microbiology
Hector Hernandez-Parra, Hernan Cortes, Jose Arturo Avalos-Fuentes, Maria Del Prado-Audelo, Benjamin Floran, Gerardo Leyva-Gomez, Javad Sharifi-Rad, William C. Cho
Summary: Parkinson's disease significantly impacts patients' quality of life and healthcare systems economically. Drug repositioning offers new medication alternatives for PD and reduces research time and costs. This review collected evidence of potential candidate drugs for reuse in PD and proposed the reformulation of these drugs into nanocarriers for future repositioning trials. The study also suggested functionalizing the surface of nanoparticles to enhance their ability to cross the blood-brain barrier and improve their affinity for specific brain regions. The main parameters for designing nanoparticles targeting the central nervous system were highlighted.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Guojun Sun, Dashun Dong, Zuojun Dong, Qian Zhang, Hui Fang, Chaojun Wang, Shaoya Zhang, Shuaijun Wu, Yichen Dong, Yuehua Wan
Summary: Drug repurposing has become an effective approach to drug discovery. This study provides a bibliometric analysis of drug repurposing publications from 2010 to 2020. The findings show that the United States leads in this area of research, followed by China, the United Kingdom, and India. The Chinese Academy of Science published the most research studies, and NIH ranked first on the h-index. COVID-19/SARS-CoV-2/coronavirus is the most popular topic for current drug repurposing research.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sha Zhu, Qifeng Bai, Lanqing Li, Tingyang Xu
Summary: Drug repositioning plays a significant role in drug development and machine learning methods can accelerate this process. This article focuses on the repurposing potential of type 2 diabetes mellitus drugs for various diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Boshi Huang, Yan Zhang
Summary: Given the high cost and low success rate of drug discovery and development, repositioning existing drugs for new diseases has become a popular research area. Natural products have shown potential in this field due to their long history of use in various medical purposes. This review discusses the repositioning of six typical natural products and their derivatives to discover new drug-disease associations, while also highlighting the opportunities and challenges in natural product-based drug repositioning for future reference.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Sandra Brasil, Mariateresa Allocca, Salvador C. M. Magrinho, Ines Santos, Madalena Raposo, Rita Francisco, Carlota Pascoal, Tiago Martins, Paula A. Videira, Florbela Pereira, Giuseppina Andreotti, Jaak Jaeken, Kristin A. Kantautas, Ethan O. Perlstein, Vanessa dos Reis Ferreira
Summary: Advances in research have led to the development of therapy for congenital disorders of glycosylation (CDG). Drug repositioning, especially with the help of artificial intelligence, accelerates the overall drug discovery process and saves costs, making it particularly valuable for rare diseases. AI has proven its worth in diagnosis, disease classification, and therapy discovery for rare diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Bo-Wei Zhao, Xiao-Rui Su, Peng-Wei Hu, Yu-Peng Ma, Xi Zhou, Lun Hu
Summary: Drug repositioning is a strategy that uses artificial intelligence techniques to discover new indicators for approved drugs and improve traditional drug discovery and development. However, most computational methods fail to consider the non-Euclidean nature of biomedical network data. To address this, a deep learning framework called DDAGDL is proposed to predict drug-drug associations. Experimental results show that this method outperforms state-of-the-art drug repositioning methods in terms of several evaluation metrics.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Tianyi Qiu, Jingxuan Qiu, Jun Feng, Dingfeng Wu, Yiyan Yang, Kailin Tang, Zhiwei Cao, Ruixin Zhu
BRIEFINGS IN BIOINFORMATICS
(2017)
Article
Multidisciplinary Sciences
Tianyi Qiu, Yiyan Yang, Jingxuan Qiu, Yang Huang, Tianlei Xu, Han Xiao, Dingfeng Wu, Qingchen Zhang, Chen Zhou, Xiaoyan Zhang, Kailin Tang, Jianqing Xu, Zhiwei Cao
NATURE COMMUNICATIONS
(2018)
Article
Pharmacology & Pharmacy
Tanyi Qiu, Dingfeng Wu, LinLin Yang, Hao Ye, Qiming Wang, Zhiwei Cao, Kailin Tang
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemical Research Methods
Qingchen Zhang, Lu Zhang, Chen Zhou, Yiyan Yang, Zuojing Yin, Dingfeng Wu, Kailin Tang, Zhiwei Cao
BMC BIOINFORMATICS
(2019)
Article
Biochemistry & Molecular Biology
Chen Zhou, Zikun Chen, Lu Zhang, Deyu Yan, Tiantian Mao, Kailin Tang, Tianyi Qiu, Zhiwei Cao
NUCLEIC ACIDS RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Jian Gao, Qiming Wang, Yuwei Huang, Kailin Tang, Xue Yang, Zhiwei Cao
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Zikun Chen, Xiaoning Wang, Yuanyuan Li, Yahang Wang, Kailin Tang, Dingfeng Wu, Wenyan Zhao, Yueming Ma, Ping Liu, Zhiwei Cao
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Genetics & Heredity
Zuojing Yin, Xinmiao Yan, Qiming Wang, Zeliang Deng, Kailin Tang, Zhiwei Cao, Tianyi Qiu
FRONTIERS IN GENETICS
(2020)
Article
Cell Biology
Zuojing Yin, Qiming Wang, Xinmiao Yan, Lu Zhang, Kailin Tang, Zhiwei Cao, Tianyi Qiu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Kailin Tang, Xuejie Ji, Mengdi Zhou, Zeliang Deng, Yuwei Huang, Genhui Zheng, Zhiwei Cao
Summary: Although transcriptomics technologies have advanced rapidly in the past decades, integrating mixed data from microarray and RNA-seq remains challenging due to inherent variability differences. Rank-In is a novel method proposed to correct nonbiological effects and enable consolidated analysis of blended data. Validated on public cell and tissue samples, Rank-In demonstrated superior classification and prediction accuracy, showing potential for integrative study of cancer profiles.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Jian Gao, Zuojing Yin, Zhuanbin Wu, Zhen Sheng, Chao Ma, Rui Chen, Xiongwen Zhang, Kailin Tang, Jian Fei, Zhiwei Cao
Summary: This study explored the synergistic effects of Berberine and Evodiamine in hepatocellular carcinoma by co-inhibiting NF-kappa B and c-JUN, which showed significant anticancer activity. The in vivo experiments in zebrafish and analysis of HCC individuals revealed promising results, suggesting the potential of natural compounds for developing combination therapies in combating malignant cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deyu Yan, Genhui Zheng, Caicui Wang, Zikun Chen, Tiantian Mao, Jian Gao, Yu Yan, Xiangyi Chen, Xuejie Ji, Jinyu Yu, Saifeng Mo, Haonan Wen, Wenhao Han, Mengdi Zhou, Yuan Wang, Jun Wang, Kailin Tang, Zhiwei Cao
Summary: HIT 2.0 is a curated dataset focusing on Herbal Ingredients' Targets from PubMed literatures 2000-2020, hosting 10,031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Zikun Chen, Deyu Yan, Mou Zhang, Wenhao Han, Yuan Wang, Shudi Xu, Kailin Tang, Jian Gao, Zhiwei Cao
Summary: This study proposes a method called MetNC for predicting the metabolites of natural compounds (NCs) through simulating in vivo biotransformation. The results show that MetNC performs the best in terms of metabolite coverage and short-listing true products, and it has an additional advantage in recommending microbiota-transformed metabolites.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell Biology
Xinmiao Yan, Yiyan Yang, Zikun Chen, Zuojing Yin, Zeliang Deng, Tianyi Qiu, Kailin Tang, Zhiwei Cao
Article
Biochemical Research Methods
Zhen Sheng, Yi Sun, Zuojing Yin, Kailin Tang, Zhiwei Cao
BRIEFINGS IN BIOINFORMATICS
(2018)