Article
Chemistry, Physical
Mahsa Asgari, Taghi Miri, Meysam Soleymani, Aboulfazl Barati
Summary: This study developed a novel strategy for in situ encapsulation of hydrophobic drugs into magnetite-mesoporous silica nanocomposites. The prepared nanocomposites showed potential for application in magnetic hyperthermia therapy and exhibited pH-responsive drug release behavior. In vitro studies demonstrated that encapsulated curcumin significantly increased cytotoxicity against breast cancer cells compared to free curcumin.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Medicinal
Hong Wang, Wanghao Chen, Guojian Wu, Jun Kong, Shaofei Yuan, Lukui Chen
Summary: The study presents a magnetic T7 peptide&AS1411 aptamer-modified microemulsion for triple glioma-targeted delivery, showing strong antiproliferative effects, superior drug distribution in the brain, and prolonged overall survival. Through specific combination strategies, precise treatment of glioma was achieved successfully.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tom Bellmann, Jana Thamm, Uwe Beekmann, Dana Kralisch, Dagmar Fischer
Summary: In this study, a formulation approach was developed to incorporate lipophilic drugs into bacterial nanocellulose using in situ precipitation of poly(lactic-co-glycolic acid). The best-performing solvents were N-methyl-2-pyrrolidone and ethyl lactate, which led to the formation of homogenously distributed polymer microparticles within the cellulose matrix. The material exhibited sustained release of highly lipophilic drugs over a period of 10 days.
Article
Polymer Science
Mohammad Sadegh Amini-Fazl
Summary: In this study, PLGA was developed as ISFIs to improve therapeutic efficiency and minimize adverse effects of PTX. Different molecular weights of PLGA were tested for PTX release, which demonstrated specific release mechanisms and kinetics through in vitro experiments and model applications.
Article
Pharmacology & Pharmacy
Indrit Seko, Hayrettin Tonbul, Ece Tavukcuoglu, Adem Sahin, Sedenay Akbas, Hamdullah Yanik, Suleyman Can Ozturk, Gunes Esendagli, Mansoor Khan, Yilmaz Capan
Summary: This study successfully developed and characterized curcumin and docetaxel co-loaded poly lactide-co-glycolide nanoparticles to target glioma through improved brain penetration, showing potential for effective treatment by overcoming the blood brain barrier.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sedat Unal, Osman Dogan, Yesim Aktas
Summary: This study aims to develop an oral nanoparticle drug delivery system for the treatment of intestinal tumors. By using poly(lactic-co-glycolic acid) (PLGA) as the nanoparticle material and modified with chitosan (CS) for improved mucoadhesive properties, a nanoparticle formulation that can accumulate in mucus and protect the drug has been designed. In vitro experiments showed that the formulation has favorable nanoparticle size and sustained release characteristics, as well as significant cytotoxicity and permeability, offering a promising and innovative approach for the treatment of intestinal tumors.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yuki Takeuchi, Seiji Obata, Kentaro Ohkura, Yuta Nishina
Summary: By using a template method, we have successfully synthesized silica nanosheets with high specific surface areas and ultrathin thicknesses. This method has the potential to play a significant role in the field of materials science and nanotechnology.
ACS MATERIALS LETTERS
(2022)
Article
Multidisciplinary Sciences
Alaa Khattab, Abdulhakim Nattouf
Summary: This study aims to control the delivery of Tazarotene (TZR) through a microsponge-based gel to reduce adverse effects. By adopting the emulsion solvent diffusion methodology, different formulations of TZR microsponges were developed by varying the concentrations of polymer and emulsifier. The T1 and T3 microsponge formulations showed superior production yield and entrapment efficiency, suitable for dermal application. The optimal formulation, T8 microsponge formulation gel, released 87.63% of TZR over 12 hours.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Zouhair Ait-Touchente, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Noureddine Lebaz, Hatem Fessi, Abdelhamid Elaissari
Summary: Microemulsions are novel drug delivery systems with desirable characteristics for delivering hydrophilic and hydrophobic drugs. This comprehensive review explores various aspects of microemulsions, including formulation, characterization, and applications, with a focus on their potential for cutaneous drug delivery. The review highlights the promise of microemulsions in overcoming bioavailability concerns and enabling sustained drug delivery, emphasizing the importance of understanding their formulation and characterization for optimizing effectiveness and safety. Additionally, the review delves into different types of microemulsions, their composition, and factors affecting their stability, while discussing their potential as drug delivery systems for skin applications.
Review
Pharmacology & Pharmacy
Asghar Narmani, Roghayyeh Jahedi, Ehsan Bakhshian-Dehkordi, Saeid Ganji, Mahnaz Nemati, Ruhollah Ghahramani-Asl, Kave Moloudi, Seyed Mohammad Hosseini, Hamed Bagheri, Prashant Kesharwani, Ali Khani, Bagher Farhood, Amirhossein Sahebkar
Summary: In recent decades, the increasing number of cancer patients has raised serious concerns globally. Nanoparticles-based drug delivery systems, such as poly lactic-co-glycolic acid (PLGA) NPs, have shown great potential in cancer therapy. PLGA NPs, as bioavailable, biocompatible, and biodegradable polymers, have been approved by the FDA for some biomedical and pharmaceutical applications. The preparation approach of PLGA NPs can affect various aspects, including size, solubility, stability, drug loading, pharmacokinetics, and pharmacodynamics.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Jordan B. Joiner, Jasmine L. King, Roopali Shrivastava, Sarah Anne Howard, Mackenzie L. Cottrell, Angela D. M. Kashuba, Paul A. Dayton, Soumya Rahima Benhabbour
Summary: This study investigated the effects of formulation parameters on the in situ forming implant (ISFI) drug delivery system using ultrasound imaging and pharmacokinetics (PK) in mice. The results showed that drug loading extended the degradation time of ISFIs, and there was no statistical difference in drug exposure with different administration routes and injection numbers.
Article
Pharmacology & Pharmacy
Nada Zaghloul, Azza A. Mahmoud, Nermeen A. Elkasabgy, Nada M. El Hoffy
Summary: The aim of this study was to develop an efficient ocular delivery system to enhance the bioavailability of the antifungal drug terconazole. Mesoporous silica microparticles were used as a carrier system, and the addition of PLGA significantly improved the drug release efficiency and bioavailability of terconazole in the eyes. This study highlights the potential of PLGA-modified silica microparticles to enhance the bioavailability of ocular drugs.
Article
Pharmacology & Pharmacy
Cristina de la Torre, Carmen Coll, Amelia Ultimo, Felix Sancenon, Ramon Martinez-Manez, Eduardo Ruiz-Hernandez
Summary: A novel combination of in situ-forming hydrogels and gated mesoporous materials was developed for designing depots that can locally sustainably release chemotherapeutics. The depot is composed of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles capped with polyethylene glycol chains containing a disulfide bond. The nanoparticles are able to deliver the cargo in the presence of the reducing agent glutathione, promoting pore opening and cargo delivery. Release studies and cellular assays demonstrated the successful liberation of the nanoparticles and their internalization into cells, leading to significant reduction in cell viability when loaded with doxorubicin. This research opens up possibilities for the development of new depots combining the tunable properties of hyaluronic gels with a wide range of gated materials for enhanced local controlled release of chemotherapeutics.
Article
Polymer Science
Niannian Lv, Xiaoyan Yin, Zhuoran Yang, Teng Ma, Huimin Qin, Bijin Xiong, Hao Jiang, Jintao Zhu
Summary: The precise control of diacetylene-containing peptide amphiphile (DPA) based supramolecular architectures is crucial for their polymerization behaviors and biomedical applications. This study explores the opposite polymerization behaviors of two DPAs with similar molecular structures and emphasizes the role of charge properties in their polymerization and cell interactions.
Article
Materials Science, Biomaterials
Mark Rutschmann, Natalja Redinger, Ulrich E. Schaible, Claus Feldmann
Summary: AMC@SiO2 core@shell nanocarriers with a high drug load of 0.8 mg mg(-1) are prepared using a solvent-antisolvent approach. The nanocarriers have a mean diameter of 240 nm, with an inner AMC core of 200 nm and an outer silica shell of 20 nm. The size, structure, and composition of the nanocarriers are confirmed by various characterization methods. The AMC@SiO2 core@shell nanocarriers show promising potential for the treatment of multidrug resistant bacterial pathogens.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Xueyu Wang, Shaobo Wang, Jiao Gao, Shuncheng Yao, Teng Xu, Yunchao Zhao, Zeyu Zhang, Tian Huang, Shu Yan, Linlin Li
Summary: By designing a new kind of Met-capped CuOHCl nanosheets, the bacteria can be effectively killed at low concentration and short treatment time, resulting in accelerated wound healing.
Article
Nanoscience & Nanotechnology
Minjia Zheng, Shuncheng Yao, Yunchao Zhao, Xingyi Wan, Quanhong Hu, Chuyu Tang, Zhuoheng Jiang, Shaobo Wang, Zhirong Liu, Linlin Li
Summary: A self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy is proposed by integrating a human-driven triboelectric nanogenerator (TENG) with an implantable and biodegradable nanofibrous patch. The patch incorporates doxorubicin (DOX) and graphitic carbon nitride (gC3N4) to enhance the peroxidase (POD)-like activity of g-C3N4 and release DOX under a weakly acidic tumor microenvironment (TME), achieving synergistic therapy. The in vitro and in vivo experimental results demonstrate superior tumor suppression outcome and suggest a new complementary strategy for catalytic therapy of solid tumors using multifunctional nanofibrous patches.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Zhuo Wang, Xi Liang, Zhirong Liu, Tian Huang, Shaobo Wang, Shuncheng Yao, Yiming Ding, Jiaming Zhang, Xingyi Wan, Zhong Lin Wang, Linlin Li
Summary: This study presents a new self-powered and high-efficient electrochemical system for water treatment. By integrating a triboelectric nanogenerator (TENG) and a two-dimensional Co(OH)(2)/Pt nanosheet as electrocatalyst, it can efficiently degrade organic pollutants and kill bacteria in a short period of time.
Review
Engineering, Biomedical
Songjing Zhong, Shuncheng Yao, Qinyu Zhao, Zhuo Wang, Zhirong Liu, Linlin Li, Zhong Lin Wang
Summary: Inspired by endogenous physiological electric fields in humans, electricity has been widely used as a accessible source of physical stimulation to help treat diseases, including cancer therapy. Many studies have proved that the electrical stimulation can mobilize the body's immune system to kill tumors through different mechanisms. This review comprehensively summarizes these developments from clinic applications to new emerging strategies and proposes future challenges and opportunities in this field.
ADVANCED NANOBIOMED RESEARCH
(2023)
Article
Engineering, Environmental
Hongqiang Chen, Yonghai Zhang, Lei Huang, Xiong Zhao, Xiang Ma, Zihuan Ma, Junsheng Hou, Jinjia Wei, Paolo Di Marco, Omid Mahian, Nanjing Hao
Summary: This article presents a simple and straightforward microfluidic strategy for synthesizing functional silica nanofluids with excellent stability. The use of these nanofluids in microchannel flow boiling significantly enhances the heat transfer coefficient and critical heat flux, providing a promising solution for thermal management in high-power electronics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Yunchao Zhao, Tian Huang, Shaobo Wang, Shuncheng Yao, Quanhong Hu, Xingyi Wan, Ning Guo, Yang Zhang, Linlin Li
Summary: Sonodynamic therapy (SDT) is a promising strategy for cancer treatment, but the inefficient production of reactive oxygen species (ROS) limits its applications. This study developed a piezoelectric nanoplatform with manganese oxide (MnOx) and bismuth oxychloride nanosheets (BiOCl NSs) to enhance SDT. The nanoplatform exhibited piezotronic effect to promote charge separation and transport, leading to enhanced ROS generation. Additionally, the MnOx on the nanoplatform showed multiple enzyme-like activities, which downregulated intracellular glutathione (GSH) level and disintegrated hydrogen peroxide (H2O2) to generate oxygen (O2) and hydroxyl radicals (.OH). The nanoplatform demonstrated excellent biocompatibility and tumor suppression in a murine model of 4 T1 breast cancer under ultrasound irradiation. This work presents a feasible pathway for improving SDT using piezoelectric platforms.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yiming Ding, Yunchao Zhao, Shuncheng Yao, Shaobo Wang, Xingyi Wan, Quanhong Hu, Linlin Li
Summary: Sonodynamic therapy (SDT) is a promising cancer treatment strategy with low invasiveness and high tissue penetration. However, the lack of efficient sonosensitizers has hindered its application. In this study, iron-doped and oxygen-deficient bismuth tungstate nanosheets (BWO-Fe NSs) with piezotronic effect were synthesized to enhance SDT. The presence of oxygen defects and Fenton reactivity in BWO-Fe improved its activation by ultrasound and amplified the cellular oxidative damage.
Article
Nanoscience & Nanotechnology
X. Zhao, H. Chen, Y. Xiao, J. Zhang, S. Watanabe, N. Hao
Summary: Acoustic microfluidics has a significant influence on mixing but faces challenges of low throughput. A robust acoustic micromixer is proposed, which integrates acoustics with hydrodynamics for fast and homogeneous mixing at various flow rates. The study shows the correlation between mixing performance and transducer properties, and the micromixer is used to synthesize functional ZnO nanoarrays with controllable properties.
MATERIALS TODAY NANO
(2023)
Article
Nanoscience & Nanotechnology
Shuncheng Yao, Yunchao Zhao, Zhuo Wang, Shaobo Wang, Minjia Zheng, Quanhong Hu, Linlin Li
Summary: Ultrasound-triggered sonodynamic therapy (SDT) is a promising method for cancer treatment due to its non-invasive nature and high tissue penetration ability. However, current sonosensitizers have low yields of free radicals. In this study, organic semiconductor π-conjugated covalent organic framework nanocages (COFNs) were developed as efficient sonosensitizers to enhance free radical production and improve cancer therapy. The COFNs exhibited significantly improved SDT performance through enhanced electron utilization and cavitation effect, resulting in increased ultrasound pressure and O-1(2) production. In vitro and in vivo experiments confirmed the elevated SDT performance, demonstrating high tumor suppression in refractory breast cancer. This work provides a promising strategy to develop high-performance sonosensitizers for cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Songjing Zhong, Cheng Xiong, Yunchao Zhao, Shuncheng Yao, Quanhong Hu, Shaobo Wang, Qinyu Zhao, Linlin Li
Summary: By applying electrical stimulus, the catalytic activities of single-atom copper nanozymes are remarkably improved, leading to enhanced oxidative damage and death of cancer cells for improved therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li
Summary: Electric-field-based stimulation is a new cancer therapy method that interferes with cell mitosis. To overcome the limitations of wire connections, bulky devices, and coarse spatial resolution, an implantable, biodegradable, and wirelessly controlled therapeutic triboelectric nanogenerator (ET-TENG) is proposed for delivering electrical stimulation wirelessly.
ADVANCED MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Yaxuan Xiao, Jinhua Zhang, Xiong Zhao, Bin Fang, Li Ma, Nanjing Hao
Summary: In this study, an artificial Chlamydomonas-like acoustics-actuated microrobot was proposed and its acoustic propulsion was verified through numerical simulation and experiments. The impact of tail tip angle and tail spacing on acoustic streaming intensity was investigated, and optimization design was found to improve the microrobot's motion performance.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Multidisciplinary
Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li
Summary: This research proposes an implantable, wirelessly controlled therapeutic nanogenerator that uses ultrasound to generate electrical stimulation and release drugs into tumor tissues. By disrupting cell mitosis and inducing cell death, this device provides a new method for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Songjing Zhong, Zeyu Zhang, Yunchao Zhao, Shaobo Wang, Quanhong Hu, Linlin Li
Summary: Researchers have fabricated bismuth nanoclusters as nanozymes that exhibit both catalytic and photothermal therapy effects. These nanozymes can generate toxic substances and deplete antioxidants in the tumor microenvironment, leading to remarkable antitumor effects.
Article
Chemistry, Physical
Zhuo Wang, Xi Liang, Zhirong Liu, Tian Huang, Shaobo Wang, Shuncheng Yao, Yiming Ding, Jiaming Zhang, Xingyi Wan, Zhong Lin Wang, Linlin Li
Summary: This study presents a self-powered and high-efficient electrochemical system for water treatment, which includes pollutant degradation and bacterial inactivation. The system converts mechanical energy into electrical energy and utilizes nanocatalysts to efficiently degrade organic pollutants and kill bacteria.
