Article
Engineering, Biomedical
Ruhao Wang, Cunfeng Song, Ang Gao, Qianwen Liu, Wenbin Guan, Jiawei Mei, Lijun Ma, Daxiang Cui
Summary: In this study, monoclonal antibody-conjugated liposomes loaded with indocyanine green (ICG) were developed for targeted photoacoustic imaging-guided sonodynamic therapy of Helicobacter pylori infection. The treatment successfully recognized and eliminated H. pylori without toxicity to normal tissues.
ACTA BIOMATERIALIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pengfei Li, Jiaqi Liu, Kunshan He, Shipeng Gong, Chongwei Chi, Pan Liu, Guidong Su, Weili Li, Hui Duan, Ping Liu, Jie Tian, Chunlin Chen
Summary: The feasibility and accuracy of near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) for detecting tumor invasion in cervical cancer was investigated. NIRF imaging enabled objective and accurate identification of tumor invasion during cervical cancer surgery.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
M. Atif, Lothar Lilge, Atif Hanif, Shafiq Ahmad, S. Devanesan
Summary: Photoacoustic imaging is an evolving modality for studying and imaging tumor hypoxia. Experimental results show a short-term increase followed by a strong decrease in the tumor vasculature after Photodynamic Therapy (PDT), but no complete stasis. An alternate method is developed by analyzing the spatial and frequency domain histogram of the tumor vasculature using two-dimensional Fast Fourier Transform (FFT). The variations in acoustic impedance and hemoglobin levels after PDT are studied, and their impact on tumor necrosis is investigated.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Review
Oncology
Masaki Kaibori, Kosuke Matsui, Mikio Hayashi
Summary: Lactosomes (TM) are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. They can be loaded with imaging probes and anticancer agents, functioning as a photosensitizer for both diagnosis and photodynamic therapy, ultimately improving the quality of life for patients.
Article
Chemistry, Analytical
Xin Sun, Han Shan, Qibo Lin, Ziyan Chen, Dongxu Liu, Zhankai Liu, Kuan Peng, Zeyu Chen
Summary: This study utilized ICG-Lips and a dual-wavelength photoacoustic computed tomography (PACT) system to visualize the aggregation of ICG-Lips in tumors in real time, providing guidance for phototherapy. The work highlights the potential of PACT in real-time monitoring of in vivo drug distribution.
Article
Multidisciplinary Sciences
Rongkang Gao, Feng Liu, Wenfeng Liu, Silue Zeng, Jingqin Chen, Ruru Gao, Liang Wang, Chihua Fang, Liang Song, Adam C. Sedgwick, Jonathan L. Sessler, Jun Chu, Fei Yan, Chengbo Liu
Summary: This study developed a tumor-targeting delivery system using tumor-homing bacteria as carriers to deliver genetically encoded photochromic probes to the tumor area in order to eliminate background signals in photoacoustic imaging. The system integrated a genetically encoded reporter protein, photoacoustic imaging, and synthetic biology to achieve background-suppressed tumor-targeted imaging in deep-seated tissues, enabling more sensitive, accurate, and specific cancer diagnoses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Naoya Yokota, Tetsuhiko Go, Atsushi Fujiwara, Ayumu Kato, Yasuhiro Otsuki, Hiroyasu Yokomise
Summary: This study developed a new sealing test method involving the administration of aerosolized indocyanine green into the airway to identify alveolar-pleural fistulas. The experimental results showed that this method could effectively locate pleural defects in a canine model and is suitable for video-assisted thoracic surgery.
ANNALS OF THORACIC SURGERY
(2021)
Article
Dermatology
Yushi Suzuki, Hiroki Kajita, Moemi Urano, Shiho Watanabe, Marika Otaki, Yoshifumi Takatsume, Hisashi Sakuma, Nobuaki Imanishi, Kazuo Kishi
Summary: By using photoacoustic lymphangiography (PAL), we measured the depth of lymphatic vessels and found that the lymphatic vessels were deeper in patients with lymphedema compared to the healthy group. This study is important for lymphatic surgeons as it can assist in the identification of functional lymphatic vessels for better lymphaticovenular anastomosis in lymphedema cases.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kiyoko Takemiya, Joachim J. Roise, Maomao He, Chung Taing, Alexander G. Rodriguez, Niren Murthy, Mark M. Goodman, W. Robert Taylor
Summary: The study demonstrates that MH-ICG can be used to detect Staphylococcus aureus infection in infectious endocarditis with high specificity. It shows good efficiency in vivo in rats and can significantly accumulate in bacterial vegetations.
Article
Biochemical Research Methods
Van Phuc Nguyen, Jeff Folz, Yanxiu Li, Jessica Henry, Wei Zhang, Thomas Qian, Xueding Wang, Yannis M. Paulus
Summary: The combination of photoacoustic microscopy with indocyanine green and RGD peptides enables targeted imaging of CNV, improving imaging sensitivity and contrast, offering new insights for ophthalmology.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Oncology
Kyungsu Kim, Kook Nam Han, Byeong Hyeon Choi, Jiyun Rho, Jun Hee Lee, Jae Seon Eo, Chungyeul Kim, Beop-Min Kim, Ok Hwa Jeon, Hyun Koo Kim
Summary: The feasibility of using Indocyanine green (ICG) to detect metastatic lymph nodes and tumors was evaluated in both animal and clinical studies. ICG successfully detected metastatic lymph nodes and tumors. However, due to its low fluorescence, it may be challenging to detect tumors in vivo using ICG.
Article
Biochemical Research Methods
Kwok-Ho Lui, Shiying Li, Wai-sum Lo, Yanjuan Gu, Wing-Tak Wong
Summary: Photoacoustic imaging combined with slit lamp microscopy can effectively detect corneal neovascularization and provide objective data. Untreated corneas showed higher oxygen saturation levels compared to treatment groups. These results suggest that photoacoustic imaging can serve as an effective method for monitoring CNV progression and treatment outcomes.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Acoustics
Tingting Qiu, Chihan Peng, Lin Huang, Jinge Yang, Wenwu Ling, Jiawu Li, Hongjin Xiang, Yan Luo
Summary: Liver function reserve (LFR) is crucial in liver disease patients. The standard method for LFR evaluation is indocyanine green (ICG) clearance test, which can be performed using spectrophotometry or pulse dye densitometry (PDD). This study compared the accuracy of photoacoustic imaging (PAI) and PDD for LFR assessment in healthy volunteers, using spectrophotometry as the reference standard. The results showed a strong correlation between PAI and spectrophotometry (r = 0.9649, p < 0.0001). There was no significant difference in ICG clearance between PAI and spectrophotometry. These findings suggest that PAI could be a valuable noninvasive and accurate diagnostic tool for LFR assessment in humans.
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Biotechnology & Applied Microbiology
Jinsheng Jiang, Chuqi Yuan, Jiaxi Zhang, Zhuojun Xie, Jiaying Xiao
Summary: This study presents a cross-scale endoscopic imaging system for rectal tumors using a combined photoacoustic/ultrasound tomography system and wide-field optical microscopy. The system offers advantages such as deep penetration, multi-spectral imaging, cross-scale imaging ability, low cost, and 360-degree view. Results showed that the system accurately depicts the location of cancer invasion depth spectroscopically and identifies tumor angiogenesis in the wide-field optical imaging mode. This work could enhance the characterization of colorectal cancer and promote the clinical application of photoacoustic-based colorectal endoscopy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
