Article
Gastroenterology & Hepatology
Luoyan Ai, Yimeng Ren, Mingming Zhu, Shiyuan Lu, Yun Qian, Zhaofei Chen, Antao Xu
Summary: Synbindin is a key regulator of TLR4 signaling and restrains proinflammatory macrophage activation against microbiota during colitis, indicating a potential therapeutic target for inflammatory bowel disease.
Article
Biochemistry & Molecular Biology
Dong Zhan, Andrew Cross, Helen L. Wright, Robert J. Moots, Steven W. Edwards, Sittisak Honsawek
Summary: Neutrophil-derived microvesicles (NDMVs) have the potential to exert anti-inflammatory effects by inhibiting broad-spectrum proinflammatory cytokine secretion stimulated by TNF alpha in fibroblast-like synoviocytes. This suggests a potential therapeutic role of NDMVs in regulating the function of synoviocytes in rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Kleio-Maria Verrou, Nikolaos Vlachogiannis, Giannis Ampatziadis-Michailidis, Panagiotis Moulos, Georgios A. Pavlopoulos, Pantelis Hatzis, George Kollias, Petros P. Sfikakis
Summary: Transcriptome analysis in BD patients' blood mononuclear cells revealed significant upregulation and downregulation of genes, particularly related to neutrophil chemotaxis. This suggests a prominent enhancement of innate immune responses in BD, with a central role played by upregulated neutrophils.
Review
Immunology
Meghan L. De Meo, Jonathan D. Spicer
Summary: NETs play a pro-tumorigenic role in cancer by promoting tumor cell proliferation, immunosuppression, cancer associated thrombosis, and metastasis through their contributions to epithelial-to-mesenchymal transition in tumor cells. Additionally, NETs present in pre-metastatic niches can impact tumor cell recruitment and dormant cell reawakening, favoring metastatic growth. Anti-NET therapies are being explored as a potential treatment option in cancer to synergize with existing anti-cancer therapies.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Immunology
Graeme P. Sullivan, Pavel Davidovich, Natalia Munoz-Wolf, Ross W. Ward, Yasmina E. Hernandez Santana, Danielle M. Clancy, Aoife Gorman, Zaneta Najda, Boris Turk, Patrick T. Walsh, Ed C. Lavelle, Seamus J. Martin
Summary: IL-37, a member of the IL-1 family, can be activated and exhibit proinflammatory effects upon processing by specific proteases. This finding is consistent with other IL-1 family members.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Miguel A. Zarate, Robyn K. De Dios, Durganili Balasubramaniyan, Lijun Zheng, Laura G. Sherlock, Paul J. Rozance, Clyde J. Wright
Summary: The study shows that intrauterine growth restriction (IUGR) has a negative impact on neonatal immunity, leading to a weakened acute inflammatory response to inflammatory stimuli.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yunxi Yang, Lu Liu, Zaiwen Guo, Jiamin Huang, Linbin Li, Yiming Shao, Mingming Song, Aixiang Yang, Bingwei Sun
Summary: This study aimed to evaluate the chemotactic function of neutrophils in patients with severe infections and found that infections significantly impaired the chemotactic function of neutrophils. CD and CFS were significantly negatively correlated with severity scores, inflammation markers concentrations, and gene expression.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Tso-Fu Wang, Yu-Shan Liou, Hsin-Hou Chang, Shang-Hsien Yang, Chi-Cheng Li, Jen-Hung Wang, Der-Shan Sun
Summary: This study investigated the correlation between body mass index (BMI), proinflammatory cytokine levels, and hematopoietic stem cell (HSC) mobilization triggered by granulocyte colony-stimulating factor (G-CSF). The results showed that BMI was positively correlated with G-CSF-induced HSC mobilization, and good mobilizers had higher BMI and proinflammatory cytokine levels compared to poor mobilizers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Judah Glogauer, Chunxiang Sun, Yongqiang Wang, Michael Glogauer
Summary: Adseverin plays a crucial role in neutrophil chemotaxis by regulating F-actin assembly through generating free barbed ends at the leading edge. Knockout of Adseverin results in reduced migration speed of neutrophils.
Article
Immunology
Po-Tsang Lee, Fan-Hua Nan, Po-Yu Chiu, Chung-Chih Tseng, Meng-Chou Lee
Summary: This study examined the effects of Sarcodia suiae water extract (SSWE) on cobia, and found that SSWE treatment can enhance the fish's immune response against pathogens and has the potential to be used as an immunostimulant and vaccine adjuvant for fish.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Yihan Zhang, Tian Lin, Hui Min Leung, Cheng Zhang, Brittany Wilson-Mifsud, Michael B. Feldman, Anne Puel, Fanny Lanternier, Louis-Jean Couderc, Francois Danion, Emilie Catherinot, Helene Salvator, Colas Tcherkian, Claire Givel, Jie Xu, Guillermo J. Tearney, Jatin M. Vyas, Hu Li, Bryan P. Hurley, Hongmei Mou
Summary: This study found that AD-HIES STAT3 mutations lead to abnormal airway basal cells, affecting cell proliferation, differentiation, barrier function, and bacterial clearance ability, as well as immune responses to infection. These results emphasize the importance of STAT3 mutations in the pathogenesis of lung complications and suggest that treatment should address both epithelial and immune cell defects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xian Yu, Stephen A. Newland, Tian X. Zhao, Yuning Lu, Andrew S. Sage, Yanyi Sun, Rouchelle S. Sriranjan, Marcella K. L. Ma, Brian Y. H. Lam, Meritxell Nus, James E. Harrison, Simon J. Bond, Xiang Cheng, Jean-Sebastien Silvestre, James H. F. Rudd, Joseph Cheriyan, Ziad Mallat
Summary: ILC2s play a critical role in cardiac healing and improvement of heart function after myocardial infarction. Activation of ILC2 using low-dose IL-2 could be a novel therapeutic strategy to promote a reparative response after MI.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Prakash Sah, Bailey A. Knighten, Megan A. Reidy, Lauren A. Zenewicz
Summary: This study demonstrates that C. difficile toxin B activates ILC3s by upregulating the polyamine biosynthesis pathway, resulting in high levels of IL-22 secretion. This finding provides insights into the immune response against bacterial infections mediated by ILC3s.
INFECTION AND IMMUNITY
(2023)
Article
Chemistry, Medicinal
Xuewu Liang, Yongle Xie, Xuyi Liu, Hui Xu, Hairu Ren, Shuai Tang, Qi Liu, Min Huang, Xueqing Shao, Chunpu Li, Yu Zhou, Meiyu Geng, Zuoquan Xie, Hong Liu
Summary: This study discovered a series of compounds that can potentially inhibit both JAK/STAT and NF-kappa B signaling pathways, revealing their potential for the treatment of inflammatory bowel disease (IBD).
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Rheumatology
F. M. Mariani, I. Martelli, F. Pistone, E. Chericoni, I. Puxeddu, A. Alunno
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in both specific joints and the whole body. Recent research has uncovered new mechanisms involved in the development and progression of RA, providing new potential targets for treatment. This review article summarizes the insights gained from original research published in the past year regarding the pathogenesis of RA.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Cell & Tissue Engineering
Christopher B. Driscoll, Jason M. Tonne, Moustafa El Khatib, Roberto Cattaneo, Yasuhiro Ikeda, Patricia Devaux
STEM CELL RESEARCH & THERAPY
(2015)
Article
Biotechnology & Applied Microbiology
Kevin G. Shim, Shane Zaidi, Jill Thompson, Tim Kottke, Laura Evgin, Karishma R. Rajani, Matthew Schuelke, Christopher B. Driscoll, Amanda Huff, Jose S. Pulido, Richard G. Vile
Article
Biotechnology & Applied Microbiology
H. V. Reddi, C. B. Driscoll, P. Madde, D. Milosevic, R. M. Hurley, S. J. McDonough, J. Hallanger-Johnson, B. McIver, N. L. Eberhardt
CANCER GENE THERAPY
(2013)
Article
Oncology
Amanda L. Huff, Phonphimon Wongthida, Timothy Kottke, Jill M. Thompson, Christopher B. Driscoll, Matthew Schuelke, Kevin G. Shim, Reuben S. Harris, Amy Molan, Jose S. Pulido, Peter J. Selby, Kevin J. Harrington, Alan Melcher, Laura Evgin, Richard G. Vile
MOLECULAR THERAPY-ONCOLYTICS
(2018)
Article
Oncology
Laura Evgin, Amanda L. Huff, Timothy Kottke, Jill Thompson, Amy M. Molan, Christopher B. Driscoll, Matthew Schuelke, Kevin G. Shim, Phonphimon Wongthida, Elizabeth J. Ilett, Karen Kaluza Smith, Reuben S. Harris, Matt Coffey, Jose S. Pulido, Hardev Pandha, Peter J. Selby, Kevin J. Harrington, Alan Melcher, Richard G. Vile
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Oncology
Matthew R. Schuelke, Phonphimon Wongthida, Jill Thompson, Timothy Kottke, Christopher B. Driscoll, Amanda L. Huff, Kevin G. Shim, Matt Coffey, Jose Pulido, Laura Evgin, Richard G. Vile
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Multidisciplinary Sciences
Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Timothy Kottke, Jason Tonne, Laura Evgin, Christopher B. Driscoll, Jacob van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady Zell, Jill M. Thompson, Phonphimon Wongthida, Jose Pulido, Matthew R. Schuelke, Adel Samson, Peter Selby, Elizabeth Ilett, Mark McNiven, Lewis R. Roberts, Mitesh J. Borad, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard G. Vile
Summary: The study shows that tumors escaping oncolytic therapy with VSV-IFN beta express a mutated form of the CSDE1 gene which inhibits viral replication. However, this mutation also generates a neoantigen that can be targeted for immunotherapy against treatment-resistant tumors.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Laura Evgin, Tim Kottke, Jason Tonne, Jill Thompson, Amanda L. Huff, Jacob van Vloten, Madelyn Moore, Josefine Michael, Christopher Driscoll, Jose Pulido, Eric Swanson, Richard Kennedy, Matt Coffey, Houra Loghmani, Luis Sanchez-Perez, Gloria Olivier, Kevin Harrington, Hardev Pandha, Alan Melcher, Rosa Maria Diaz, Richard G. Vile
Summary: Combining oncolytic viruses (OVs) and CAR T cell therapy can enhance the efficacy of CAR T cells in the solid tumor microenvironment. Stimulation of the native T cell receptor by viral epitopes can enhance CAR T cell proliferation and antitumor function, leading to prolonged survival.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ramya Rallabandi, Brenna Sharp, Conrad Cruz, Qi Wang, Alexis Locsin, Christopher B. Driscoll, Ella Lee, Tim Nelson, Patricia Devaux
Summary: This study investigates the role of exogenous OCT4 in the reprogramming process and proposes a novel approach using miRNA targeting in a viral vector to control vector-induced processes. The results demonstrate that exogenous OCT4 is required only for the initiation of reprogramming and continuous expression of SOX2, KLF4, and c-MYC is necessary for the maturation stage of iPSC. The application of miRNA targeting in a viral vector shows potential for improving the efficiency of reprogramming.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)