Survival of Effector CD8+T Cells during Influenza Infection Is Dependent on Autophagy

Once a killer, always a killer: from cytotoxic T cell to memory cell

(2015) Leo Lefrançois et al.   IMMUNOLOGICAL REVIEWS

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Immune Memory–Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections

(2014) Emily L. Goldberg et al.   JOURNAL OF IMMUNOLOGY

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Essential role for autophagy in the maintenance of immunological memory against influenza infection

(2014) Min Chen et al.   NATURE MEDICINE

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Reactive oxygen species delay control of lymphocytic choriomeningitis virus

(2013) P A Lang et al.   CELL DEATH AND DIFFERENTIATION

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory

(2013) F. Tzelepis et al.   JOURNAL OF IMMUNOLOGY

FoxO1 Controls Effector-to-Memory Transition and Maintenance of Functional CD8 T Cell Memory

(2013) M. M. Tejera et al.   JOURNAL OF IMMUNOLOGY

Influenza A Virus Proteins NS1 and Hemagglutinin Along with M2 Are Involved in Stimulation of Autophagy in Infected Cells

(2013) O. P. Zhirnov et al.   JOURNAL OF VIROLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

mTOR, linking metabolism and immunity

(2013) Xiaojin Xu et al.   SEMINARS IN IMMUNOLOGY

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Autophagy, a Novel Pathway to Regulate Calcium Mobilization in T Lymphocytes

(2013) Wei Jia et al.   Frontiers in Immunology

Glutathione Peroxidase-1 Reduces Influenza A Virus–Induced Lung Inflammation

(2012) Selcuk Yatmaz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

From crucial to negligible: Functional CD8+T-cell responses and their dependence on CD4+T-cell help

(2012) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Selective Autophagy of the Adaptor Protein Bcl10 Modulates T Cell Receptor Activation of NF-κB

(2012) Suman Paul et al.   IMMUNITY

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation

(2012) E. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Macroautophagy in T Lymphocyte Development and Function

(2012) Ming-Xiao He et al.   Frontiers in Immunology

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Regulation of T-cell survival and mitochondrial homeostasis by TSC1

(2011) Thomas F. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

(2011) Shan He et al.   PLoS One

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

(2010) Tsunehiko Yoshida et al.   FASEB JOURNAL

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data

(2010) Ahmed Essaghir et al.   NUCLEIC ACIDS RESEARCH

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis

(2010) B J Altman et al.   ONCOGENE

Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

(2010) Nadine Werth et al.   PLoS One

Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival

(2010) T. W. Hand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification ofAtg5-dependent transcriptional changes and increases in mitochondrial mass inAtg5-deficient T lymphocytes

(2009) Linda M. Stephenson et al.   Autophagy

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH