Article
Medicine, Research & Experimental
Rubia Isler Mancuso, Juliana Hofstatter Azambuja, Sara Teresinha Olalla Saad
Summary: This study demonstrates that ART pretreatment effectively prevents inflammation induced by LPS, protecting the body from inflammatory damage by regulating various immune cell types, reducing inflammatory cytokines and chemokines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Allergy
Doumet Georges Helou, Christine Quach, Marshall Fung, Jacob D. Painter, Benjamin P. Hurrell, Yong-Hwee Eddie Loh, Emily Howard, Pedram Shafiei-Jahani, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Summary: PD-1 plays a crucial role in regulating acute neutrophilic inflammation, and its deficiency is associated with increased airway hyperreactivity and lung inflammation. Conversely, PD-1 agonist treatment can effectively alleviate these pathological responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sebastian Bittner, Brigitte Ruhland, Veronika Hofmann, Lisa Schmidleithner, Kathrin Schambeck, Asmita Pant, Philipp Stueve, Michael Delacher, Bernd Echtenacher, Matthias Edinger, Petra Hoffmann, Michael Rehli, Claudia Gebhard, Nicholas Strieder, Thomas Hehlgans, Markus Feuerer
Summary: In this study, the researchers introduced synthetic biosensors called artificial immune receptors (AIRs) to modulate regulatory T cells (Treg cells). These AIRs enable Treg cells to sense inflammation and activate specific signaling pathways. In animal models, Treg cells expressing AIRs provided better protection against graft-versus-host disease compared to control Treg cells. The expression and signaling of these artificial immune receptors in human Treg cells suggest the potential application of Treg cell-based therapy for various inflammation-driven diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Dermatology
Sabine Ring, Yutaka Inaba, Meihong Da, Tobias Bopp, Stephan Grabbe, Alexander Enk, Karsten Mahnke
Summary: Regulatory T cells can suppress early neutrophil infiltration in contact hypersensitivity reactions by strengthening endothelial cell connections, preventing leakage of inflammatory cells and downregulating immune responses.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Selva Rivas-Arancibia, Eduardo Hernandez-Orozco, Erika Rodriguez-Martinez, Marlen Valdes-Fuentes, Vanessa Cornejo-Trejo, Nelva Perez-Pacheco, Claudia Dorado-Martinez, Diana Zequeida-Carmona, Isaac Espinosa-Caleti
Summary: Ozone pollution leads to chronic oxidative stress which disrupts immune response and inflammation regulation. The imbalance in oxidation-reduction equilibrium contributes to the chronic deterioration of degenerative diseases. Studying the relationship between ozone pollution, oxidative stress, and regulatory T cells provides valuable insights into the impact on inflammatory responses and the role of antioxidant systems in various pathologies.
Article
Immunology
Xue Wen, Siji Nian, Gang Wei, Pengyuan Kang, Yaqi Yang, Lin Li, Yingchun Ye, Lulu Zhang, Songping Wang, Qing Yuan
Summary: This study evaluated the phenotype and function of circulating mucosal-associated invariant T (MAIT) cells in patients with neutrophilic asthma (NA). The results showed that NA patients had significantly decreased frequency of MAIT cells, altered phenotype, and biased Th17 immune response. The study suggests that MAIT cells could be a potential therapeutic target for NA asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Pauline Loos, Jerome Baiwir, Celine Maquet, Justine Javaux, Remy Sandor, Francois Lallemand, Thomas Marichal, Benedicte Machiels, Laurent Gillet
Summary: Immunological dysregulation in asthma is related to early-life exposure to microorganisms. Gamma herpesviruses (gamma HVs) like Epstein-Barr virus, which infect and influence host immunity throughout life, are widespread in humans. In a study using murid herpesvirus 4 (MuHV-4), a mouse gamma HV, it was found that lung-resident and recruited group 2 innate lymphoid cells (ILC2s) had a reduced ability to respond to house dust mites after infection, leading to protection against asthma. The infection also triggered the production of GM-CSF by lung ILC2s, which caused the differentiation of monocytes (Mos) into alveolar macrophages (AMs) without promoting their type 2 functions. This study highlights the essential role of ILC2s in shaping the function and identity of AMs during gamma HV infection.
SCIENCE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hong-yun Wang, Jun-rui Ye, Li-yuan Cui, Shi-feng Chu, Nai-hong Chen
Summary: Recent evidence suggests that regulatory T (Treg) cells play a crucial role in immune regulation after ischemic stroke (IS), but their effects on IS outcomes remain controversial. Further research is needed to elucidate the mechanisms by which Treg cells modulate the immune responses induced by IS.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Immunology
Justin Jacobse, Jing Li, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Summary: Intestinal FOXP3(+) regulatory T cells play a crucial role in maintaining immune balance and preventing autoimmunity in the gut. Dysregulation of these cells can lead to chronic inflammatory disorders, including inflammatory bowel disease, highlighting the importance of understanding their biology for therapeutic interventions. Intestinal Treg cells are not fixed subsets, but rather plastic and responsive to microenvironmental cues, similar to T helper cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Ke-jia Wu, Qu-fei Qian, Jin-ren Zhou, Dong-lin Sun, Yun-fei Duan, Xi Zhu, Kurt Sartorius, Yun-jie Lu
Summary: The human liver plays crucial roles in synthesizing extracellular matrix (ECM) and regulating fibrogenesis for maintaining homeostasis. Chronic liver injury induces fibrogenesis due to the imbalance between ECM accumulation and fibrosis resolution. Liver diseases that cause fibrogenesis are associated with various risk factors, including hepatitis infection, schistosomiasis, alcohol, certain drugs, toxicants, diabetes, and obesity. Hepatic stellate cells (HSCs) activation, which generate and accumulate ECM, is a key event in liver fibrosis. The paper reviews the dual role of regulatory T-cells (Tregs) in liver fibrogenesis, including their promotion of immunosuppression and activation of fibrosis. Understanding the contradictory roles of Tregs in different immune microenvironments and molecular pathways is important for managing liver fibrosis.
CELL DEATH DISCOVERY
(2023)
Review
Immunology
Xinting Wang, Hua Zhou, Qian Liu, Peipei Cheng, Tingyao Zhao, Tianshu Yang, Yue Zhao, Wanjing Sha, Yanyan Zhao, Huiyan Qu
Summary: Cardiovascular diseases (CVDs) are a major cause of global death and disability, with inflammatory progression and immune responses playing a crucial role. Regulatory T cells (Tregs), as a subset of CD4(+)T cells, have immunosuppressive function and are important in inflammatory diseases. Using Tregs as biomarkers or targeting them for cardioprotective effects by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration has become a research focus in CVD treatment. However, Tregs have plasticity and can lose their immunosuppressive function, causing toxic effects on target organs in certain diseases. This review provides an overview of Tregs' role in CVDs, discusses their plasticity, and lays a foundation for future studies targeting Tregs in CVD prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Hong H. T. C. Le, Pham Le An, Nguyen Nhu Vinh, Robert S. Ware, Dung Phung, Phong K. Thai, Sarath Ranganathan, Tran Ngoc Dang, Phan Hoang Thuy Dung, Do Thi Hoai Thuong, Hai Phung, To Thi Hien, Peter D. Sly
Summary: This study assessed the under-recognition of asthma in middle school children in Vietnam. The results showed that over 80% of symptomatic children were not diagnosed with asthma. Under-recognition of asthma was more common among girls. Urgent action is needed to improve the recognition of asthma in Vietnam.
Review
Physiology
Kubra F. Naqvi, Stuart B. Mazzone, Michael U. Shiloh
Summary: Coughing is a physiological process mediated by vagal sensory neurons in the airways and can be triggered by respiratory pathogens and inflammation. This process can be exploited by pathogens to spread diseases, as demonstrated by studies on cough-generated aerosols and disease transmission. This review provides an overview of the neurophysiology of cough, cough induction by pathogens and inflammation, and the transmission of diseases through coughing.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Respiratory System
Rachel E. Foong, Peter Franklin, Francesca Sanna, Graham L. Hall, Peter D. Sly, Eric B. Thorstensen, Dorota A. Doherty, Jeffrey A. Keelan, Roger J. Hart
Summary: This study investigated the effects of prenatal exposure to phthalates and bisphenol A (BPA) on asthma, allergy, and lung function outcomes from childhood to adulthood. The results showed that prenatal BPA exposure was associated with an increased likelihood of persistent asthma in males, while prenatal phthalate exposure was associated with an increased likelihood of adult asthma in males. However, lung function was not adversely affected by prenatal exposure to these chemicals.
Article
Nursing
M. Mamun Huda, Leonie K. Callaway, Greg Jackson, Yaqoot Fatima, Janet Cumming, Tuhin Biswas, Gonzalo R. Paz, Fran Boyle, Peter D. Sly, Abdullah Al Mamun
Summary: This study investigated the time trends, projections, and spatial distribution of low birthweight (LBW) in Australia from 2009 to 2030. The prevalence of LBW increased from 6.18% in 2009 to 6.64% in 2019. If the trend continues, the projected prevalence of LBW in Australia will reach 7.34% in 2030. The trends in LBW varied across different subpopulations, with stable rates among Indigenous mothers and increases among non-Indigenous mothers, disadvantaged mothers, and mothers who smoked during pregnancy.
BIRTH-ISSUES IN PERINATAL CARE
(2023)
Article
Medicine, Research & Experimental
Ayaho Yamamoto, Peter D. Sly, Keng Yih Chew, Lavrent Khachatryan, Nelufa Begum, Abrey J. Yeo, Luan D. Vu, Kirsty R. Short, Stephania A. Cormier, Emmanuelle Fantino
Summary: Epidemiological evidence shows a link between lower air quality and increased severity of COVID-19, but the mechanism is not yet understood. This study suggests that oxidative stress caused by air pollution could increase viral replication and inflammation in the nasal epithelium. The researchers found that exposure to an oxidant found in air pollution increased SARS-CoV-2 replication and inflammation-related gene expression, while antioxidant treatment reduced viral replication and inflammation. These findings indicate that oxidant damage to the respiratory epithelium may contribute to the association between poor air quality and increased COVID-19 severity.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Maryam Shojaei, Amir Shamshirian, James Monkman, Laura Grice, Minh Tran, Chin Wee Tan, Siok Min Teo, Gustavo Rodrigues Rossi, Timothy R. McCulloch, Marek Nalos, Maedeh Raei, Alireza Razavi, Roya Ghasemian, Mobina Gheibi, Fatemeh Roozbeh, Peter D. Sly, Kirsten M. Spann, Keng Yih Chew, Yanshan Zhu, Yao Xia, Timothy J. Wells, Alexandra Cristina Senegaglia, Carmen Lucia Kuniyoshi, Claudio Luciano Franck, Anna Flavia Ribeiro dos Santos, Lucia de Noronha, Sepideh Motamen, Reza Valadan, Omolbanin Amjadi, Rajan Gogna, Esha Madan, Reza Alizadeh-Navaei, Liliana Lamperti, Felipe Zuniga, Estefania Nova-Lamperti, Gonzalo Labarca, Ben Knippenberg, Velma Herwanto, Ya Wang, Amy Phu, Tracy Chew, Timothy Kwan, Karan Kim, Sally Teoh, Tiana M. Pelaia, Win Sen Kuan, Yvette Jee, Jon Iredell, Ken O'Byrne, John F. Fraser, Melissa J. Davis, Gabrielle T. Belz, Majid E. Warkiani, Carlos Salomon Gallo, Fernando Souza-Fonseca-Guimaraes, Quan Nguyen, Anthony Mclean, Arutha Kulasinghe, Kirsty R. Short, Benjamin Tang
Summary: This study found that the IFI27 gene is associated with COVID-19 infection and that its expression levels in the respiratory tract and blood are correlated with viral load and infection severity. IFI27 gene family biomarkers may supplement conventional diagnostic tools in future virus pandemics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Yuan Gao, Jakob Stokholm, Martin O'Hely, Anne-Louise Ponsonby, Mimi L. K. Tang, Sarath Ranganathan, Richard Saffery, Leonard C. Harrison, Fiona Collier, Lawrence Gray, David Burgner, John Molloy, Peter D. Sly, Susanne Brix, Hanne Frokiaer, Peter Vuillermin
Summary: Having older siblings can decrease the risk of IgE-mediated food allergy by accelerating the maturation of the infant gut microbiota.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Pedro Trevizan-Bau, Stuart B. Mazzone
Summary: This article reviews the recent literature on neuroimmune interactions in airway inflammation and discusses the considerations for the clinical translation of these discoveries to improve the management of patients with airway disease.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Immunology
Md Moniruzzaman, M. Arifur Rahman, Ran Wang, Kuan Yau Wong, Alice C. -H. Chen, Alexandra Mueller, Steven Taylor, Alexa Harding, Thishan Illankoon, Percival Wiid, Haressh Sajiir, Veronika Schreiber, Lucy D. Burr, Michael A. Mcguckin, Simon Phipps, Sumaira Z. Hasnain
Summary: This study reveals an important role of IL-22 in regulating the expression of epithelial cell-specific MHC II. IL-22 suppresses MHC II expression by modulating endoplasmic reticulum stress. This finding is significant for understanding the homeostatic regulation of epithelial cell MHC II.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Virology
Yury A. Bochkov, Mark Devries, Kaitlin Tetreault, Ronald Gangnon, Sujin Lee, Leonard B. Bacharier, William W. Busse, Carlos A. Camargo, Timothy Choi, Robyn Cohen, Ramyani De, Gregory P. DeMuri, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Peter N. Le Souef, Andrew H. Liu, David T. Mauger, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Robert F. Lemanske, Daniel J. Jackson, James E. Gern
Summary: This study examined cross-neutralization reactions and antibody duration of rhinovirus type A (RV-A) and type C (RV-C). The results showed limited cross-neutralization reactions between the two types, which are limited to genetically similar strains. However, the duration of antibody response during childhood is similar for both types.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cindy Pham, Sarah Thomson, Sung-Tong Chin, Peter Vuillermin, Martin O'Hely, David Burgner, Samuel Tanner, Richard Saffery, Toby Mansell, Sze Bong, Elaine Holmes, Peter D. Sly, Nicola Gray, Anne-Louise Ponsonby, Barwon Infant Study Invest Grp
Summary: Childhood mental disorders are becoming increasingly common, and higher maternal oxidative stress during pregnancy is linked to these disorders. Social and prenatal environmental factors contribute to maternal oxidative stress and childhood mental disorders. Future studies are needed to further understand the role of early-life oxidant damage in childhood mental disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Bodie Curren, Tufael Ahmed, Daniel R. Howard, Md. Ashik Ullah, Ismail Sebina, Ridwan B. Rashid, Md. Al Amin Sikder, Patricia Namubiru, Alec Bissell, Sylvia Ngo, David J. Jackson, Marie Toussaint, Michael R. Edwards, Sebastian L. Johnston, Henry J. McSorley, Simon Phipps
Summary: Rhinvovirus-induced neutrophils and IL-33 play important roles in acute asthma exacerbations, and blocking IL-33 release can alleviate the severity of the exacerbation by attenuating neutrophil recruitment and the generation of NETs.
MUCOSAL IMMUNOLOGY
(2023)
Article
Pediatrics
K. M. Shahunja, Peter D. Sly, Abdullah Mamun
Summary: This study aimed to investigate the changing patterns of important psychosocial environmental factors and their associations with asthma symptom trajectories among children in Australia. The study identified the associations between factors such as maternal depression, parents' financial hardship, and parents' stressful life events with persistent high asthma symptom trajectories in children.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Michael Cousins, Kylie Hart, Bence L. Radics, A. John Henderson, Zoltan Hantos, Peter D. Sly, Sailesh Kotecha
Summary: Although the mechanisms underlying lung dysfunction after preterm birth are not well understood, studying the phenotypes of prematurity-associated lung disease can help to elucidate the underlying mechanisms. This study used oscillometry to assess lung function in preterm-born children and term controls, and found that preterm-born children with obstructive airway disease had the greatest impairments in oscillometry, which were significantly improved after postexercise bronchodilator administration. These findings suggest that oscillometry could potentially be used as a tool to identify preterm-born children with lung disease and institute appropriate treatment.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Mari D. Takashima, Keith Grimwood, Peter D. Sly, Stephen B. Lambert, Robert S. Ware
Summary: This study evaluated the interaction between rhinovirus and potentially pathogenic bacteria in early infancy and their association with wheezing and asthma. The results showed that rhinovirus infection increased the risk of wheezing before age 2 years, while Haemophilus influenzae infection increased the odds of asthma at age 5-7 years. Microbes may have an etiologic role in wheezing and asthma.
PEDIATRIC PULMONOLOGY
(2023)