Article
Biochemistry & Molecular Biology
Yi Zhang, Christina G. Towers, Upendra K. Singh, Jiuyang Liu, Maria Hakansson, Derek T. Logan, Oreola Donini, Tatiana G. Kutateladze
Summary: This study describes the structural basis and biological consequences of the interaction between p62 and the next generation of IDR dusquetide. The findings show that dusquetide forms a complex with p62, modulates the p62-RIP1 complex, enhances p38 phosphorylation, and increases CEBP/B expression without activating autophagy. These findings provide insights into the molecular details of IDR action and may have implications for the development of new strategies to target p62 pharmacologically.
Review
Multidisciplinary Sciences
Toufic Mayassi, Luis B. Barreiro, Jamie Rossjohn, Bana Jabri
Summary: This review paper redefines unconventional T cell subsets based on their ligand recognition, receptor expression, structural features, and acquisition of functions. Unconventional T cells follow specific selection rules and can recognize self or evolutionarily conserved microbial antigens, playing a critical role in tissue homeostasis and immune function.
Review
Immunology
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock
Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi, Rossana Signorelli, Harrys K. C. Jacob, John George, Preeti Sahay, Ejas P. Bava, Rajinder Dawra, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja
Summary: The absence of Hsp70 in the tumor microenvironment inhibits tumor growth through immune cells, and Hsp70(-/-) dendritic cells inhibit tumor growth by enhancing the immune response.
Article
Gastroenterology & Hepatology
Qin Yu, Rachel C. Newsome, Mark Beveridge, Maria C. Hernandez, Raad Z. Gharaibeh, Christian Jobin, Ryan M. Thomas
Summary: This study demonstrates that the gut microbiota can promote the progression of PDAC tumors by modulating the activity and intra-tumoral infiltration of NK cells.
Article
Oncology
Chen Qian, Deluo Wu, Jianwei Du
Summary: This study comprehensively elucidated the RIPK3 profile in sarcoma, including its expression, modulation of gene expression and signaling pathways, immune checkpoint therapy, and immune cell infiltration. Higher RIPK3 expression was associated with improved survival, increased expression of the immune checkpoint gene HAVCR2, and an improved response to immune blockade therapy. These findings suggest that RIPK3 could be a potential therapeutic target for sarcoma.
Review
Immunology
Aleksandra J. Ozga, Melvyn T. Chow, Andrew D. Luster
Summary: Chemokines play a critical role in directing immune cell migration and are involved in shaping the tumor-promoting microenvironment.
Article
Cell Biology
Gangipangi Vijayakumar, Uppalapati S. Swetha, Selvaraju Sudhagar
Summary: This study found that tamoxifen supports breast cancer growth by modulating mitochondrial dynamics. Under nutrition-deprived conditions, tamoxifen enhances mitochondrial fusion by suppressing Drp1 phosphorylation and upregulating Mfn1 levels. Additionally, tamoxifen also regulates the fusion morphology of mitochondria through the activation of AMPK and JNK signaling pathways.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Hongda Jiang, Shenshen Wang
Summary: Cells can use mechanical work to drive their own evolution, similar to the adaptive immune system. Immune B cells extract antigens from other cells' surfaces using cytoskeletal forces. This force usage can accelerate adaptation but may also cause cell population extinction, resulting in an optimal range of pulling strength. The extraction of environmental signals through active force can make biological systems more evolvable at a moderate energy cost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Greg M. Allen, Nicholas W. Frankel, Nishith R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim
Summary: In this study, we engineered circuits in CAR T cells to locally induce production of the cytokine IL-2 using tumor-specific synNotch receptors. These circuits enhance CAR T cell infiltration and clearance of immunosuppressive tumors, without causing systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and TCR- or CAR-independent manner, bypassing key tumor suppression mechanisms.
Article
Multidisciplinary Sciences
Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Goto, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe, Aki Hori, Yoshiki Momiuchi, Hiroki Ishikawa, Hiroaki Suzuki, Kumiko Nabe, Takeshi Takagaki, Masataka Fukuzaki, Li-Li Tong, Sinya Yamada, Yoshiteru Oshima, Toshiro Aigaki, Julian A. T. Dow, Shireen-Anne Davies, Shoichiro Kurata
Summary: The study demonstrates that the NF-kappa B signaling pathway in Drosophila is activated through a pathway parallel to the Toll receptor, involving the receptor-type guanylate cyclase Gyc76C. This pathway produces cGMP and modulates NF-kappa B signaling to combat bacterial infections. Furthermore, the modulation of NF-kappa B activation by the cGMP signaling pathway is evolutionarily conserved in both fruit flies and human cells.
Article
Chemistry, Multidisciplinary
Duo Wang, Mengqi Zhang, Yan Zhang, Guanhua Qiu, Jie Chen, Xiaoqi Zhu, Cunqing Kong, Xiuxin Lu, Xiayi Liang, Lixia Duan, Chao Fang, Junjie Liu, Kun Zhang, Tao Luo
Summary: By designing a sonoimmunity-engineered nanoplatform, CAR-T and immune checkpoint blockade (ICB) immunotherapies against solid tumors can achieve significant results by eliminating immunosuppression and infiltration barriers using reactive oxygen species and nitric oxide generated during sonodynamic process.
Article
Biochemistry & Molecular Biology
Tailin He, Bo Zhou, Guohuan Sun, Qinnan Yan, Sixiong Lin, Guixing Ma, Qing Yao, Xiaohao Wu, Yiming Zhong, Donghao Gan, Shaochuan Huo, Wenfei Jin, Di Chen, Xiaochun Bai, Tao Cheng, Huiling Cao, Guozhi Xiao
Summary: The novel Pinch-Cxcl12-Mbl2 signaling pathway promotes the interactions between bone and liver to modulate immunity and hematopoiesis, which may provide a useful therapeutic target for immune and infectious diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Multidisciplinary
Shin-Tai Chen, Jiahn-Haur Liao, Kai-Fa Huang, I-Ming Lee, Wei-Ting Wong, Shih-Hsiung Wu, Kuo-Feng Hua
Summary: The study demonstrated the interaction between CGL and the TLR4/MD2 complex in a protein-TLR4 binding model, suggesting potential therapeutic targeting of TLR4. CGL was shown to significantly suppress immune responses induced by lipopolysaccharide.
CHEMICAL COMMUNICATIONS
(2021)
Article
Cell Biology
Annika Traa, Sonja K. Soo, Abdelrahman AlOkda, Bokang Ko, Christian E. Rocheleau, Jeremy M. Van Raamsdonk
Summary: The mutation of tbc-2 gene affects the nuclear localization of DAF-16 and its resistance to stress, leading to a decrease in lifespan. This indicates the importance of endosomal trafficking for the proper nuclear localization of DAF-16 during stress and suggests that perturbation of normal endosomal trafficking is sufficient to decrease both stress resistance and lifespan.