期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 34, 期 1, 页码 155-160出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201307049Z
关键词
camptothecin; amino acid-conjugates; cytotoxic activities
资金
- National Natural Science Foundation of China [30870730]
A series of amino acid-conjugates of 10-hydroxycamptothecin and 9-nitro-10-hydroxycamptothecin were synthesized by means of a two-carbon side chain from 10-hydroxycamptothecin. The cytotoxic activities of all the synthetic compounds on KB, HepG2 and C26 in vitro were evaluated by CCK-8 assay. The results revealed that part of the conjugates exhibit potent anti-proliferative activities against selected tumor cell lines. Among them, the amino acid-conjugates of 10-hydroxycamptothecin show more potent activities than those of 9-nitro-10-hydroxycamptothecin in vitro as antitumor agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据