UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse

(2015) Bo-Ra Na et al.   JOURNAL OF CELL BIOLOGY

Interactions with Actin Monomers, Actin Filaments, and Arp2/3 Complex Define the Roles of WASP Family Proteins and Cortactin in Coordinately Regulating Branched Actin Networks

(2014) Luke A. Helgeson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency

(2014) Frank Cichocki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear Role of WASp in Gene Transcription Is Uncoupled from Its ARP2/3-Dependent Cytoplasmic Role in Actin Polymerization

(2014) S. Sadhukhan et al.   JOURNAL OF IMMUNOLOGY

Binding of the WASP/N-WASP-Interacting Protein WIP to Actin Regulates Focal Adhesion Assembly and Adhesion

(2014) N. Ramesh et al.   MOLECULAR AND CELLULAR BIOLOGY

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

(2014) E. M. Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

(2013) A. Cohnen et al.   BLOOD

WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin Polymerization

(2013) Sara K. Donnelly et al.   CURRENT BIOLOGY

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D

(2011) M. Meeths et al.   BLOOD

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

(2011) K. B. Sanborn et al.   BLOOD

IQGAP1 involvement in MTOC and granule polarization in NK-cell cytotoxicity

(2011) Namita Kanwar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans

(2011) W. Ni et al.   JOURNAL OF CELL SCIENCE

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

(2011) E. Sieni et al.   JOURNAL OF MEDICAL GENETICS

Differential Turnover of Myosin Chaperone UNC-45A Isoforms Increases in Metastatic Human Breast Cancer

(2011) Wei Guo et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function

(2011) Edo D. Elstak et al.   PEDIATRIC BLOOD & CANCER

UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region

(2010) H. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Myosin IIA Associates with NK Cell Lytic Granules to Enable Their Interaction with F-Actin and Function at the Immunological Synapse

(2009) K. B. Sanborn et al.   JOURNAL OF IMMUNOLOGY