Article
Immunology
Su Jeong Lee, Bo Ruem Yoon, Hee Young Kim, Su-Jin Yoo, Seong Wook Kang, Won-Woo Lee
Summary: The study demonstrates that activated platelets induce CD16 expression on classical CD14(+)CD16(-) monocytes through soluble factors, contributing to antibody-dependent cellular phagocytosis (ADCP). CD14(+)CD16(-) monocytes treated with activated platelets preferentially differentiate into M2 macrophages, and elevated levels of the activated platelet marker sCD62P are found in plasma of rheumatoid arthritis patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Raghunathan Jagannathan, Thodur Madapusi Balaji, Saranya Varadarajan, B. Bhuvaneswari, C. J. Venkatakrishnan, S. Lakshmi Priya, Swaminathan Rajendran, Mohammed E. Sayed, Maryam H. Mugri, Shankargouda Patil
Summary: Periodontitis has been suggested as a significant risk factor for adverse pregnancy outcomes, with elevated levels of periodontal pathogenic bacteria and proinflammatory cytokines believed to contribute to preterm delivery through placental infection and premature rupture of the amniotic membrane. The role of CD14+CD16+ monocytes in this process has not been widely researched, but potential mechanistic links between periodontitis and adverse pregnancy outcomes are being explored.
MEDICAL HYPOTHESES
(2021)
Article
Immunology
Qinglei Yin, Dalong Song, Juan Chen, Guang Ning, Weiqing Wang, Shu Wang
Summary: CD14++CD16+ monocytes play a critical role in the pathogenesis of Graves' disease and promote the generation of potentially pathogenic Th responses in GD.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Abelardo Caballero, Teresa Vazquez-Sanchez, Pedro Ruiz-Esteban, Myriam Leon, Juana Alonso-Titos, Veronica Lopez, Eugenia Sola, Elena Gutierrez, Mercedes Cabello, Cristina Casas-Gonzalez, Rafael Pozo-Alvarez, Juan Delgado-Burgos, Domingo Hernandez
Summary: The study revealed that CD14++CD16+ monocytes in low-immunological-risk kidney transplant recipients were significantly lower in cases of subclinical borderline lesions, potentially serving as an early indicator for rejection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Karin Anne Lydia Mueller, Carolin Langnau, Manina Guenter, Simone Poeschel, Sarah Gekeler, Alvaro Petersen-Uribe, Klaus-Peter Kreisselmeier, Karin Klingel, Hans Boesmueller, Bo Li, Philippa Jaeger, Tatsiana Castor, Dominik Rath, Meinrad Paul Gawaz, Stella E. Autenrieth
Summary: Decreased numbers of CD14(dim)CD16(+) monocytes are associated with an increased risk of rapidly progressive respiratory failure in patients with both coronary artery disease (CAD) and SARS-CoV-2 infection. Intensified risk assessments involving monocyte subtypes and phenotypes may help identify patients at higher risk for respiratory failure.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, General & Internal
Nik Syazana Izyan Saffery, Krishnamurithy Genasan, Chee Ken Chan, Khairul Anwar Ayob, Seow Hui Teo, Mohamed Zubair Mohamed Al-Fayyadh, Iekhsan Othman, Syafiq Asnawi Zainal Abidin, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul
Summary: This study found that osteoarthritis synovium has a specific protein profile that can cause migration, activation, and functional commitment of monocytes. These findings may have important implications for the treatment of osteoarthritis.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kirsten Glaser, David Kern, Christian P. Speer, Nicolas Schlegel, Michael Schwab, Ulrich H. Thome, Christoph Haertel, Clyde J. Wright
Summary: Developmentally regulated features of innate immunity in preterm and term infants may increase the risk of infection and inflammation-related morbidity. This study investigated the cytokine expression and monocyte subsets in cord blood monocytes of preterm and term infants compared to adult controls. The results showed robust pro-inflammatory but attenuated anti-inflammatory responses, as well as imbalanced cytokine ratios, in cord blood monocytes of preterm and term infants. Intermediate monocytes, known for their pro-inflammatory features, may contribute to this inflammatory state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
He Zhang, Shi-lei Wang, Tao Sun, Jia Liu, Ping Li, Jing-ci Yang, Fang Gao
Summary: Collateral formation in patients with acute myocardial infarction (AMI) is associated with CD14++CD16+ monocytes and vascular endothelial growth factors (VEGFs). In a study of 49 AMI patients, it was found that patients with early collateral formation had significantly higher levels of CD14++CD16+ monocytes and serum VEGFs compared to patients with late collateral formation. Additionally, serum VEGF levels were positively correlated with CD14++CD16+ monocytes. These results suggest that regulating CD14++CD16+ monocytes and VEGFs is crucial for collateral formation and AMI healing.
Article
Immunology
Yunyun Xu, Xu Hou, Honglin Guo, Zhenyu Yao, Xiude Fan, Chao Xu, Guimei Li, Yanzhou Wang, Yan Sun, Ling Gao, Yongfeng Song, Jiajun Zhao
Summary: Patients with Prader-Willi syndrome (PWS) show hyper-inflammatory state in their peripheral immune cells, characterized by increased CD16(+) monocytes. These monocytes transmit chemokine and cytokine signaling to drive inflammatory process in other cell types. This study provides insights into the characteristics of peripheral immune cells in PWS at the single cell level and suggests potential targets for immunotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Dimitrios Vitsios, Ryan S. Dhindsa, Dorota Matelska, Jonathan Mitchell, Xuequing Zou, Joshua Armenia, Fengyuan Hu, Quanli Wang, Ben Sidders, Andrew R. Harper, Slave Petrovski
Summary: Large reference datasets have allowed us to determine germline genetic variation intolerance in genes and genic subregions. We introduced a new metric, OncMTR, which identified genic subregions enriched with cancer-driving mutations that are depleted of germline variation. OncMTR significantly predicted driver mutations in hematologic malignancies and improved genetic signals for these diseases.
Article
Neurosciences
Yuqin Men, Haruki Higashimori, Kathryn Reynolds, Leona Tu, Rachel Jarvis, Yongjie Yang
Summary: This study investigates the role of FMRP in astroglial processes and reveals that the loss of FMRP affects mRNA localization and expression. These findings provide new insights into the interactions and signaling mechanisms between astroglial processes and synapses.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Di Cui, Alexandra Franz, Sophie A. Fillon, Linda Jannetti, Timo Isambert, Katrin Fundel-Clemens, Heinrich J. Huber, Coralie Viollet, Alexander Ghanem, Akira Niwa, Bernd Weigle, Stefan Pflanz
Summary: This study presents a fully optimized differentiation protocol of hiPSC-derived myeloid lineage cells and highlights their applications in research, drug screening, and cell therapies in functional verification.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Sergio M. de Almeida, Miriam Perlingeiro Beltrame, Bin Tang, Indianara Rotta, Ian Abramson, Florin Vaida, Rachel Schrier, Ronald J. Ellis
Summary: This study investigated the proportion differences of monocytes in cerebrospinal fluid (CSF) and peripheral blood (PB) between individuals with HIV-1C and HIV-1B subtypes, and found a higher proportion of CD14(++)CD16(+) monocytes in the CSF of HIV-1C patients. Furthermore, despite viral suppression, the total monocyte proportion in PB increased in people with HIV due to the increase in CD14(++)CD16(+) and CD14(low)CD16(+) monocytes.
JOURNAL OF NEUROVIROLOGY
(2023)
Article
Cell Biology
Y. Lin, D. F. Postma, L. S. Steeneken, L. S. Melo dos Santos, J. L. Kirkland, J. M. Espindola-Netto, T. Tchkonia, M. Borghesan, H. R. Bouma, M. Demaria
Summary: This study found that senescence-associated markers can predict SARS-CoV-2 infection by measuring them in whole blood, plasma, and peripheral blood mononuclear cells of COVID-19 patients and patients without an infection. Single-cell RNA sequencing data showed that a senescence signature is particularly enriched in monocytes of COVID-19 patients, partially correlating with disease severity.
Article
Medicine, General & Internal
Anila Duni, Georgios Vartholomatos, Olga Balafa, Margarita Ikonomou, Paraskevi Tseke, Lampros Lakkas, Karolos Paulos Rapsomanikis, Athanasios Kitsos, Ioanna Theodorou, Charalambos Pappas, Katerina K. Naka, Michael Mitsis, Evangelia Dounousi
Summary: The altered expression of immune cells in end-stage kidney disease impacts inflammation and immunity. This study focused on investigating specific immune cell subsets in PD patients with established cardiovascular disease. The results showed that PD patients had lower lymphocytes and B cells but higher CD14++CD16+ monocytes compared to healthy controls, with a higher risk of CAD associated with elevated NK cells levels.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Ophthalmology
Marcela Bohn, Luciano Bravo-Ljubetic, Richard W. J. Lee, Harry Petrushkin
Summary: This report presents two cases of severe uveitis associated with ibrutinib use in patients with chronic lymphocytic leukaemia. Both patients experienced significant improvement in ocular inflammation after discontinuing the medication, suggesting a causative link. Ibrutinib's impact on Th1-based immune responses and antiplatelet effect may contribute to the development of uveitis symptoms.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Letter
Hematology
Madeleine L. Stimpson, Julia S. Wolf, Emily L. Williams, Philippa J. P. Lait, Lauren P. Schewitz-Bowers, Rosemary Greenwood, Julie Pell, Ian Thomas, Richard W. J. Lee, Charlotte A. Bradbury
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Richard Parker, Joaquin Cabezas, Jose Altamirano, Juan Pablo Arab, Meritxell Ventura-Cots, Ashish Sinha, Ashwin Dhanda, Marco Arrese, C. Anne McCune, Ian A. Rowe, Bernd Schnabl, Phillipe Mathurin, Debbie Shawcross, Juan G. Abraldes, Michael R. Lucey, Guadalupe Garcia-Tsao, Elizabeth Verna, Robert S. Brown, Francisco Bosques-Padilla, Victor Vargas, Alexandre Louvet, Andrew P. Holt, Ramon Bataller
Summary: By analyzing the trajectory of serum bilirubin concentration over the course of hospital admissions, we can predict spontaneous survival and the need for treatment in patients with alcoholic hepatitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Keith Pohl, Prebashan Moodley, Ashwin Dhanda
Summary: Supplementation of short chain fatty acids (SCFAs) has shown potential as a therapy for liver disease by improving gut barrier function. Studies have demonstrated that SCFA supplementation can reduce liver injury and intestinal permeability, leading to improved liver disease models. However, the outcome measures used in the existing research may not be practical for human studies.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Substance Abuse
Jane Horrell, Lynne Callaghan, Ashwin Dhanda
Summary: Ongoing alcohol use among patients with alcohol-related liver disease (ArLD) is influenced by various factors, including mental health diagnoses associated with alcohol dependence severity and social and environmental determinants. Poor communication, lack of symptom recognition, and perceived loss of control over their condition are common barriers to treatment for ArLD patients. Further studies are needed to assess psychosocial factors, explore patient journeys, and identify factors associated with relapse in order to improve engagement with treatment and long-term outcomes.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Ashwin Dhanda, Keith Bodger, Steve Hood, Clive Henn, Michael Allison, Chioma Amasiatu, Robyn Burton, Matthew Cramp, Ewan Forrest, Meetal Khetani, Alastair MacGilchrist, Steven Masson, Richard Parker, Nick Sheron, Ken Simpson, Nikhil Vergis, Martin White
Summary: The Liverpool ArLD Algorithm (LAA) can be successfully applied to both national and local datasets, providing a more accurate identification of alcohol-related liver disease admissions. The algorithm has revealed the true extent of ArLD admissions and the COVID-19 pandemic has exacerbated the long-term increase in ArLD admissions and mortality.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Keith Bodger, Ashwin Dhanda
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, General & Internal
Michael E. D. Allison, Julia Verne, William Bernal, Michelle Clayton, Sam Cox, Ashwin Dhanda, John F. Dillon, James Ferguson, Graham Foster, Ian Gilmore, Vanessa Hebditch, Rebecca Jones, Steven Masson, Beverley Oates, Paul Richardson, Julia Sinclair, Julia Wendon, David Wood
Article
Endocrinology & Metabolism
Peter Taylor, Rathie Rajendram, Stephanie Hanna, Victoria Wilson, Julie Pell, Chunhei Li, Anne Cook, Rao Gattamaneni, Nicholas Plowman, Sue Jackson, Robert Hills, Robert French, Jimmy M. Uddin, Richard W. J. Lee, Colin M. Dayan
Summary: Graves orbitopathy is a disabling and disfiguring disease. The long-term outcomes of a clinical trial showed that after three years, there was no additional benefit for patients who received azathioprine or radiotherapy. Although clinical activity score, ophthalmopathy index, and total eye score improved over three years, quality of life remained poor and a high percentage of patients required surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Paula Boeira, Huey Tan, Euan Yates, Ashwin Dhanda
Summary: This study tested the QuantiFERON Monitor (QFM) as a measure of immune function in predicting clinical outcomes in patients with severe alcoholic hepatitis. The findings showed that interferon (IFN)-gamma release measured by standard QFM accurately predicted early mortality at 28 and 90 days in these patients. The measurement of IFN-gamma, IL-10, and IL-23 release also showed potential as a biomarker for subsequent infection.
Article
Hematology
Madeleine L. Stimpson, Julia Wolf, Bruno Charbit, Emily L. Williams, Philippa J. P. Lait, Lauren P. Schewitz-Bowers, Richard W. J. Lee, Charlotte A. Bradbury
Summary: Regulatory B (Breg) cells play an important role in the pathogenesis of immune thrombocytopenia (ITP). The numbers of Bregs are significantly reduced in ITP patients treated with immunosuppression, and glucocorticoid treatment impairs Breg interleukin-10 production via an indirect T-cell-mediated mechanism.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Ophthalmology
Emilia Bober, Kristina Frain, Majid Fotuhi, Jonathan Virgo, Edward Hindle, Jianfei Ma, Joshua Luis, Peter Addison, Narciss Okhravi, William Tucker, Mark Westcott, Carlos Pavesio, Richard Lee, Ian Yeung
Letter
Gastroenterology & Hepatology
Keith Pohl, Ashwin Dhanda
FRONTLINE GASTROENTEROLOGY
(2023)
Meeting Abstract
Surgery
T. Woo, C. Li, S. Ganesananthan, R. Rajendram, J. Uddin, R. Lee, C. Dayan, P. Taylor
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Ashwin D. Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C. Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, E. Siobhan Creanor
Summary: This article presents a pilot trial conducted in the UK on a psychological therapy (FIT) for patients with alcohol-related liver disease (ArLD). The trial aims to test the feasibility of training alcohol liaison nurses to deliver FIT therapy and to conduct a randomized trial of FIT and treatment as usual (TAU) versus TAU alone in ArLD patients. The results of the trial will help finalize the design of a definitive randomized controlled trial to assess the effectiveness and cost-effectiveness of FIT.