Review
Immunology
Julia Lichtnekert, Hans-Joachim Anders, Maciej Lech
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus, and its treatment still faces many challenges. The progression of chronic kidney disease poses risks to patients, while the development of biomarkers provides hope for personalized treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Transplantation
Hans-Joachim Anders, Jerome Loutan, Annette Bruchfeld, Gema M. Fernandez-Juarez, Juergen Floege, Dimitrios Goumenos, Kultigin Turkmen, Cees van Kooten, Eleni Frangou, Kate Stevens, Andreas Kronbichler, Marten Segelmark, Vladimir Tesar
Summary: This article presents the updated guidelines on the management of lupus nephritis (LN) released by the European League for Rheumatism (EULAR) and other organizations. The article compares the differences between these guidelines and highlights their significance in LN management.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Minghao Gong, Seung-Chu Choi, Yuk Pheel Park, Xueyang Zou, Ahmed S. Elshikha, Valerie A. Gerriets, Jeffrey C. Rathmell, Mansour Mohamazadeh, Laurence Morel
Summary: The expansion of follicular helper T (Tfh) cells in lupus can be reversed by inhibiting glycolysis or glutaminolysis. In a mouse model of lupus, gene expression and metabolome analysis revealed enhanced signaling and effector programs in Tfh cells. Metabolically, Tfh cells showed defective mitochondrial functions and specific anabolic programs including enhanced glutamate metabolism. Targeting these specific metabolic programs can potentially limit the expansion of pathogenic Tfh cells in lupus.
Article
Toxicology
Victor Yuji Yariwake, Janaina Iannicelli Torres, Amandda Rakell Peixoto dos Santos, Sarah Cristina Ferreira Freitas, Katia De Angelis, Sylvia Costa Lima Farhat, Niels Olsen Saraiva Camara, Mariana Matera Veras
Summary: This study found that exposure to fine particulate matter air pollution exacerbates some SLE manifestations in lupus-prone mice, highlighting the need to reduce air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Immunology
Antoine N. Kraemer, Anna-Lena Schaefer, Dalina T. L. Sprenger, Bettina Sehnert, Johanna P. Williams, Aileen Luo, Laura Riechert, Qusai Al-Kayyal, Helene Dumortier, Jean-Daniel Fauny, Zoltan Winter, Kathrin Heim, Maike Hofmann, Martin Herrmann, Guido Heine, Reinhard E. Voll, Nina Chevalier
Summary: Vitamin D deficiency is highly prevalent worldwide and is associated with the development of systemic lupus erythematosus (SLE) and other immune-mediated diseases. In this study, low vitamin D intake was found to accelerate lupus progression in lupus-prone mice, possibly by affecting the regulatory phenotype of lymphocytes. Correcting vitamin D deficiency can not only prevent osteoporosis but also serve as an important component in the prevention and treatment of lupus and other immune-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Tejon, Nicolas Valdivieso, Felipe Flores-Santibanez, Veronica Barra-Valdebenito, Victor Martinez, Mario Rosemblatt, Daniela Sauma, Maria Rosa Bono
Summary: This study investigated the phenotype and function of peritoneal macrophages in a murine model of SLE. The results showed that macrophages from diseased mice exhibited altered phenotype and function, shifting towards a pro-inflammatory state. Additionally, there was an accumulation of B1a cells in the peritoneal cavity. These findings contribute to a better understanding of SLE and may aid in the development of novel therapies.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Immunology
Stefan Rosenberger, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Gabriela Riemekasten, Jens Y. Humrich
Summary: Treg cells play a regulatory role in controlling the activation and expansion of autoreactive CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Linyu Geng, Jian Zhao, Yun Deng, Ivan Molano, Xue Xu, Lingxiao Xu, Phillip Ruiz, Quanzhen Li, Xuebing Feng, Miaojia Zhang, Wenfeng Tan, Diane L. Kamen, Sang-Cheol Bae, Gary S. Gilkeson, Lingyun Sun, Betty P. Tsao
Summary: The NCF1-H90 variant contributes to the development of systemic lupus erythematosus by reducing macrophage efferocytosis, enhancing Tfh2 responses, promoting autoantibody production, and causing kidney damage in both mice and patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Summary: Repeated intranasal instillation of lupus-prone mice with crystalline silica induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, which can be suppressed by dietary supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA). The inflammatory proteins induced by crystalline silica in bronchoalveolar alveolar lavage fluid (BALF) were time-dependently increased, but were attenuated by DHA supplementation. Analysis revealed that the inflammatory proteome in BALF correlated positively with gene expression, ectopic lymphoid tissue neogenesis, and autoantibody induction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Maria Prendecki, Stephen P. McAdoo, Tabitha Turner-Stokes, Ana Garcia-Diaz, Isabel Orriss, Kevin J. Woollard, Jacques Behmoaras, H. Terence Cook, Robert Unwin, Charles D. Pusey, Timothy J. Aitman, Frederick W. K. Tam
Summary: P2RX7 is not involved in inflammation and autoimmunity in glomerulonephritis, and there is an alternative inflammasome pathway for IL-1β production in rat dendritic cells, independent of P2RX7.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jordi Guiteras, Elena Crespo, Pere Fontova, Nuria Bolanos, Montse Goma, Esther Castano, Oriol Bestard, Josep M. Grinyo, Joan Torras
Summary: The study discovered a human fusion protein called Hybri, which effectively improves lupus nephritis by blocking the costimulatory pathway and exacerbating the coinhibitory pathway. This treatment method achieved good results in both lupus-prone models and severe lupus nephritis models, and also affected inflammatory-related cytokines and kidney gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Emma J. Keller, Nina Dvorina, Trine N. Jorgensen
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by dysregulated T and B lymphocytes. Type I interferons (IFN-I) play important roles in SLE, affecting B cell differentiation, autoantibody production, and development of glomerulonephritis. However, the specific effects of IFN-I on T cells and the role of different T cell subsets in SLE are not well understood. This study used a mouse model of lupus to investigate the role of T cell-specific IFN-I stimulation. The results suggest that IFN-I specifically affects CD8+ T cells and may contribute to both pathogenic and immunosuppressive responses in lupus-like autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Albert Jang, Robert Sharp, Jeffrey M. Wang, Yin Feng, Jin Wang, Min Chen
Summary: The production of autoantibodies by autoreactive B cells is crucial in the pathogenesis of lupus. Autophagy plays a key role in maintaining autoreactive memory B cells, and its deficiency leads to a decrease in these cells and a reduction in autoantibody production. Targeting autophagy may be a potential strategy to suppress autoreactive memory B cells and ameliorate humoral autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Gali Aljadeff, Asaf Shemer, Itai Katz, Luis Eduardo C. Andrade, Boris Gilburd, Gilad Halpert, Michael Mahler, Miri Blank, Howard Amital, Yehuda Shoenfeld
Summary: In this study, it was found that anti-DFS70 antibodies attenuated the progression of glomerulonephritis and prolonged the survival time in mice. 80% of mice injected with anti-DFS70 did not show severe glomerulonephritis by histology. This research may propose a new therapeutic approach for lupus patients.
Article
Rheumatology
Alvaro Gomez, Sandra Jagerback, Christopher Sjowall, Ioannis Parodis
Summary: This study aimed to investigate the effect of antimalarial agents (AMA) and different doses and pharmaceutical forms of belimumab on preventing renal flares in SLE patients. The results showed that intravenous belimumab at doses of 10 mg/kg and 1 mg/kg significantly reduced the risk of renal flares, while subcutaneous belimumab at a dose of 200 mg did not show significant association. The use of AMA also resulted in a lower hazard of renal flares, and the combination of belimumab and AMA enhanced the protective effect.