Review
Medicine, Research & Experimental
Zhangyang Bi, Wei Zhang, Xiaoyan Yan
Summary: ICA and ICT, the main active ingredients of Epimedium, have anti-inflammatory and immunomodulatory effects and hold promising clinical applications in the treatment of various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ana Paco, Teresa Bras, Jacqueline O. Santos, Paula Sampaio, Andreia C. Gomes, Maria F. Duarte
Summary: This review summarizes the current knowledge regarding the therapeutic potential of sesquiterpene lactones in immune and inflammatory activities, discussing the action mechanisms, bioaccessibility, and molecular structure-activity relationships in different cellular models and in vivo studies. Additionally, the impact of plant metabolic engineering and extraction methodologies on biological activity enhancement is presented.
Article
Integrative & Complementary Medicine
Hui Chen, Wei Feng, Ye Lu, Yi Yang, Zhong-hai Xin, Man Li, Li Xin, Ying-di Gong
Summary: Chinese medicine, represented by the formula Jiawei Yupingfeng (JWYPF), has shown potential therapeutic effects on allergic rhinitis (AR) by adjusting the balance of T helper 1 and T helper 2 cells. This study explored the mechanisms underlying the effects of JWYPF on ovalbumin-induced AR in mice, demonstrating significant reductions in allergic inflammation markers and symptom scores compared to the control group.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Pharmacology & Pharmacy
Qian Li, Ciqiu Tian, Xiangjie Liu, Dinglin Li, Hao Liu
Summary: Osteoporosis is a metabolic bone disorder characterized by decreased bone mass and compromised microarchitecture, which leads to bone deterioration and increased fracture risk. The main causes of osteoporosis are increased osteoclast activity or quantity and decreased osteoblast viability. Various mechanisms, including estrogen shortage, aging, chemical agents, and decreased mechanical loads, have been linked to osteoporosis, and recently inflammation and oxidative stress have also been found to play a role. Currently, bisphosphonates and selective estrogen receptor modulators (SERMs) are the primary medications used to treat osteoporosis, but they do not target inflammation and oxidative stress-induced osteoporosis and have limitations due to side effects. Traditional Chinese medicine (TCM) has a long history in osteoporosis treatment and is considered safe. This review focuses on botanical drugs that have an effect on inflammation and oxidative stress-induced osteoporosis, discussing the pharmacologically active ingredients and pathways, aiming to discover more safe and effective drugs for osteoporosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Rheumatology
Rabaa Takala, Dipak P. Ramji, Robert Andrews, You Zhou, James Burston, Ernest Choy
Summary: The study demonstrates the anti-inflammatory effects of pinolenic acid (PNLA) in human cell lines and peripheral blood mononuclear cells (PBMCs), and its impact on cell migration and macrophage function.
Article
Biochemistry & Molecular Biology
Lena Heinbockel, Gunther Weindl, Wilmar Correa, Julius Brandenburg, Norbert Reiling, Karl-Heinz Wiesmuller, Tobias Schuerholz, Thomas Gutsmann, Guillermo Martinez de Tejada, Karl Mauss, Klaus Brandenburg
Summary: Pep19-2.5 has been described as efficiently combating infection-inducing bacteria by binding and neutralizing their most potent toxins, LPS and LP, independent of bacterial resistance. Its mode of action involves both Coulomb/polar and hydrophobic interactions with the toxins, making it a promising therapeutic option against severe bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hongping Hou, Yujie Li, Ziying Xu, Zihui Yu, Bo Peng, Caixia Wang, Wei Liu, Wei Li, Zuguang Ye, Guangping Zhang
Summary: Nasal administration of Traditional Chinese medicine (TCM) has a long history. Most nasal preparations available on the market are compound formulations used for local treatments, but lack variety and diversity. This review summarizes the development and applications of different nasal preparations of TCM, including factors affecting absorption, common dosage forms, pharmacodynamics, targeting of nasal delivery, and safety.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Jose M. Prieto, Guillermo R. Schinella
Summary: This experimental review explores the relationship between Traditional Chinese Medicine (TCM) herbal drugs and lipid peroxidation in the context of topical inflammation. The study finds that certain herbal drugs with bitter and cold properties inhibit both lipid peroxidation and eicosanoids production, while sweet drugs specifically inhibit eicosanoids production. The therapeutic value of other drugs may be based on their actions on the Qi. The study suggests potential translation between the two medical systems and provides insights for the treatment of skin conditions.
Article
Biochemistry & Molecular Biology
Armando Alberola-Die, Jose Antonio Encinar, Raul Cobo, Gregorio Fernandez-Ballester, Jose Manuel Gonzalez-Ros, Isabel Ivorra, Andres Morales
Summary: Research shows that Peimine from Fritillaria bulbs inhibits nAChRs through various mechanisms, including open-channel blockade, enhancement of receptor desensitization, and resting-nAChR blockade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Roisin Lynch, Ed C. Lavelle
Summary: Biocompatible and biodegradable biomaterials are widely used in regenerative medicine. Inflammation, though initially essential for wound healing, can have negative effects if prolonged. Therefore, careful consideration should be given to the choice of biomaterials to minimize inflammation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Parasitology
Sara Benazzouz, Manel Amri, Junhua Wang, Samia Bouaziz, Fahima Ameur, Sara Djebbara, Karima Achour, Bruno Gottstein, Chafia Touil-Boukoffa
Summary: The laminated layer of Echinococcus granulosus (LL) significantly decreased nitric oxide (NO) production and interferon (IFN-?) mRNA levels in mouse spleen cells in response to lipopolysaccharide (LPS), while also down regulating interleukin 13 (IL-13) levels and upregulating transforming growth factor beta (TGF-β), Foxp3, and interleukin 10 (IL-10) expression. These findings suggest that LL may have potential immuno-regulatory and anti-inflammatory effects in controlling inflammation during inflammatory diseases.
Review
Medicine, General & Internal
Andre Farkouh, Christoph Baumgaertel, Roman Gottardi, Margit Hemetsberger, Martin Czejka, Alexandra Kautzky-Willer
Summary: There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Men tend to have stronger anti-thrombotic activity with COX-inhibitors, while women are more sensitive to corticosteroids when their estradiol levels are high. Research on sex differences in drug effectiveness and safety is growing, but findings are often anecdotal and controversial, with a lack of systematic sex-differentiated reporting in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Plant Sciences
Wei Zou, Linna Gong, Fenghua Zhou, Yao Long, Zhen Li, Zuoqi Xiao, Bo Ouyang, Menghua Liu
Summary: Penyanling has shown anti-inflammatory effects on PID rats by suppressing cell infiltrations and inflammatory mediator release, as well as promoting the production of lipoxin A4. It can also regulate NF-kappa B signal pathway and enhance inflammation resolution, with its main components being flavonoids, phenolics, saponins, and alkaloids.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio Vitiello, Francesco Ferrara
Summary: Low molecular weight heparin is a drug known for its anticoagulant properties, but recent evidence suggests that it may have additional anticoagulant effects and potential benefits in the treatment of COVID-19. The molecular mechanisms behind these pleiotropic effects are not fully understood.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Integrative & Complementary Medicine
Yan Liu, Xiaojie Li, Cai Chen, Aijing Leng, Jialin Qu
Summary: Mineral excipients play important roles in the pretreatment process of traditional Chinese medicines, but the lack of holistic understanding of their effects hinders their application and development. This review explores several mineral excipients, revealing their processing significance on traditional Chinese medicines through components, pharmacodynamics, and mechanism aspects.