Article
Multidisciplinary Sciences
Jing Yang, Chaotao Tang, Ruiri Jin, Bixia Liu, Peng Wang, Youxiang Chen, Chunyan Zeng
Summary: In this study, the bioactive components and potential targets of Huanglian jiedu decoction (HLJDD) in the treatment of ulcerative colitis (UC) were verified using network pharmacology and molecular docking. The study elucidated the multi-component, multi-target, multi-pathway mechanism of HLJDD in anti-UC for the first time, suggesting that HLJDD or its active components may be candidate drugs for the treatment of ulcerative colitis.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Xudong Cheng, Jun Du, Qing Zhou, Bensheng Wu, Haodong Wang, Zhizhong Xu, Shuguang Zhen, Jieyu Jiang, Xiaopeng Wang, Zongqi He
Summary: This study evaluated the therapeutic effects and molecular mechanisms of Huangkui lianchang decoction (HLD) in ulcerative colitis (UC). The results showed that HLD had a protective effect and could alleviate inflammation and tissue damage in UC mice. In vitro cell experiments demonstrated the anti-inflammatory effects of HLD and its inhibition of autophagy. These findings confirmed that HLD is an effective herbal preparation for the treatment of UC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-Hui Zhou, Qiang Zhang, Jiu-Chong Wang, Qing-Nan Wang, Zi-Ang Yao, Rui Qiang, Si-Tong Chen, Xin Zhao, Shuang Liu, Zheng-Min Cao, Lei Xu, Gao-Hui Li, Jing Chen, Li Wang
Summary: This study aims to test the integrative medicine (Chinese medicine plus antiviral therapy) effective on lowering hepatocellular carcinoma risk among patients with hepatitis-related compensated liver cirrhosis. It is a multi-center randomized controlled trial with 5 hospitals and 802 patients involved, focusing on the annual incidence of HCC as the primary outcome measure.
Article
Plant Sciences
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, An Wang, Changhao He, Zhongyu Shi, Shujing Zhang, Qian Fu, Wenhui Xu, Sumin Hu
Summary: This study confirmed the protective effects of YQJD decoction on ionizing radiation-induced spermatogenic cell injury. The findings may provide a new strategy for the application of Chinese herbs in radioprotection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guirong Chen, Xiaobo Wang, Chang Liu, Mingbo Zhang, Xueying Han, Yubin Xu
Summary: This study shows that the active components of Huanglian Jiedu Decoction (HJD) can treat sepsis by inactivating the LPS-TLR4/MD-2-NF-kappa B pathway. It is also found that the active component formulation (ACF) has similar efficacy and mechanism, reducing inflammatory cell infiltration and organ damage. Furthermore, ACF regulates certain metabolites, potentially alleviating physical damage caused by HJD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yi-Yu Qi, Xia Heng, Zeng-Ying Yao, Shu-Yue Qu, Ping-Yuan Ge, Xin Zhao, Sai-Jia Ni, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zhu
Summary: The study investigates the therapeutic effect of Huanglian Jiedu decoction (HLJDD) on Alzheimer's disease (AD) in relation to sphingolipid metabolism. The results show that HLJDD can potentially treat AD by correcting the abnormal sphingolipid metabolism in AD mice and BV2 cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Chen Xuan, Yu-Meng Xi, Yu-Di Zhang, Chun-He Tao, Lan-Yue Zhang, Wen-Fu Cao
Summary: The study found that YJHD can effectively improve renal function, alleviate renal pathological injury, protect podocytes, and reduce renal fibrosis. The mechanism may be related to the promotion of autophagy, inhibition of the mTOR pathway, and regulation of the PI3K/Akt and AMPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yuan Cui, Jingyi Hu, Yanan Li, Ryan Au, Yulai Fang, Cheng Cheng, Feng Xu, Weiyang Li, Yuguang Wu, Lei Zhu, Hong Shen
Summary: By utilizing network pharmacology, molecular docking, and animal experiments, this study confirmed that enema therapy with BYD has anti-UC efficacy by alleviating intestinal inflammation, protecting the intestinal barrier, and inhibiting the TOLL-like receptor pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Plant Sciences
Jin-Yong Zhou, Cunen Wu, Zhaofeng Shen, Shenlin Liu, Xi Zou, Jun Qian, Zhenfeng Wu, Xiangkun Huan, Bai-Xiang Mu, Ningyuan Ye, Yongbo Ning, Yaxing Wang, Min Chen, Yuwen Zhuang
Summary: YHJD, a polyherbal formulation, can inhibit liver metastasis of colorectal cancer by modulating the PI3K-AKT signaling pathway and enhancing the immune response mediated by natural killer cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Keke Luo, Haiyu Zhao, Baolin Bian, Xiaolu Wei, Nan Si, Adelheid Brantner, Xiaorui Fan, Xinru Gu, Yanyan Zhou, Hongjie Wang
Summary: This study investigated the therapeutic effect of Huanglian Jiedu Decoction on patients with Shanghuo, focusing on oral diseases, and explored the biochemical indicators and multi-omics analysis to reveal the intervention mechanism. The results demonstrated significant changes in inflammatory, oxidative stress factors, and metabolites after HLJDD intervention, suggesting potential pathways and biomarkers related to Shanghuo. The findings provide a foundation for further understanding the mechanism of HLJDD and identifying clinical biomarkers for Shanghuo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Wu Tong, Yang Zhiyun, Yang Yuying, Jiang Yuyong, Meng Peipei, Liu Huimin, Tian Yehong, Zhang Qiaoli
Summary: This study investigated the effect and underlying mechanism of Fuzheng Jiedu Xiaoji formula (FJXF) combined with chemoembolization (TACE) on primary liver cancer (PLC) patients. The combination therapy showed a better short-term clinical effect compared to TACE alone, possibly by alleviating multidrug resistance. Additionally, FJXF did not increase the risk of liver damage.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Article
Plant Sciences
Ya-Jun Li, Tao Zhou, Jing Zhang, Lei Zhang, Hai Ke, Cang Zhang, Ping Li
Summary: Our study found that active psoriasis is characterized by unbalanced immune status with dendritic cell and lymphocyte-associated inflammatory activation, as well as aberrant NK cell and B cell-associated defense response. LJD played an inhibitory role in T cell activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zixuan Liu, Wenxiang Wang, Jie Luo, Yingrui Zhang, Yunsen Zhang, Zhiqiang Gan, Xiaofei Shen, Yi Zhang, Xianli Meng
Summary: The review highlights the advantages of traditional Chinese medicine in treating endotoxemia and discusses the mechanisms of active ingredients like Sanhuang Xiexin Decoction and anisodamine in combating inflammation and apoptosis. Additionally, it explores the therapeutic effects of other natural anti-apoptotic products on endotoxemia and associated tissue injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yubin Xu, Saizhen Chen, Lingling Zhang, Guirong Chen, Jinguang Chen
Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Xianhai Li, Hua Tang, Qiang Tang, Wei Chen
Summary: Using network pharmacology, it was found that Huang-Lian-Jie-Du decoction treats pneumonia mainly by regulating the host immune inflammatory response, oxidative stress reaction, and antibacterial microorganisms. The therapeutic effect is greater on bacterial pneumonia compared to viral pneumonia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)