Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Review
Chemistry, Medicinal
Gheorghe Roman
Summary: This review provides a comprehensive account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure over the last decade.
ARCHIV DER PHARMAZIE
(2022)
Article
Veterinary Sciences
Olasunkanmi S. Olawuwo, Ibukun M. Famuyide, Lyndy J. McGaw
Summary: Antimicrobial resistant poultry pathogens pose a threat to both animal health and human health, and alternative products and strategies are being sought to reduce their prevalence. In this study, extracts from certain plant species showed potential as alternative feed additives in poultry production, with good antibacterial and anti-biofilm activities. Further studies are needed to evaluate their efficacy as herbal feed additives in vivo.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Uday M. Muddapur, Sultan Alshehri, Mohammed M. Ghoneim, Mater H. Mahnashi, Mohammed Abdulrahman Alshahrani, Aejaz Abdullatif Khan, S. M. Shakeel Iqubal, Amal Bahafi, Sunil S. More, Ibrahim Ahmed Shaikh, Basheerahmed Abdulaziz Mannasaheb, Noordin Othman, Muazzam Sheriff Maqbul, Mohammad Zaki Ahmad
Summary: Bionanotechnology has revolutionized modern science and technology, with plant-mediated synthesis of gold nanoparticles overcoming the drawbacks of traditional methods and offering tunable features for the development of medical diagnostics and therapeutics.
Article
Chemistry, Physical
Sunil L. Dhonnar, Rahul A. More, Vishnu A. Adole, Bapu S. Jagdale, Nutan Sadgir, Santosh S. Chobe
Summary: A series of 1,3,4-oxadiazole derivatives were synthesized and characterized. The synthesized compounds exhibited significant antibacterial and antifungal activity, as well as good antioxidant properties and low cytotoxicity. Three compounds showed higher antibacterial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Nanoscience & Nanotechnology
Margherita Izzi, Maria C. C. Sportelli, Luisa Torsi, Rosaria A. A. Picca, Nicola Cioffi
Summary: ZnO nanostructures (NSs) show significant antimicrobial activity and are highly biocompatible, chemically stable, and low in toxicity. This review focuses on the preparation and antimicrobial use of ZnO NSs. Different synthesis approaches including sol-gel, hydrothermal, biogenic, and electrochemical methods are discussed, along with their scalability, simplicity, and efficacy. The application of ZnO NSs in various fields and their antimicrobial mechanisms of action, cell resistance, and cytotoxicity are also highlighted. Additionally, the future prospects of ZnO NSs in this application field are addressed.
ACS APPLIED NANO MATERIALS
(2023)
Article
Multidisciplinary Sciences
Viji Paramasivam, Prema Paulpandian, Karthikeyan Venkatachalam, Shahid Hussain, Aleyna Kangal, Dunia A. Al Farraj, Mohamed S. Elshikh, Paulraj Balaji
Summary: This study aimed to synthesize gold nanoparticles using extracts from Andrographis paniculata leaves and evaluate their efficacy against MCF7 cells and selected human pathogens. The research concluded that gold nanoparticles derived from herbs have potential in cancer therapy and antimicrobial applications, but safe dosage and precise formulation are crucial.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Polymer Science
Amr H. Hashem, Amr M. Shehabeldine, Omar M. Ali, Salem S. Salem
Summary: This study successfully prepared chitosan-modified gold nanoparticles with efficient antimicrobial effects. The chitosan served as a reducing and stabilizing agent, resulting in spherical and monodispersed Chi/AuNPs. The Chi/AuNPs exhibited effective inhibitory effects against both bacteria and fungi, and demonstrated rapid and efficacious wound-healing ability in an in vitro wound-healing model.
Article
Multidisciplinary Sciences
Sadaf Laraib, Saiqa Sharif, Yamin Bibi, Sobia Nisa, Rukhsanda Aziz, Abdul Qayyum
Summary: The study evaluated the cytotoxic, antitumor, antimicrobial, and antioxidant properties of the methanolic and chloroform extracts of Myrsine africana fruit and leaf, finding that the methanol extracts performed better in all activities. Fruits showed higher cytotoxicity and tumor inhibition than leaves, while both extracts exhibited antibacterial and antifungal activity. Phytochemical analysis revealed the presence of beneficial compounds such as flavonoids, phenolics, terpenoids, steroids, and saponins in both extracts. Overall, the fruit extracts showed superior pharmacological properties and further studies are being conducted to identify and characterize the chemical compounds present.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Mareena Daus, Suttiwan Wunnoo, Supayang P. Voravuthikunchai, Saowanit Saithong, Preeyaporn Poldorn, Siriporn Jungsuttiwong, Natharika Chomlamay, Kanyaluck Yangok, Ramida Watanapokasin, Suda Chakthong
Summary: Fourteen undescribed phloroglucinol-meroterpenoids were isolated from Eucalyptus camaldulensis leaves, along with twelve known phloroglucinols, three known flavonoids, and four known phenolic compounds. The structures of the undescribed compounds were analyzed using NMR spectroscopy and mass spectrometry, and their cytotoxic, antibacterial, and antifungal activities were evaluated.
Article
Biochemistry & Molecular Biology
Reena Sangwan, Savita Beniwal, Seema Gaur, Phulwanti Sharma, Megha Mittal, Priyanka Sharma, Jyoti Sharma
Summary: In this study, four novel antimony and bismuth complexes were synthesized and structurally characterized. These complexes showed improved antibacterial and antifungal activities compared to their parent ligands, and exhibited cytotoxic effects on lung cancer cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Wei Liao, Xiaoyi Shi, Lian-gang Zhuo, Xia Yang, Peng Zhao, Wentao Kan, Guanquan Wang, Hongyuan Wei, Yuchuan Yang, Zhijun Zhou, Jing Wang
Summary: The study indicates that oligo-thiophene-ethynylene (OTE) with neutral amino groups exhibit better antibacterial activity in most cases compared to OTE with acyclic amino groups, and OTEs show better antibacterial activity than oligo-p-phenylene-ethynylenes (OPE).
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Diana Kichukova, Ivanka Spassova, Aneliya Kostadinova, Anna Staneva, Daniela Kovacheva
Summary: In this study, nanocomposites of reduced graphene oxide (RGO) with Cu and Ag were prepared using a facile and environmentally friendly method. The composites exhibited good antimicrobial activity and high cytotoxicity, making them potential candidates for antimicrobial and anticancer agents.
Article
Biochemistry & Molecular Biology
Denis Sudarikov, Yulia Gyrdymova, Alexander Borisov, Julia M. Lukiyanova, Roman Rumyantcev, Oksana G. Shevchenko, Diana R. Baidamshina, Nargiza D. Zakarova, Airat R. Kayumov, Ekaterina O. Sinegubova, Alexandrina S. Volobueva, Vladimir V. Zarubaev, Svetlana A. Rubtsova
Summary: New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time. The compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
Article
Biochemistry & Molecular Biology
Yi-Jie Xue, Ming-Yue Li, Xue-Jun Jin, Chang-Ji Zheng, Hu-Ri Piao
Summary: Novel carbazole derivatives containing different functional groups were synthesized and evaluated for their antimicrobial activities, showing potent inhibitory activities against various strains with low minimum inhibitory concentrations. The dihydrotriazine group was found to enhance antimicrobial potency and reduce toxicity, with compound 8f potentially exerting its antimicrobial effect by binding to dihydrofolate reductase.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Peng-Li Zhang, Lavanya Gopala, Shao-Lin Zhang, Gui-Xin Cai, Cheng-He Zhou
Summary: The study introduced a novel antibacterial framework and demonstrated through experiments that the new compound exhibited strong inhibition against MRSA, showed excellent membrane selectivity, and effectively alleviated bacterial resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yumei Li, Huijia Hu, Weifeng Zhang, Ziqi Tian, Xiaoqing Jiang, Yuheng Wang, Shaolin Zhang, Qiuju Zhang, Jiawen Jian, Jie Zou
Summary: This study used density functional theory to analyze the effect of Au doping on the performance of nitrogen oxide sensors in automobiles. It was found that Au can effectively weaken the adsorption energy of NO on platinum surfaces, thereby inhibiting the dissociation of NO.
Article
Computer Science, Artificial Intelligence
Zheng Wang, Wenbin Chen, Taifu Li, Shaolin Zhang, Rui Xiong
Summary: In this study, an improved YOLOv3 detection method for PCB plug-in solder spot defects was proposed, which combines ordered probability density weighting and attention mechanism to improve detection accuracy. Experimental results show that the average detection accuracy of the improved network is significantly improved and it has better convergence. This improved method is more suitable for industrial application of PCB plug-in solder spot defect detection.
Article
Chemistry, Medicinal
Ding Huang, Qingwang Liu, Maojie Zhang, Yizhen Guo, Zhiying Cui, Tao Li, Dong Luo, Biao Xu, Chao Huang, Jian Guo, Kin Yip Tam, Min Zhang, Shao-Lin Zhang, Yun He
Summary: A novel 4-CF3-phenyl triphenylphosphonium-based PBA conjugate (53) has been designed and identified with improved in vitro and in vivo anticancer activities. Compound 53 showed significantly higher potency against A375 cells with an IC50 value about 4000-fold higher than the parent drug PBA. In a xenograft mouse model, 53 exhibited a significant reduction in tumor growth at a lower dose compared to PBA.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Spectroscopy
Mingquan Ding, Huijun Liu, Hongtai Jiang, Mingde Huang, Xuexin Tan, Yanghai Li, Weiliang Wang, Shaolin Zhang, Haiming Huang
Summary: The vibrational, electronic and Raman properties of monolayer Ti2C under planar symmetrical strain excited by two commonly used laser lines are investigated. The results show that strained Ti2C exhibits notable red (blue) shift characteristic in its Raman peaks compared to unstrained Ti2C. The polarization angle also affects the Raman intensity in different configurations. This study provides insights for experimental characterization and understanding the effects of strain on Ti2C.
JOURNAL OF RAMAN SPECTROSCOPY
(2022)
Article
Green & Sustainable Science & Technology
Jin Yang, Yuanzhen Tang, Xingyang He, Ying Su, Jingyi Zeng, Mengyang Ma, Linghao Zeng, Shaolin Zhang, Hongbo Tan, Bohumir Strnadel
Summary: Geopolymer made from fly ash is a potential environmentally friendly and inexpensive alternative to high-emission cement production. In this study, wet-milling mechanical force and calcium hydroxide were used to prepare high-performance alkaline calcium activated geopolymers. Increasing the content of calcium hydroxide improved the strength and chloride resistance of the geopolymers, but also increased the autogenous shrinkage. Wet-milled fly ash geopolymers showed even greater improvements due to the pre-depolymerization effect of wet-milling and the activation effect of calcium hydroxide. The resulting geopolymers had significantly improved compressive strength and microstructure, and performed better than Portland cement in terms of environmental impact.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Materials Science, Multidisciplinary
Xinmei Xiang, Dehua Shao, Tong Pang, Tuan T. Ngo, Ngoc San Ha, Shaolin Zhang
Summary: This article proposes a biomimetic multilayer foam-filled structure (BMFS) and investigates its lateral compression performance through experimental and numerical analyses. The results show that BMFS exhibits a more advantageous sequential collapse deformation pattern for practical use.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2022)
Article
Chemistry, Medicinal
Ding Huang, Maojie Zhang, Haiyan Zhang, Zhiying Cui, Dong Luo, Tao Li, Xuemin Li, Yun He, Shao-Lin Zhang
Summary: In this study, the toxic effects of mitomycin C (MMC), an anticancer drug, were reduced by attaching triphenylphosphine groups (TPP+) to it. The resulting compound, 5, showed good anticancer activity and negligible toxicity to human normal cells. In mice, 5 had little effect on body weight and tissues, indicating reduced toxicity compared to MMC. These findings suggest that TPP+ can effectively reduce the toxicity of MMC.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Engineering, Environmental
Yue Li, Qian-Li Li, Yan Li, Yun-Ling Yang, Shao-Lin Zhang, Jingtai Zhao, Jieqiong Wan, Zhijun Zhang
Summary: Methylammonium lead halide perovskites have poor stability towards moisture. Strategies such as encapsulation and surface engineering can improve moisture stability and optical/electronic performance. In this study, a hydrophobic polymer matrix was used for encapsulation, resulting in a composite film with enhanced fluorescence and improved luminous efficiency. The film also showed high sensitivity and low detection limit for X-ray irradiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Civil
Xinmei Xiang, Chenkun Xiao, Ngoc San Ha, Guoxing Lu, Shaolin Zhang, Yijie Liu
Summary: This paper designs bioinspired thin-walled structures based on observations of barnacles and studies their mechanical properties. The effects of the number and amplitude of corrugations on the deformation and energy absorption performance of 3D printed bioinspired tapered tubes are investigated. The results show that properly controlling corrugation parameters can significantly improve energy absorption.
ENGINEERING STRUCTURES
(2023)
Article
Agriculture, Multidisciplinary
Jing Zhang, Narsaiah Battini, Jia-Ming Ou, Shao-Lin Zhang, Ling Zhang, Cheng-He Zhou
Summary: New antibacterial 3-(aminothiazolyl)quinolones were synthesized to combat multidrug resistance in animal husbandry. Bioactive assays showed that N,N-dicyclohexylaminocarbonyl ATQ 10e and methyl ATQ 17a exhibited better antibacterial behavior against Staphylococcus aureus and Pseudomonas aeruginosa than norfloxacin. Mechanism exploration indicated that ATQ 17a could inhibit biofilm formation, disrupt bacterial membrane integrity, bind to intracellular DNA and DNA gyrase, induce reactive oxygen species production, and reduce bacterial metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Shaolin Zhang, Qianglong Ma, Shangkun Cheng, Dong An, Zhenling Yang, Biao Ma, Yang Yang
Summary: A crop row detection algorithm based on LiDAR is proposed in this paper for middle and late crop periods, which shows good detection results in high sheltering environments. The algorithm demonstrates accuracy and superiority over the machine vision algorithm, providing a solid foundation for autonomous navigation in agriculture.
Article
Engineering, Mechanical
Hong Guo, Jianqiao Bao, Shaolin Zhang, Minghui Shi
Summary: This paper presents a misaligned journal mixed lubrication model coupling for multiple factors, and applies the finite difference method to calculate the model and experimental validation. The results show that under misalignment conditions, the pressure field, film thickness, and elastic deformation of the bearing have asymmetric distribution and end side effect. Additionally, the frictional force and side leakage flow are enhanced with the increase in inclination angle within a certain range.
Article
Chemistry, Medicinal
Yi-Min Tan, Ya Wang, Shuo Li, Shao-Lin Zhang, Cheng-He Zhou
Summary: A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were developed. Some synthesized compounds showed excellent bacteriostatic potency; especially, triazolylpyrimidinediol (triadol PD) 7a exhibited good anti Acinetobacter baumannii potential with a low MIC of 0.002 mmol/ L. Mechanistic explorations revealed that compound 7a without membrane-targeting ability could decrease metabolic activity, interact with DNA through groove binding action to block DNA replication rather than intercalate into and cleave DNA, and thus inhibit bacterial growth.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Mechanical
Minghui Shi, Hong Guo, Shaolin Zhang, Shujie Chen, Fengcheng Fan
Summary: In this study, surface texture was introduced into ultrasonic levitation bearing to obtain greater load capacity. A theoretical model considering the geometry parameters and mode shape was established and solved using the eight-point discrete grid finite-difference method. The influence of various parameters on load capacity was systematically investigated, and the feasibility of the model was verified using previous experimental results. The results show that positive texture can effectively improve the load capacity of ultrasonic levitation bearing, especially under ultrasonic levitation mode. This research provides insights into the lubrication mechanism of ultrasonic levitation bearing and promotes its practical application in engineering.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
