Article
Engineering, Environmental
Stephanie L. Rich, Michael T. Zumstein, Damian E. Helbling
Summary: The research aimed to identify functional groups that influence rates of micropollutant biotransformation in wastewater microbial communities. Through incubation experiments and random forest models, 30 functional groups were classified as biotransformation promoters, inhibitors, features that can be transformed, or features that are not rate-determining, providing new insights for predicting micropollutant biotransformations and designing more biodegradable chemical products for wastewater treatment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemical Research Methods
Joong-Hoon Ahn, Yoojin Chong, Shin -Won Lee
Summary: Plants produce various types of phenolic compounds, and the biological importance of phenolic C-glycosides has led to the exploration of their synthesis. Different classes of C-glycosyltransferases have been identified and classified based on the type of sugar acceptor. Recent progress in the development and application of these enzymes in microbial systems has enabled the synthesis of phenolic C-glycosides.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Liqiu Su, Yanbing Shen, Zhiyan Liu, Xuening Sheng, Yanan Zhu, Jianxin Wang, Jingjing Liu, Min Wang
Summary: By incubating palygorskite (Pal) and modified Pal with Mycobacterium neoaurum TCCC 11979 (MNR), the effects of Pal on phytosterols (PS) biotransformation were investigated. The results showed that Pal or modified Pal as a carrier remarkably improved the production of the steroid medicine intermediate androst-4-ene-3, 17-dione (AD). This study expands the application of Pal in the pharmaceutical industry and enhances our understanding of the mechanism underlying the effect of Pal on the bioconversion of hydrophobic compounds.
APPLIED CLAY SCIENCE
(2023)
Article
Environmental Sciences
Moustapha Harb, Ali Zarei-Baygi, Phillip Wang, Christelle BouNehme Sawaya, L. Daniel McCurry, B. Lauren Stadler, L. Adam Smith
Summary: This study investigated the transformation of antibiotics in anaerobic membrane bioreactor (AnMBR) and identified microbial communities that may facilitate the conversion of sulfamethoxazole and ampicillin. The relative activity of suspended biomass in the system shifted towards syntrophic groups during the experiment, showing notable differences from membrane biofilm communities. The high activity of specific methanogenic, syntrophic, and sulfate-reducing groups in membrane-attached biofilms likely contributes to the biotransformation of antibiotics.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Anqi Zhao, Xiaoqin Zhang, Yamei Li, Zhi Wang, Yongkun Lv, Jinle Liu, Md. Asraful Alam, Wenlong Xiong, Jingliang Xu
Summary: Steroid-based drugs have become the second largest medical category in pharmaceutics. The biosynthesis of steroid-based drug intermediates from phytosterols by Mycolicibacterium cell factories offers advantages in multiple ways, providing a new pathway for the production of steroid-based drug intermediates.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Environmental Sciences
Manxin Xu, Ge Zhang, Yang Qiu, Yongtao Li, Churong Liu, Xingjian Yang
Summary: The biotransformation outcomes of synthetic progestins in agricultural soils are influenced by soil properties and microbial communities. The assessment of environmental risks associated with these compounds should consider these factors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Microbiology
Veni Pande, Satish Chandra Pandey, Diksha Sati, Pankaj Bhatt, Mukesh Samant
Summary: The contamination of heavy metals in soil poses significant threats to the environment and human health. Microbial bioremediation, which utilizes microorganisms to remove heavy metals, has emerged as a promising alternative approach. This review provides a comprehensive assessment of the bioremediation capabilities of microorganisms and summarizes various processes involved in heavy metal removal, including biosorption, bioleaching, biomineralization, biotransformation, as well as the use of genetically modified microbes and immobilized microbial cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Environmental Sciences
Youn Jeong Choi, Damian E. Helbling, Jinxia Liu, Christopher Olivares, Christopher P. Higgins
Summary: This review examines the microbial biotransformation of polyfluoroalkyl substances derived from aqueous film-forming foam (AFFF). The analysis reveals that there is more knowledge about the aerobic microbial biotransformation of these substances compared to anaerobic biotransformation. Dealkylation, oxidation, and hydrolytic reactions are found to be important for the microbial biotransformation of AFFF-derived polyfluoroalkyl substances. The review also discusses knowledge gaps and opportunities for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Monica E. McFadden, Keith P. Reber, John D. Sivey, David M. Cwiertny, Gregory H. LeFevre
Summary: Microbial biotransformation of benoxacor and dichlormid primarily occurs via cometabolism, leading to the formation of novel products including monochlorinated species, glutathione conjugates, and sulfur-containing species. Dechlorination followed by conjugation with glutathione is proposed as the main transformation pathway.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Lijia Cao, Sarahi L. Garcia, Christian Wurzbacher
Summary: This study investigated a wide range of TOrC biotransformation based on different model communities derived from varying natural microbial systems. The study provides a standardized workflow of establishing model communities for different metabolic purposes, and the obtained model communities can be used to find the driving agents of TOrC biotransformation.
MICROBIAL CELL FACTORIES
(2023)
Review
Chemistry, Multidisciplinary
Shuyu Guo, Chunqiao Xiao, Na Zhou, Ruan Chi
Summary: Soil contamination by toxic chromium is a rising health issue, but can be mitigated through bioremediation, phytoremediation, and plant-microbial combined remediation. Different remediation methods have their own mechanisms and applications, but there may still be remaining ecological impacts after bioremediation.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Engineering, Environmental
Zhuo Gao, Shujun Yi, Mengzhu Xue, Kecheng Zhu, Rongyan Yang, Tiecheng Wang, Hongwen Sun, Lingyan Zhu
Summary: The microbial biotransformation of C6/C6 and C8/C8 PFPiA in two soils was investigated. The levels of PFPiAs decreased significantly, accompanied by the formation of PFHxPA and PFOPA. The half-lives of the PFPiAs were longer in Soil Y than in Soil N and C8/C8 PFPiA had a longer half-life than C6/C6 PFPiA. Proteobacteria were identified as the primary host of functional genes related to C-P bond cleavage, playing a crucial role in the biotransformation of PFPiAs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Carla S. S. Ferreira, Miguel Oliveira, Mario Pacheco, Maria Ana Santos
Summary: The physiological conditions of an organism and its ability to cope with environmental stresses are influenced by the interaction between biotransformation and the endocrine system. However, the interaction between hormones and response to pollutants like PAHs is not well understood. This study aimed to increase knowledge regarding the effects of steroid hormones on the inhibition of ethoxyresorufin-O-deethylase (EROD) activity by contaminants. The findings suggest that cortisol and 17β-estradiol can help prevent the inhibitory effects of PAHs on biotransformation enzymes, highlighting the physiological relevance of these hormones.
APPLIED SCIENCES-BASEL
(2022)
Article
Plant Sciences
Safwat A. Ahmed, Amany K. Ibrahim, Mohamed M. Radwan, Desmond Slade, Suman Chandra, Ikhlas A. Khan, Mahmoud A. ElSohly
Summary: Microbial biotransformation of cannabidiol was studied using 31 different microorganisms, with only three species capable of metabolizing cannabidiol and producing various metabolites. These metabolites were evaluated for their antimicrobial and antiprotozoal activities.
Article
Integrative & Complementary Medicine
Duan Hai-Yan, Wang Jian, Zha Liang-Ping, Peng Hua-Sheng, Zhao Yu-Ping, Yuan Yuan, Huang Lu-Qi
Summary: A study identified an O-glucosyltransferase (PtUGT8) in Pueraria thomsonii, which has the ability to glycosylate specific positions of isoflavonoids. The enzyme is inactive towards flavonoids. This discovery may provide a useful catalyst for efficient biotransformation of isoflavonoids and other natural products.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
