Article
Chemistry, Applied
Huaixiu Wen, Xiang Yuan, Caixia Li, Jun Li, Huilan Yue
Summary: Two new isoquinoline alkaloids, along with five known compounds, were isolated from Hypecoum leptocarpum. The structures of these compounds were determined using spectroscopic techniques, and their cytotoxic activities were evaluated. Some of the compounds showed moderate cytotoxicity against lung cancer and gastric carcinoma cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemical Research Methods
Yubo Fang, Han Xiao
Summary: Efficient secretion of triterpenoids can be achieved by overexpressing YPS3 and SCW10 genes in engineered Saccharomyces cerevisiae strains, resulting in increased production of GA-HLDOA and changes in cell permeability and outer mannan layer.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Applied
Hnin Thanda Aung, Khin Thidar Saw, Mi Mi Latt, Giovanni Vidari, Yumiko Komori, Yoshiaki Takaya
Summary: The first phytochemical investigation of specialized metabolites from the stem bark of Alyxia fascicularis was conducted. Five lignans and three coumarins were isolated and identified. The lignans showed significant radical scavenging activity. The compounds had no cytotoxic effect on Hela cell line. A possible biosynthetic pathway was suggested.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lei Wan, Jian Liu, Chuanbing Huang, Kun Wang, Ziheng Zhu, Fangze Li
Summary: This study validated the therapeutic effect of Tripterygium wilfordii Hook. f. in rheumatoid arthritis by restoring the homeostasis of M1/M2 macrophages. It was found that Triptolide, a component of Tripterygium wilfordii, downregulated the expression of factors secreted by M1 macrophages and inhibited inflammatory signaling pathways.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Manh Dung Doan, San-Lang Wang, Van Bon Nguyen, Thi Kim Phung Phan, Tu Quy Phan, Tan Thanh Nguyen, Thi Huyen Nguyen, Quang Vinh Nguyen, Anh Dzung Nguyen
Summary: This study reported the phytochemical profiles and bioactivities of the medicinal plant Dillenia ovata Wall. ex Hook. f. et Thomson (DOWHT). The bioactivities testing indicated that DOWHT showed inhibition against key enzymes related to diabetes and Alzheimer's disease, and the phytochemical profiles of DOWHT were investigated. In silico results suggested that DOWHT could be a potential source for drug discovery.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
