Article
Engineering, Chemical
Dan-Na Hu, Xiao-Jie Ju, Xing-Qun Pu, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: The copolymer Alg-g-PNA shows temperature and glucose responsiveness, with the ability to transition between sol and gel states for insulin delivery based on environmental conditions. Additionally, the hydrogels demonstrate good biocompatibility and reversible sol-gel transitions in response to changes in blood glucose levels, making them a promising option for self-regulating insulin delivery in diabetes therapy.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Polymer Science
Yiluo Hu, Yohan Kim, Inki Hong, Moosung Kim, Seunho Jung
Summary: Agarose/succinoglycan hydrogels exhibit significantly improved flexibility, stability, and swelling pattern compared to agarose gels alone, and they also demonstrate pH-responsive drug delivery of ciprofloxacin. The non-toxicity of these hydrogels makes them potential natural biomaterials for biomedical applications.
Article
Engineering, Environmental
Adetunji Alabi, Linda Zou
Summary: Alginate-polyacrylate hydrogels and graphene oxide-incorporated alginate-polyacrylate hydrogels were synthesized and found to possess the ability to continuously draw water across an osmotic membrane. The hydrogels showed superhydrophilic surfaces. The superior water production of the graphene oxide-incorporated hydrogels was attributed to the combined effect of the osmotic potential-inducing polyacrylate and the flexible graphene oxide nanosheets.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Article
Polymer Science
Jae-pil Jeong, Kyungho Kim, Jaeyul Kim, Yohan Kim, Seunho Jung
Summary: In this study, new hydrogels were fabricated using polyvinyl alcohol (PVA) and succinoglycan (SG) obtained from Sinorhizobium meliloti Rm 1021. The hydrogel composition and freeze-thaw cycles were optimized to enhance the swelling ratio. The optimized hydrogel exhibited pH-responsive drug release and was non-toxic and biocompatible, making it a potential candidate for chronic wound dressing applications.
Review
Biotechnology & Applied Microbiology
Udaykumar Vegad, Megha Patel, Dignesh Khunt, Ozbej Zupancic, Sanjay Chauhan, Amrit Paudel
Summary: In recent decades, there has been significant progress in the design and development of biomaterials based on non-cellulosic biological macromolecules. Stimuli-responsive hydrogels made from non-cellulosic biological macromolecules have gained attention due to their unique physicochemical properties, biological characteristics, and sustainability. pH-responsive hydrogels have the ability to release therapeutic substances in response to pH changes, leading to tailored drug administration, reduced side effects, and improved treatment efficacy. pH-sensitive biopolymers such as chitosan, alginate, hyaluronic acid, guar gum, and dextran have been widely used in various applications, including drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Parker Toews, Jeffrey Bates
Summary: Drug release kinetics in methacrylate hydrogels were modified by adjusting the molecular weight of the hydrogels, leading to increased stability and enhanced release performance. Spectroscopy techniques provided insights into the chemical structure, target molecule concentration, and optical performance of the hydrogels.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: A physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate was developed for the delivery of ketoprofen. The hydrogel showed outstanding hydrophobic drug loading and sustained release, as well as pH responsiveness, making it a potential candidate for hydrophobic drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Jie Zhu, Rui Gao, Zhongshi Wang, Zhiming Cheng, Zhonghua Xu, Zaiyang Liu, Yiqun Wu, Min Wang, Yuan Zhang
Summary: A pH-responsive nonapeptide hydrogel was designed and fabricated for tumor-targeted drug delivery, which exhibited good injectability and biocompatibility. The drug-loaded hydrogel showed high sensitivity to acidic conditions and could amplify the therapeutic effect and increase drug accumulation at the tumor site in vivo.
Article
Polymer Science
Munir Ahmad Khan, Abul Kalam Azad, Muhammad Safdar, Asif Nawaz, Muhammad Akhlaq, Pijush Paul, Md. Kamal Hossain, Md. Habibur Rahman, Roua S. Baty, Attalla F. El-kott, Mohamed Kamel, Simona G. Bungau, Mohamed M. Abdel-Daim
Summary: This study aimed to synthesize and characterize pH-sensitive hydrogels loaded with 5-fluorouracil and investigate their controlled release properties. The formulations exhibited different swelling and release behaviors at different pH conditions, suggesting their potential as oral controlled colon drug delivery carriers.
Article
Biochemistry & Molecular Biology
Chloe Seyrig, Alexandre Poirier, Thomas Bizien, Niki Baccile
Summary: This study demonstrates the development of functional hydrogels with in situ responsivity of their elastic properties by external stimuli, using entirely sustainable materials. The elastic properties of the hydrogels can be modulated by selectively triggering the phase transition of the components.
Article
Polymer Science
Ya-Qiang Wang, Xue-Yu Dou, Hu-Fei Wang, Xing Wang, De-Cheng Wu
Summary: The study successfully developed a POSS-ace-PEG hydrogel adhesive with good mechanical and adhesive properties, and demonstrated different stability and release characteristics in various acid-base environments, showing potential for applications in pathological environments.
CHINESE JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Applied
Huong Thi Hoang, Sung-Han Jo, Quoc-Thang Phan, Hansol Park, Sang-Hyug Park, Chul-Woong Oh, Kwon Taek Lim
Summary: A dual pH-/thermo-responsive hydrogel was successfully designed using a polyelectrolyte complex and chemical crosslinking, demonstrating high drug loading capacity and controlled drug release properties at different pH levels, showing promising applications in colon-targeted drug delivery systems.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Zahra Shariatinia, Mahdieh Ziba
Summary: Chitosan was functionalized and utilized as smart pH-responsive drug delivery systems for the anticancer drug cyclophosphamide. Different synthesized materials showed varied drug release rates under different pH conditions, with CS-AC-U-CP being identified as the most desirable DDS.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhiqiang Lin, Junfeng Ding, Xuesi Chen, Chaoliang He
Summary: pH- and temperature-responsive hydrogels based on mPEG-polypeptide block copolymers were developed in this study. The hydrogels exhibited an alpha-helix-to-beta-sheet transition at increased pH and underwent thermo-induced sol-gel phase transitions at elevated polymer concentrations, dependent on the pH. They demonstrated good histocompatibility and almost complete degradation in the subcutaneous layer of mice. The doxorubicin-loaded hydrogels showed pH-responsive drug release profiles with rapid release at acidic pH and sustained release at neutral pH, suggesting their potential as environment-responsive depots for drug delivery.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Polymer Science
Demet Kaya Aktas, Filiz Oztekin
Summary: Ionic hydrogels are suitable for drug delivery applications, and in this study, pH-sensitive P(AAc-co-AAm) hydrogels were investigated for swelling properties using a hydrophilic fluorescence probe, 4sPy. The fluorescence intensity of 4sPy was monitored during swelling processes at different pH values, showing similar behavior to trapped drug carriers. These hydrogels could be useful for targeted drug delivery systems in the jejunum, with potential for 4sPy as a monitoring probe for drug carriers.
