期刊
CHINESE CHEMICAL LETTERS
卷 25, 期 3, 页码 419-422出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2013.12.017
关键词
Water promoted; Antibacterial; 1,2,3-Triazole; Pyrimidine
资金
- UGC (BSR)
- DST-PURSE
- Department of Science and Technology, New Delhi, India
An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent. (C) 2013 Alagusundaram Ponnuswamy and Vellasamy Shanmugaiah. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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