Article
Environmental Sciences
Vijayakumar Gunasekaran, Rathinam Yuvakkumar, Ravi Ganesan, Surya Cholayil Palapetta, Harichandran Gurusamy
Summary: In this study, NBA and ABA were synthesized and evaluated for their cell multiplication inhibition activity against MCF-7 and HeLa cancer cell lines. The results showed that both NBA and ABA exhibited antiproliferative action against these cancer cell lines.
ENVIRONMENTAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Jerry O. Adeyemi
Summary: Nickel oxide (NiO) nanoparticles with a spherical-shaped structure and an average crystallite size of 9 mm were successfully synthesized using the leaf extracts of Kei-apple (Dovyallis Caffra). The nanoparticles exhibited good cytotoxicity against Human embryo kidney (HEK 293) and Human cervical cancer (HeLa) cell lines, with IC50 values of 0.00015 and 13.8 & mu;g mL(-1), respectively. However, they showed a weak anti-inflammatory effect in the Bovine serum albumin denaturation assay. The findings suggest that the Kei-apple mediated NiO nanoparticles can be safely used in various fields without causing significant harm to the human body.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Chemistry, Physical
Sumit Thakral, Devinder Kumar, Suman Rani, Ramesh Kataria, Poonam Sagar, Nitin Kumar Singhal
Summary: A library of 2'-aryl-2,5'-bibenzoxoles was synthesized and characterized. Compounds 8p, 8k, and 8t showed good cytotoxicity against cervical cancer cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Elcin Bakir, Tugbagul Cal, Sevtap Aydin Dilsiz, Hande Canpinar, Ayse Eken, Ulku Undeger Bucurgat
Summary: The study found that flurbiprofen has cytotoxic, genotoxic, and apoptotic effects in human cancer cells, potentially inducing apoptosis at the gene level.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Ecology
Xiaohuan Zhao, Xinpeng Fan, Zhiwei Gong, Xilei Gao, Yiwen Wang, Bing Ni
Summary: This study investigated the toxic effects of copper (Cu) and copper oxide (CuO) nanoparticles on the single-celled eukaryote Euplotes aediculatus. The nanoparticles increased the activities of antioxidant enzymes and caused damage to the cell structure, with Cu nanoparticles being more toxic than CuO nanoparticles. Additionally, Cu nanoparticles resulted in nucleoli disappearance, chromatin condensation, and damage to mitochondria and the pellicle. The oxidation of functional groups on the membrane further confirmed the severe damage caused by Cu nanoparticles. Overall, oxidative stress and organelle destruction played important roles in the toxic effects of these nanoparticles on E. aediculatus.
Article
Biochemistry & Molecular Biology
Afsheen Mansoor, Zohaib Khurshid, Emaan Mansoor, Muhammad Talal Khan, Jithendra Ratnayake, Asif Jamal
Summary: Nanotechnology plays a significant role in dental applications, but the safety of its use still raises concerns regarding human health. This study developed titanium nanoparticles using three novel methods and evaluated their cytotoxicity. The results showed that titanium nanoparticles produced by Bacillus subtilis were the safest and most suitable for future restorative dentistry purposes.
Article
Chemistry, Physical
Ala Manohar, S. V. Prabhakar Vattikuti, Panchanathan Manivasagan, Eue-Soon Jang, Heba Taha M. Abdelghani, Ki Hyeon Kim
Summary: This study investigates the effect of size variation in CeO2/MgFe2O4 nanocomposites on their electrochemical performance and cytotoxicity. The nanocomposites were synthesized using a combustion process and different calcined temperatures to adjust the particle size. The results show that the nanocomposites exhibit good biocompatibility and favorable electrochemical performance, suggesting their potential for biological applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Electrical & Electronic
Ankush Kumar Tangra, Gurmeet Singh
Summary: Biocompatible KFeO2 superparamagnetic nanoparticles were synthesized and characterized for their structure, morphology, magnetic properties, and toxicity. The nanoparticles exhibited a high cell viability and superparamagnetic behavior, with an average particle size of 13 nm and an orthorhombic crystal structure. The study also presented factors affecting nanoparticle toxicity and their incorporation and degradation mechanisms.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Kavitha Alapati, Savithri S. Handanahal
Summary: Cholesterol oxidase demonstrates potent anticancer effects by affecting cell morphology and apoptotic protein expression, leading to a decrease in cell viability. Experiments show that this enzyme can exert cytotoxicity against human cancer cell lines at very low concentrations.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marketa Havrdova, Iztok Urbancic, Katerina Barton Tomankova, Lukas Malina, Katerina Polakova, Janez Strancar, Athanasios B. Bourlinos
Summary: Fluorescent carbon dots (CDs) are potential tools for cell labeling due to their advantageous properties. In this study, the researchers investigated the intracellular trafficking and cytotoxicity of cationic quaternized carbon dots (QCDs) in human cancer cell lines MCF-7 and HeLa. They found that QCDs uptake in MCF-7 cells resulted in cell death within the first two hours, with faster death at lower doses. QCDs at a concentration of 100 μg/mL entered the nucleus before cellular death, while at 200 μg/mL dose, QCDs penetrated into the nuclear area after causing blebbing of the cellular membrane. In HeLa cells, dose-dependent effects did not occur, but cell death in mitosis and genotoxicity were observed at all doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Jaggaiah N. Gorantla, Sunaree Choknud, Eko Suyanto, Htun-Htun Win, Yanling Hua, Maniganda Santhi, Sirilak Wangngae, Anyanee Kamkaew, Mariena Ketudat-Cairns, Lalida Rojanathammanee, James R. Ketudat Cairns
Summary: In this study, various hydroxycinnamic and hydroxybenzoic acids were easily converted to phenolic amides (PAMs) through a one-step BOP-mediated amide coupling reaction. Fifteen PAMs were synthesized with yields above 40% and evaluated for cytotoxic activities against four cancer cell lines. Four amides exhibited promising IC50 values ranging from 5 to 55 μM, while tetradecyl-gallic-amide (13) specifically showed significant inhibitory effects on THP-1 leukemia cells with an IC50 value of 3.08 μM. These findings highlight the potential of phenolic amides as anticancer agents.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhi Guo, Mingming Li, Baofu Li, Jungong Jin, Yafei Gao
Summary: With technological advances in molecular techniques and bioinformatics, significant information has been gained in cancer early diagnosis. Studying natural agents like plants nanocompounds is crucial for cancer treatment research. Copper nanoparticles synthesized with green chemistry rules using Boswellia thurifera extract have shown potential as an anti-carcinoma supplement in humans.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Matthias Balk, Theresa Haus, Julia Band, Harald Unterweger, Eveline Schreiber, Ralf P. Friedrich, Christoph Alexiou, Antoniu-Oreste Gostian
Summary: This study investigated the magnetic properties, cellular uptake, and biocompatibility of two different types of SPIONs through various analytical methods. The results suggest the potential use of SPIONs as vehicles for MDT in head and neck cancer.
Article
Pharmacology & Pharmacy
Timur R. Nizamov, Artem R. Iliasov, Stepan S. Vodopyanov, Irina V. Kozhina, Igor G. Bordyuzhin, Dmitry G. Zhukov, Anna V. Ivanova, Elizaveta S. Permyakova, Pavel S. Mogilnikov, Daniil A. Vishnevskiy, Igor V. Shchetinin, Maxim A. Abakumov, Alexander G. Savchenko
Summary: This study investigates the application of redox-responsive and magnetic nanomaterials in tumor treatment. The research demonstrates that magnetic redox-responsive nanoparticles (MNP-SS) lose their colloidal stability and aggregate in certain conditions, while PEGylated MNP (MNP-PEG) remains stable. MNP-SS show enhanced cellular uptake and cytotoxicity due to faster dissolution of the iron oxide core and release of iron ions inside cancer cells. This kind of synergistic effect has great potential in drug delivery and treatment of tumors responsive to ferroptosis.
Article
Biochemistry & Molecular Biology
Rafal Kretowski, Agata Jablonska-Trypuc, Marzanna Cechowska-Pasko
Summary: This study evaluated the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. The results showed that 5-15 nm SiNPs induced dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cells, and also induced apoptosis through decreasing mitochondrial membrane potential and increasing the activity of caspase-9 and caspase-3. Additionally, these nanoparticles caused an increase in selected oxidative stress parameters in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)