期刊
CHINESE CHEMICAL LETTERS
卷 25, 期 11, 页码 1435-1440出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.06.027
关键词
Self-assembled micelles; Methoxy polyethylene glycol grafted chitosan; 5-Fluorouracil; Controlled-release
资金
- Fundamental Research Funds for the Central Universities [WY1213013ECUST]
- Science and Technology Commission of Shanghai Municipality (STCSM) [11DZ2260600, 10DZ2220500]
The objective of this study was to investigate the potential of methoxy polyethylene glycol (mPEG) grafted chitosan (mPEG-g-CS) to be used as a drug carrier. mPEG-g-CS was successfully synthesized by one-step method with formaldehyde. The substitution degree of mPEG on chitosan was calculated by elemental analysis and was found to be (3.23 +/- 0.25)%. mPEG-g-CS self-assembled micelles were prepared by ultrasonic method with the controlled size of 178.5-195.1 nm and spherical morphology. Stable dispersion of the micelles was formed with the zeta potential of 2.3-30.2 mV. 5-Fluorouracil (5-FU), an anticancer chemotherapy drug, was used as a model drug to evaluate the efficiency of the new drug delivery carrier. The loading efficiency of 5-FU was (4.01 +/- 0.03)%, and the drug-loaded mPEG-g-CS self-assembled micelle showed a controlled-release effect. In summary, the mPEG-g-CS self-assembled micelle is proved to be a promising carrier with controlled particle size and controlled-release effect. Therefore, it has great potential for the application as 5-FU carriers for effective anti-tumor activity. (C) 2014 Feng Gao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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