Article
Chemistry, Organic
Li Jingjie, Wang Yuhao, Meng Tiantian, Huang Yiyong
Summary: A P(4-OMe-C6H4)(3)-catalyzed Michael addition/double bond migration tandem reaction between allenyl imide and indol-2-ones has been developed. This synthetic strategy allows for the synthesis of diverse 1,3-dihydro-3-alkylidene-2H-indol-2-ones and features operationally simple procedures, good substrate scope, high chemoselectivity, and mild reaction conditions. The proposed reaction mechanism is also elucidated.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Emilija Milovic, Nenad Jankovic, Jelena Petronijevic, Nenad Joksimovic, Marijana Kosanic, Tatjana Stanojkovic, Ivana Matic, Nada Grozdanic, Olivera Klisuric, Srdan Stefanovic
Summary: This paper describes the synthesis, characterization, and biological evaluation of novel tetrahydropyrimidines (THPMs). These compounds exhibit wide pharmacological activities, including antimicrobial, antifungal, and anticancer properties. The study shows that compounds 4a, 4b, and 4d have the highest antibacterial activity, while compounds 4e, 4f, and 4k exhibit the best antifungal activity. Compound 4g demonstrates the strongest alpha-glucosidase inhibitory activity. The cytotoxicity tests on tumor cell lines indicate that compounds 4b and 4k show promising anticancer activity against HeLa cell lines. The research also examines the cell cycle and mechanism of action of the most active compounds.
Article
Chemistry, Organic
Lukas Marek, Lukas Kolman, Jiri Vana, Jan Svoboda, Jiri Hanusek
Summary: A highly modular method for synthesizing (Z)-3-[amino(phenyl/methyl)methylidene]-1,3-dihydro-2H-indol-2-ones starting from easily available starting materials was developed. The method yields a series of compounds with significant tyrosine kinase inhibiting activity, surpassing other published methods in terms of yield. The method includes an Eschenmoser coupling reaction and the confirmation of (Z)-configuration for all products using NMR techniques.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Ailipire Aisikaer, Jing Ma, Jiajia Li, Xiaojuan Li
Summary: A simple synthetic strategy for 3-substituted 3-azido-1,3-dihydro-2H-indol-2-ones was achieved through hydroazidation of phenacylideneoxindoles with azidotrimethylsilane under mild conditions. The reaction proceeds by the anti-electron addition of N3 in the presence of tetrabutylammonium fluoride. This azi-dation method of phenacylideneoxindoles is valuable in pharmaceutical synthesis and chemical biology studies due to its mild reaction conditions and simple purification of products without contamination by any transition-metal residues.
TETRAHEDRON LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Bastien Champciaux, Clement Raynaud, Albertus Viljoen, Loic Chene, Jerome Thibonnet, Stephane P. Vincent, Laurent Kremer, Emilie Thiery
Summary: This study focuses on the synthesis of 1,7- and 3,4-indole-fused lactones via a simple and efficient reaction sequence, with the evaluation of their activity against Mycobacterium tuberculosis showing that the oxazepino-indole structure is a new inhibitor of M. tuberculosis growth in vitro.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ekaterina E. Khramtsova, Ekaterina A. Lystsova, Evgeniya V. Khokhlova, Maksim V. Dmitriev, Andrey N. Maslivets
Summary: The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is valuable in drug discovery, and replacing the 3-oxy fragment with a 3-amino one can significantly impact the biological effect of compounds. Developing approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones is of significant interest, and a new approach involving thermal decomposition of urea derivatives was successfully developed in this study.
Article
Chemistry, Multidisciplinary
Xuetong Li, Jordi Benet-Buchholz, Eduardo C. Escudero-Adan, Arjan W. Kleij
Summary: A conceptually novel catalytic domino approach is presented for the synthesis of highly functional 1,4-dihydro-2H-1,3-benzoxazine-2-one derivatives. The chemoselectivity is achieved through a proper design of the precursor and the use of Thorpe-Ingold effects. The synthetic diversity of these CO2-based heterocycles is demonstrated, and an unusual ring-expansion sequence is observed from an alpha-alkylidene, five-membered cyclic carbonate to a six-membered cyclic carbamate by N-induced isomerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Ryan M. Alam, John J. Keating
Summary: In this article, a novel strategy for the construction of the dihydropyrrolo[3,4-b]indol-(2H)-one (DHPI) core from 3-iodo-1H-indolyl substrates is described. The DHPI core is present in small molecule derivatives with a wide range of biological activities and has great pharmaceutical potential. Through an unprecedented Pd-catalyzed intramolecular aminocarbonylative ring closure, DHPI derivatives with diverse substitutions were synthesized in up to 90% isolated yield, demonstrating the compatibility of the optimized protocol with various functional groups.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Zhengjie Le, Yiwen Zhu, Zhi-Peng Bao, Jun Ying, Xiao-Feng Wu
Summary: A new palladium-catalyzed reaction has been developed for the efficient synthesis of 1,5-dihydro-2H-pyrrol-2-ones using benzene-1,3,5-triyl triformate as the CO source.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Medicinal
Bin Li, Mingli Hu, Chen Chen, Honglu Yin, Yan Deng, Haibo Li, Jing Zhang, Ling He
Summary: A series of novel compounds were synthesized using a new reaction methodology and their anticancer activity was evaluated. The results showed that compounds 2d and 2k exhibited potent inhibitory activity against various cancer cell lines with low toxicity to normal cells. Furthermore, compound 2d was found to arrest cancer cells in the cell cycle and induce apoptosis through multiple pathways.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
V. B. R. Krishnan, Santha Kumari Merugu, Siva Jyothsna Gali, Ravikumar Kapavarapu, Hari Babu Bollikolla
Summary: In the presence of imidazole hydrochloride, an efficient one-pot three-component synthesis of dihydropyrimidines was developed with good yields. Most of the synthesized compounds showed moderate to good anti-cancer activity.
Article
Chemistry, Physical
Antonia Iazzetti, Antonio Arcadi, Stefano Dessalvi, Giancarlo Fabrizi, Antonella Goggiamani, Federico Marrone, Andrea Serraiocco, Alessio Sferrazza, Karim Ullah
Summary: This study describes a straightforward assembly method for polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives, with a focus on exploring the impact of the features of the 1,3-dicarbonyls on the reaction outcome. The use of 2-methylcyclohexan-1,3-dione as the dicarbonyl source enables challenging functionalizations of the indole nucleus.
Article
Oncology
Nishtha Shalmali, Sandhya Bawa, Md Rahmat Ali, Sourav Kalra, Raj Kumar, Bushra Zeya, Moshahid Alam Rizvi, Sangh Partap, Asif Husain
Summary: This study aimed to investigate the anticancer potential of isatin-containing compounds and their kinase inhibition activity. A series of arylthiazole linked 2H-indol-2-one derivatives were synthesized and evaluated for their anticancer and kinase inhibition activity. Two compounds, 5a and 5g, showed significant inhibition against a panel of 60 cancer cell lines and demonstrated promising VEGFR-2 inhibitory activity. These compounds also exhibited good inhibitory activity against colorectal adenocarcinoma cells and induced cell cycle arrest at the G(2)/M phase, promoting apoptotic cell death.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Hamidreza Younesi, Sakineh Asghari, Ghasem Firouzzadeh Pasha, Mahmood Tajbakhsh
Summary: In this study, a multi-component reaction was used to modify the surface of nano zeolite, resulting in high functionality. The Ugi reaction was applied for the first time to develop a hydrogen-bonding nanocatalyst by post-modifying nano NaY zeolite with 3-aminopropyltriethoxysilane (APTES) and then reacting it with salicylaldehyde, tert-butyl isocyanide, and acetic acid. The modified nano zeolite showed improved reactivity, dispersibility, and hydrogen bonding formation capability. The nanocatalyst was characterized using various techniques and exhibited excellent catalytic activity in a three-component reaction. The catalyst could be easily separated and reused multiple times without significant activity loss, making this eco-friendly method suitable for the preparation of other important heterocyclic compounds.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nicolai A. Aksenov, Dmitrii A. Aksenov, Igor A. Kurenkov, Alexander Aksenov, Anton A. Skomorokhov, Lidiya A. Prityko, Michael Rubin
Summary: This new preparative method allows for the rapid assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from readily available synthetic precursors, which could not be prepared using previously known protocols.
Article
Chemistry, Multidisciplinary
Tarunkumar Nanjibhai Akhaja, Jignesh Priyakant Raval
CHINESE CHEMICAL LETTERS
(2012)
Article
Engineering, Chemical
Jignesh P. Raval, Deep R. Naik, Pradip S. Patel
Article
Chemistry, Medicinal
Tarunkumar Nanjibhai Akhaja, Jignesh Priyakant Raval
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Chemistry, Medicinal
Jignesh Priyakant Raval, Nilesh Hasmukhbhai Patel, Hemul Vinubhai Patel, Pradip Shantibhai Patel
MEDICINAL CHEMISTRY RESEARCH
(2011)
Article
Chemistry, Medicinal
Kruti Navin Myangar, Jignesh Priyakant Raval
MEDICINAL CHEMISTRY RESEARCH
(2012)
Article
Chemistry, Medicinal
Tarunkumar Nanjibhai Akhaja, Jignesh Priyakant Raval
MEDICINAL CHEMISTRY RESEARCH
(2013)
Article
Chemistry, Organic
Manishkumar B. Patel, Nishith R. Modi, Jignesh P. Raval, Shobhana K. Menon
ORGANIC & BIOMOLECULAR CHEMISTRY
(2012)
Article
Chemistry, Inorganic & Nuclear
Jignesh P. Raval, Bhanvesh N. Naik, Kishor R. Desai
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2012)
Article
Chemistry, Multidisciplinary
Jignesh P. Raval, Hemul V. Patel, Pradip S. Patel, Kishor R. Desai
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2010)
Article
Chemistry, Multidisciplinary
Jignesh P. Raval, Krunal G. Desai, Kishor R. Desai
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2012)
Article
Chemistry, Multidisciplinary
Jignesh P. Raval, Tarunkumar N. Akhaja, Dhaval M. Jaspara, Kruti N. Myangar, Nilesh H. Patel
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2014)
Article
Chemistry, Multidisciplinary
K. G. Desai, J. P. Raval, K. R. Desai
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2006)
Article
Chemistry, Multidisciplinary
Jignesh P. Raval, Kishor R. Desai
Article
Chemistry, Organic
Jignesh P. Raval, Jignasu T. Desai, Chintan K. Desai, Kishor R. Desai
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)