Glycerol mediated synthesis of 5-substituted 1H-tetrazole under catalyst free conditions

We have developed simple, cost effective and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazoles via [2,3] cycloaddition reaction from organic nitriles and sodium azide in glycerol under catalyst free condition. The corresponding 5-substituted 1H-tetrazoles were obtained with good to excellent yields (68-95%). (C) 2011 Sidhanath V. Bhosale. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.