Gindarudine, a novel morphine alkaloid from Stephania glabra

A novel morphine alkaloid, named gindarudine 1 has been isolated from ethanol extract of Stephania glabra tubers, together with four known alkaloids, palmatine, dehydrocorydalmine, stepharanine, and 8-(4'-methoxybenzyl)-xylopinine. Compound 1 was elucidated as 3,6-O,N-detrimethyl-10-hydroxy-1-methoxy-thebaine by means of spectroscopic data including 2D NMR studies. (C) 2009 Deepak Kumar Semwal. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.