Article
Chemistry, Medicinal
Laura Braconi, Silvia Dei, Marialessandra Contino, Chiara Riganti, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Maria Grazia Perrone, Nicola Antonio Colabufo, Stefano Guglielmo, Elisabetta Teodori
Summary: New 2,5- and 1,5-disubstituted tetrazoles, and 2,5-disubstituted-1,3,4-oxadiazoles were synthesized and studied as MDR reversers, showing potent inhibitory effects on P-gp transport activity and increasing the antiproliferative effect of doxorubicin in MDR cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Infectious Diseases
Dana Holger, Razieh Kebriaei, Taylor Morrisette, Katherine Lev, Jose Alexander, Michael Rybak
Summary: Pseudomonas aeruginosa is a common pathogen causing healthcare-associated diseases and is highly resistant to many antibiotics, posing challenges in treatment. Bacteriophages, as viruses targeting and infecting bacterial cells, offer promise as an alternative therapy for multidrug-resistant P. aeruginosa infections. Further studies on phage pharmacokinetics and pharmacodynamics are needed to guide successful phage therapy for these infections.
Article
Chemistry, Medicinal
Danica R. Cullen, Ashlee Gallagher, Caitlin L. Duncan, Jutharat Pengon, Roonglawan Rattanajak, Jason Chaplin, Hendra Gunosewoyo, Sumalee Kamchonwongpaisan, Alan Payne, Mauro Mocerino
Summary: This study reports the synthesis and antitrypanosomal activity of 80 compounds based on a core tetrahydroisoquinoline scaffold, revealing five derivatives with inhibition of T. b. rhodesiense growth in the sub-micromolar range. Four of these derivatives show good selectivity over mammalian cells and are predicted to have good absorption and metabolic stability, with the ability to permeate the blood brain barrier, making them promising candidates for antitrypanosomal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tingting Zou, Cheng Zeng, Junyan Qu, Xiaohua Yan, Zhenghong Lin
Summary: The study reveals that rutaecarpine can reverse ABCB1-mediated multidrug resistance by promoting the degradation of ABCB1 protein through increasing the protein level of MARCH8. This approach of co-administering rutaecarpine with conventional chemotherapeutic agents shows therapeutic effects on transplanted tumors.
Article
Infectious Diseases
Kamonwan Lunha, Wiyada Chumpol, Sukuma Samngamnim, Surasak Jiemsup, Pornchalit Assavacheep, Suganya Yongkiettrakul
Summary: Streptococcus suis is a pathogen that causes severe infections in humans and pigs. Antibiotic resistance is a global problem, and monitoring of antibiotic-resistant S. suis is essential. This study investigated the antimicrobial susceptibility of S. suis strains isolated from diseased pigs in Thailand and found widespread multidrug resistance in different serotypes, time periods, and regions.
Article
Biochemistry & Molecular Biology
Gao-Jie Ye, Chao-Yun Cai, Zhuo-Xun Wu, Qiu-Xu Teng, Jing-Quan Wang, Zhe-Sheng Chen, Bo Wang
Summary: Three series of phenylurea indole derivatives were synthesized with potent inhibitory activities on ABCG2. Four phenylurea indole derivatives with extended 7C system showed the most potent ABCG2 inhibition and no inhibition on ABCB1. Further investigation on two compounds revealed that they increased the accumulation of mitoxantrone in ABCG2-overexpressing cells and stimulated the ATP hydrolysis of ABCG2 transporter.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chunyu Jiang, Ting Pan, Yunxiang Jiang, Zhiyu Zhang, Meifeng Zeng, Shuang Sun, Zheng Li, Yiqing Wu, Jingying Qiu, Mingshan Niu, Xiaoke Gu
Summary: In this study, fourteen novel dibenzoazepine-tetrahydroisoquinoline hybrids were synthesized as potential P-gp inhibitors to overcome multidrug resistance caused by P-gp. Among them, 8a showed the strongest inhibitory effect on P-gp, effectively reversing P-gp-mediated drug resistance. Further investigation revealed that 8a improved the stability of P-gp by impairing its function without affecting its expression. These findings suggest that 8a may be a promising lead compound for designing P-gp inhibitors to overcome multidrug resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mohamed H. Saad, Tarek F. El-Moselhy, S. El-Din Nabaweya, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik, Mervat H. El-Hamamsy
Summary: Two series of 1,4-DHP derivatives, symmetric (1a-h) and asymmetric (2a-l), were designed, synthesized, and evaluated for their anticancer and antimicrobial activities. Compounds 1g, 2e, and 2l showed significant anticancer activity with potential mechanisms involving reversal of doxorubicin effects and inhibition of specific biological targets.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Farooq-Ahmad Khan, Sana Yaqoob, Shujaat Ali, Nimra Tanveer, Yan Wang, Sajda Ashraf, Khwaja Ali Hasan, Shaden A. M. Khalifa, Qiyang Shou, Zaheer Ul-Haq, Zi-Hua Jiang, Hesham R. El-Seedi
Summary: We report the antimicrobial effect of functionally substituted pyridine carbohydrazide on multidrug-resistant strains. Compound 6 exhibited potent activity against Candida spp. strains with remarkable inhibition. Compound 4 demonstrated significant antibacterial effect against Pseudomonas aeruginosa. These compounds have the potential to be promising antimicrobial drugs against multidrug-resistant strains.
Review
Oncology
Muhammad Muzamil Khan, Vladimir P. Torchilin
Summary: Chemotherapy for cancer often leads to poor treatment response due to tumor resistance. To overcome this challenge and improve therapeutic efficacy, novel nanoparticle-based strategies are being developed. These strategies include the use of nanoparticles/liposomes for drug and siRNA delivery to downregulate resistance-causing genes, as well as the use of natural substances like chemosensitizers to enhance response to therapy.
Article
Biochemistry & Molecular Biology
Matthew Payne, Amy L. L. Bottomley, Anthony Och, Hugh G. G. Hiscocks, Anjar P. P. Asmara, Elizabeth J. J. Harry, Alison T. T. Ung
Summary: Antibiotic resistance poses a major threat to modern medicine, driving the need for novel antibiotics with low resistance potential. A study on the synthesis of 18 novel compounds revealed one molecule with potent antibacterial activity against S. aureus and M. tuberculosis without observed resistance. Further development of this molecule and its analogues could be promising in addressing antibiotic resistance.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Erin J. Pratt, Elena I. Mancera-Andrade, Kevin L. Bicker
Summary: Cryptococcal meningitis is a devastating disease with high mortality. This study aimed to optimize an antifungal peptoid and improve its biological properties. While no dramatic improvement was achieved, this study is an important step in the development of a viable antifungal therapeutic.
Article
Microbiology
Xiuzhen Zhou, Jianhua Liu, Zhijie Zhang, Bing Cui, Yanling Wang, Yue Zhang, Hailin Xu, Guixue Cheng, Yong Liu, Xiaosong Qin
Summary: This study presents a retrospective analysis using 1,240 clinical erythromycin-resistant Streptococcus pneumoniae (ERSP) isolates collected in northeastern China between January 2000 and December 2019. The serotype distribution, corresponding vaccine coverage, as well as resistance phenotypes, genes, and mechanisms to macrolide and tetracycline of these isolates were systematically described, analyzed, and discussed.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biotechnology & Applied Microbiology
Zhenlong Wang, Na Yang, Da Teng, Ya Hao, Ting Li, Huihui Han, Ruoyu Mao, Jianhua Wang
Summary: This study identified the resistance mechanisms of E. coli to the antimicrobial peptide N6NH(2) as increased biofilm formation capacity, decreased affinity with lipopolysaccharide (LPS), and changed cell membrane permeability and potential. Additionally, a chimeric peptide called G6 showed stronger inhibition against N6NH(2)-resistant mutants through enhanced biofilm formation inhibition, increased affinity with LPS, and greater membrane permeability and depolarization compared to N6NH(2).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Nelson E. Masota, Knut Ohlsen, Lorenz Meinel, Ulrike Holzgrabe
Summary: The ongoing threat of antimicrobial resistance and multidrug-resistant pathogens calls for increased efforts in the search for novel treatment options. This study synthesized a series of gluco-vanillin derivatives and found that compounds containing 2,4- and 3,5-dichlorophenylamino group coupled to a glucovanillin moiety exhibited optimum antibacterial activities. These derivatives showed moderate and broad-spectrum activities against reference and multidrug-resistant strains.
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)