Article
Chemistry, Medicinal
Adelaide Cupo, Simone Landi, Salvatore Morra, Genoveffa Nuzzo, Carmela Gallo, Emiliano Manzo, Angelo Fontana, Giuliana D'Ippolito
Summary: This study investigates the cultivation of marine diatom Cyclotella cryptica under different growth conditions, finding that heterotrophic growth leads to higher EPA production, productivity, and potential for biotechnological exploitation.
Article
Biochemistry & Molecular Biology
Yandan Wang, Minjie Cao, Ruijie Liu, Ming Chang, Wei Wei, Qingzhe Jin, Xingguo Wang
Summary: The study synthesized EPA-rich medium- and long-chain triacylglycerol (MLCT) with significant changes in TAG profiles. During digestion, MLCT showed higher hydrolysis and release of free fatty acids compared to other oils. The composition and positional distribution of fatty acids in MLCT were beneficial for absorption and transport, potentially maximizing nutritional value.
Review
Nutrition & Dietetics
Maja Tomczyk, Jeffery L. Heileson, Miroslaw Babiarz, Philip C. Calder
Summary: Fatty fish and certain species of algae are the only natural sources of EPA and DHA, which have various beneficial effects for athletes. Due to limited intake and fluctuating content, athletes may consider using supplements to ensure sufficient EPA and DHA levels.
Article
Fisheries
Sam J. S. Houston, Vasileios Karalazos, John Tinsley, Douglas R. Tocher, Brett D. Glencross, Oscar Monroig
Summary: Carnivorous marine fish species such as gilthead seabream require dietary EPA and DHA acids for optimal growth. However, the limited supply of marine oils in aquafeeds due to the rapid growth of global aquaculture has led to the use of vegetable oils lacking EPA and DHA. Therefore, the EFA requirements of juvenile marine fish need to be reassessed. A dietary trial with gilthead seabream demonstrated that the EFA requirement is a function of fish mass, decreasing as the fish grows, and may be as high as 2% when considering feed conversion ratio. Different regression models were explored to determine nutrient requirement estimates, with the split linear model fitting the data best for both pellet sizes.
Article
Multidisciplinary Sciences
Kristin J. Skaarud, Johannes R. Hov, Simen H. Hansen, Martin Kummen, Jorgen Valeur, Ingebjorg Seljeflot, Asta Bye, Vemund Paulsen, Knut E. A. Lundin, Marius Troseid, Geir E. Tjonnfjord, Per Ole Iversen
Summary: After allo-HSCT, gut microbiota and short-chain fatty acids were significantly reduced, with no significant differences between the intervention group and controls in investigated parameters. Patients with low microbial diversity at 3 weeks post-HSCT had significantly higher mortality rates, while those with higher abundance of Blautia genus were more likely to survive.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Subodh Verma, Deepak L. Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Nitish K. Dhingra, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, C. Michael Gibson, Duane Pinto, Robert P. Giugliano, Matthew J. Budoff, R. Preston Mason, Jean-Claude Tardif, Christie M. Ballantyne
Summary: In patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl in the REDUCE-IT trial led to significant reductions in both first and recurrent ischemic events compared to placebo, with similar safety findings between groups.
Review
Cardiac & Cardiovascular Systems
Michelle D. Kelsey, Neha J. Pagidipati
Summary: There has been much debate surrounding the use of omega-3 fatty acids, EPA and DHA, for cardiovascular risk reduction. Recent trials have offered conflicting evidence, with some showing reduction in CV risk using EPA alone in select populations, while others demonstrate no benefit and potential side effects.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Jisun So, Bela F. Asztalos, Katalin Horvath, Stefania Lamon-Fava
Summary: The study aimed to evaluate the common and differential effects of EPA and DHA on plasma lipids and lipoproteins and to assess the metabolic mechanisms of these effects. The results showed that EPA and DHA had similar effects on plasma TG, but differences were observed in LDL-C concentrations and activities of some enzymes involved in lipoprotein metabolism. It was also noted that EPA and DHA worked differently in men and women.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Fang, Zhuangwei Zhang, Yinyin Cheng, Haitao Yang, Hui Zhang, Zhe Xue, Songtao Lu, Yichen Dong, Chunyan Song, Xiaohong Zhang, Yuping Zhou
Summary: The study found that EPA and DHA have different effects in ulcerative colitis. High-dose EPA can enhance the mucus barrier, regulate the gut microbiome, and relieve inflammation. This suggests that EPA may be a promising adjunctive therapy for ulcerative colitis.
Article
Cardiac & Cardiovascular Systems
Arjun Majithia, Deepak L. Bhatt, Allon N. Friedman, Michael Miller, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, Matthew Budoff, R. Preston Mason, Jean-Claude Tardif, William E. Boden, Christie M. Ballantyne
Summary: In the REDUCE-IT trial, icosapent ethyl reduced fatal and nonfatal ischemic events across a broad range of baseline eGFR categories.
Article
Chemistry, Physical
Balaji Panchal, Yongjing Hao, Zhibin Han, Tao Chang, Zheng Zhu, Xionglei Wang, Shenjun Qin
Summary: In this study, fatty acid esters were efficiently synthesized using a reusable lipase immobilized with a novel porous ionic polymer. The immobilized lipase showed excellent catalytic activity and stability, making it a cost-effective and environmentally friendly catalyst for biodiesel production.
JOURNAL OF CATALYSIS
(2022)
Article
Food Science & Technology
Alejandra Valencia-Naranjo, Luz M. Manjarres-Correa, Juliana Bermudez-Cardona
Summary: This study aimed to evaluate the changes in the concentrations of EPA and DHA in the erythrocytes and breast milk of lactating women after three months of supplementation. The study found low consumption of omega-3 food sources and low EPA and DHA content initially. After supplementation, there was a significant increase in DHA levels in both erythrocytes and breast milk, while EPA levels did not change significantly.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Wenjia Gu, John M. M. Kavanagh, Dale D. D. McClure
Summary: There is an increasing demand for sustainable sources of omega-3 fatty acids, and microalgae can be used to produce eicosapentaenoic acid (EPA) on a large scale. The choice of suitable strains is crucial for successful production. However, findings from small-scale systems do not always translate to larger photobioreactors. In this study, the productivity and fatty acid composition of eleven microalgal strains were examined in both flask and photobioreactor cultures. The results showed that predictions based on flask screening were not accurate for photobioreactors, highlighting the need for improved screening tools. Among the species tested, Phaeodactylum tricornutum showed the most potential when grown in photobioreactors. The study also investigated the impact of environmental conditions (temperature and salinity) on EPA production and found that EPA content remained relatively constant within the tested temperature and salinity ranges. Finally, nutritional information about the biomass was provided, which can be used as a starting point for formulating food products.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Nutrition & Dietetics
Martin E. Reiner, Philipp Baumgartner, Andrea Wiencierz, Michael Coslovsky, Nicole R. Bonetti, Mark G. Filipovic, Giulia Montrasio, Stefanie Aeschbacher, Nicolas Rodondi, Oliver Baretella, Michael Kuehne, Giorgio Moschovitis, Pascal Meyre, Leo H. Bonati, Thomas F. Luescher, Giovanni G. Camici, Stefan Osswald, David Conen, Juerg H. Beer
Summary: The study showed that EPA and DPA were associated with large noncortical or cortical infarcts (LNCCIs) in patients with atrial fibrillation, with EPA negatively correlated and DPA positively correlated with LNCCIs. However, there was no significant correlation between EPA and DPA with markers of small vessel disease in atrial fibrillation patients.
Article
Biotechnology & Applied Microbiology
Myroslav Sprynskyy, Fernanda Monedeiro, Maciej Monedeiro-Milanowski, Zuzanna Nowak, Aneta Krakowska-Sieprawska, Pawel Pomastowski, Renata Gadzala-Kopciuch, Boguslaw Buszewski
Summary: This study aimed to isolate EPA and DHA from diatom biomass using different extraction methods and analyze the extracts. Reflux extraction yielded the highest content of omega-3 fatty acids, while the extracts obtained from SFE had lower toxicity and could be directly used for product development.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Education & Educational Research
Jarkko Hautala, Stefan Hawelka, Mikko Aro
Summary: The study found that in 9-10 year old children with reading difficulties, early word frequency effect appeared in first fixation duration, followed by word length effect and the interaction of word frequency and word length. Poor reading fluency was mainly explained by inflated first fixation durations, and stronger word frequency and length effects in summed refixation duration.
READING AND WRITING
(2022)
Article
Education & Educational Research
Priyanka Patel, Minna Torppa, Mikko Aro, Ulla Richardson, Heikki Lyytinen
Summary: The study found that using GraphoLearn (GL) English Rime, a computer-assisted reading intervention, improved the foundational literacy skills of 1st and 2nd grade students in India, especially those with stronger English literacy skills. However, the intervention did not show effects on out-of-game English literacy tasks, opening up further discussion on successful implementation of such interventions.
JOURNAL OF COMPUTER ASSISTED LEARNING
(2022)
Article
Education, Special
Minna Kyttala, Piia Maria Bjorn, Milla Rantamaki, Vesa Narhi, Mikko Aro
Summary: This survey study examines the interrelationships between assessment conceptions, assessment self-efficacy, prior education, and teaching experience among Finnish pre-service special educational needs teachers. The results indicate that assessment conceptions and assessment self-efficacy are intertwined.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2023)
Article
Education, Special
Maris Juhkam, Piret Soodla, Mikko Aro
Summary: This study aims to investigate the accuracy of Estonian teachers' and support specialists' judgements of students' spelling skills and reading fluency, and to explore the influence of special education services on teachers' judgements. The results show that the judgements of reading fluency are less accurate compared to those of spelling skills. Moreover, the provision of special education services affects teachers' judgements, leading them to identify students in need of help even if they were not initially assigned to the low-skilled group. Unexpectedly, teachers' judgements of students receiving special education services were slightly more accurate than those of support specialists.
Article
Clinical Neurology
Liisa Klenberg, Sini Teivaanmaki, Vesa Narhi, Noona Kiuru, Dione Healey
Summary: The play-based ENGAGE intervention effectively improved behavioral outcomes related to executive functions in preschool-age children with hyperactivity and/or inattention problems. Parents reported significant decreases in attentional problems, hyperactivity/impulsivity, and acting out behaviors. However, teacher ratings did not consistently show improvement in executive function difficulties.
CHILD NEUROPSYCHOLOGY
(2023)
Article
Education & Educational Research
Lisa Hintermeier, Jarkko Hautala, Mikko Aro
Summary: This study examined the influence of syllable number on word recognition in developing readers of Finnish language, while controlling for word length and frequency, and determined whether this effect is dependent on reading fluency. Eye movements of 142 third and fourth graders were recorded during silent reading of two stories, and reading fluency was separately assessed. The results showed a significant effect of syllable number on first fixation duration but not on later reading measures, and this effect was consistent in both fluent and dysfluent readers.
SCIENTIFIC STUDIES OF READING
(2023)
Article
Education, Special
Iines R. Palmu, Sami J. Maatta, Vesa M. Narhi, Hannu K. Savolainen
Summary: This longitudinal study investigated the longitudinal relationships of ADHD symptoms, school adjustment and academic performance during the transition from primary to middle school in a Finnish sample. The findings revealed gender differences in the mechanisms, where ADHD symptoms indirectly impacted academic performance through maladaptive achievement strategies for boys, while directly affecting Grade 7 academic performance for girls. Moreover, ADHD symptoms were only associated with SES and pedagogical support among boys.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2023)
Article
Education, Special
Noora Heiskanen, Anne Karhu, Hannu Savolainen, Vesa Naerhi
Summary: The effective implementation of PBIS requires both organisational and professional change, with the whole community committing to shared principles, practices, and structures. This study examines the initial implementation of PBIS ProVaka in Finnish ECEC centres, focusing on roles, responsibilities, and communication. The results show that successful development depends on expanding the actor network and shared responsibility, while challenges include knowledge base equality, concrete implementation, balancing theoretical validity with cultural adaptation, regulation of motivation and enthusiasm, constant need for change, and clashes with everyday life realities.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2023)
Article
Education, Special
Jukka Sivola, Vesa Narhi, Asko Tolvanen, Tuomo Virtanen, Hannu Savolainen
Summary: The outcomes of studies on the effectiveness of special education (SE) are still unclear, with only a few studies using advanced methodology to minimize selection bias. This study used a quasi-experimental method of propensity score matching to examine the effects of SE on students' affective and motivational outcomes. The results showed that SE did not have any effects on students' affective or motivational outcomes when comparing matched groups of students.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2023)
Article
Psychology, Educational
R. Palmu Iines, J. Maatta Sami, M. Naerhi Vesa, K. Savolainen Hannu
Summary: This longitudinal study investigated the relationship between externalizing behavior problems (ADHD and CDs), motivation (MAS), and academic performance over time. The findings revealed reciprocal effects between ADHD symptoms and MAS in Grades 5 and 6, as well as negative predictions for later academic performance in both domains. While no cross-lagged effects were found between CDs and MAS, both were positively correlated and had negative impacts on subsequent academic performance. These results highlight the different interactions of externalizing problems with students' motivation and academic performance in the long term, with ADHD symptoms being more detrimental than CDs.
EMOTIONAL AND BEHAVIOURAL DIFFICULTIES
(2023)
Article
Education & Educational Research
Mika Paananen, Tuija Aro, Tuire Koponen, Helena Viholainen, Asko Tolvanen, Pilvi Peura, Mikko Aro
Summary: This study investigated variations in the sources of self-regulatory efficacy (SRE) among elementary school children and how these variations were related to SRE, reading skills, and arithmetic skills. The results showed that mastery experiences and emotional states were the most sensitive sources for detecting interindividual differences. Multiple positive sources contributed to higher SRE, while low exposure to sources was related to lower SRE and low basic academic skills.
EDUCATIONAL PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Riikka Sorvo, Noona Kiuru, Tuire Koponen, Tuija Aro, Helena Viholainen, Timo Ahonen, Mikko Aro
Summary: Studies have found a relationship between math anxiety and achievement, with anxiety having both a long-term effect and a situational association with performance.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Education, Special
Minna Kyttala, Piia Maria Bjorn, Milla Rantamaki, Vesa Narhi, Mikko Aro
Summary: This study aimed to investigate how Finnish pre-service special needs teachers’ assessment conceptions, prior academic studies, and teaching experience cluster into different patterns representing different student types. Three main factors of assessment conceptions were identified: assessment measures learning, assessment supports teaching and learning, and assessment as a harmful action. These factors were emphasized differently in each pattern. Assessment conceptions, prior studies, and teaching experience were clustered in three patterns: Assessment Criticals, Assessment Positives, and Assessment Cautious, showing different starting points for professional growth during studies.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2022)
Article
Education & Educational Research
Riitta Virinkoski, Marja-Kristiina Lerkkanen, Kenneth Eklund, Mikko Aro
Summary: This study examined the assessment practices of SEN teachers and the accuracy of their ratings in reading fluency and comprehension. The results showed that teachers relied mostly on observations in their assessments and there was a moderate correlation between their ratings and test scores in fluency, but a weak correlation in comprehension. Furthermore, identification of low-performing students and students with typical reading comprehension was inaccurate.
SCANDINAVIAN JOURNAL OF EDUCATIONAL RESEARCH
(2022)
