期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 38, 页码 11107-11111出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504687
关键词
furans; hypervalent iodine compounds; imines; multicomponent reactions; palladium
资金
- Singapore National Research Foundation [NRF-RF2009-05]
- Nanyang Technological University
Mild and regiocontrolled synthesis of a multisubstituted furan is achieved through Pd(OAc)(2)-catalyzed room-temperature condensation of an alkynylbenziodoxole, a carboxylic acid, and an enolizable ketimine, which contribute to C1, CO, and C2 fragments, respectively, to the furan skeleton. The reaction tolerates a broad range of functional groups in each of the reaction components, and enables highly modular and flexible synthesis of variously substituted furans. The reaction is particularly effective for the rapid generation of tri-and tetraarylfurans and furan-containing oligoarylenes without relying on conventional cross-coupling chemistry.
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