Article
Critical Care Medicine
Jarrod E. Dalton, Paul R. Gunsalus, Carli J. Lehr, Johnie Rose, Belinda L. Udeh, Maryam Valapour
Summary: The current U.S. lung transplant mortality risk models do not consider the disease progression of patients over time. This study investigated the impact of accrued waitlist time on mortality in lung transplant candidates and recipients beyond clinical deterioration and proposed a new framework for conceptualizing mortality risk in end-stage lung disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kristen T. Carter, Robert O'Brien, Sharon B. Larson, Lawrence L. Creswell, Matthew Kutcher, David A. Baran, Jack G. Copeland, Hannah Copeland
Summary: This retrospective study on heart transplant recipients found that patients bridged to heart transplant with venoarterial extracorporeal membrane oxygenation had lower survival rates. Recipients requiring different forms of mechanical support had relatively longer survival times, emphasizing the importance of careful monitoring for patients on extracorporeal membrane oxygenation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Rachel L. Deitz, Leonid Emerel, Ernest G. Chan, John P. Ryan, Eric Hyzny, Masashi Furukawa, Pablo G. Sanchez
Summary: This study investigated variables associated with mortality on the waiting list for lung transplant in patients supported on extracorporeal membrane oxygenation (ECMO). The results showed that patients at high-risk centers were more likely to survive to transplantation. This suggests that ECMO is an appropriate strategy to bridge high-risk patients to lung transplant.
ANNALS OF THORACIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Dong Kyu Oh, Sang-Bum Hong, Tae Sun Shim, Dong Kwan Kim, Sehoon Choi, Geun Dong Lee, Won Kim, Seung-Il Park
Summary: Despite the severity of illness, patients in the bridge to lung transplantation (BTT) group showed favorable post-transplant outcomes, particularly those who were bridged for less than 14 days. Long-term BTT was an independent risk factor for 1-year post-transplant mortality, while short-term BTT was not.
Article
Management
Joris van de Klundert, Liana van der Hagen, Aniek Markus
Summary: In the last three decades, inequities in waiting times for deceased donor organ transplantation, particularly kidney transplantation in the United States, have been addressed through formal modeling, analysis, and optimization using queuing models, network flows, and Rawls' Theory of Justice. By considering blood type incompatibilities and ethnic differences, the research has shown that current allocation policies can effectively reduce inequities in waiting time and transplant probability related to blood types.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jay M. Brahmbhatt, Travis Hee Wai, Christopher H. Goss, Erika D. Lease, Christian A. Merlo, Siddhartha G. Kapnadak, Kathleen J. Ramos
Summary: Improved predictive models are needed for lung transplantation in the United States to accurately predict long-term post-transplant survival and fairly allocate organs. The existing models show poor accuracy in predicting 1-year and 3-year post-transplant mortality, and tend to overestimate the risk of death in patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Surgery
Liise K. Kayler, Jing Nie, Katia Noyes
Summary: The study found that the hardest-to-place kidneys accepted later in the match run were associated with higher rates of delayed graft function and graft failure.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yoshito Yamada, Tosiya Sato, Norio Harada, Hidenao Kayawake, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Hiroshi Date
Summary: This study found that perioperative diabetes mellitus is an independent adverse factor for overall survival and CLAD-free survival after lung transplantation, with diabetic patients having lower survival rates and CLAD-free survival rates compared to non-diabetic patients at the 6-month landmark point post-transplantation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshito Yamada, Tosiya Sato, Norio Harada, Hidenao Kayawake, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Hiroshi Date
Summary: The study found that perioperative diabetes mellitus (DM) is an independent adverse factor for overall survival (OS) and CLAD-free survival after lung transplantation. The management of perioperative DM should be emphasized in clinical practice.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Bob Z. Sun, Aaron Wightman, Douglas S. Diekema
Summary: This article examines ethical considerations of mandating COVID-19 vaccination for primary caregivers of solid organ transplant candidates. It highlights the potential improvement in overall utility in organ allocation and the need for sensitivity to the changing circumstances of disease severity, transmissibility, and vaccine effectiveness.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Darren Stewart, Tatenda Mupfudze, David Klassen
Summary: We estimated the median waiting time for kidney transplant in the United States using different methods and timeframes. The overall median waiting time decreased to 5.19 years between 2015 and 2018 and further declined to 4.05 years from April 2021 to March 2022. There were significant differences in median waiting times based on blood type, donor service area, and pediatric vs adult status, but less variation by race/ethnicity. We recommend using the period-prevalent Kaplan-Meier approach in addition to the competing risks approach to address the lack of information on kidney transplant waiting times.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
David Furfaro, Erika B. Rosenzweig, Lori Shah, Hilary Robbins, Michaela Anderson, Hanyoung Kim, Darryl Abrams, Cara L. Agerstrand, Daniel Brodie, Danielle Feldhaus, Joseph Costa, Philippe Lemaitre, Bryan P. Stanifer, Frank D'Ovidio, Joshua R. Sonett, Selim Arcasoy, Luke Benvenuto
Summary: In patients bridging to transplant on ECMO, those with PAH had a lower transplantation rate compared to patients with other conditions like OLD, CF, and ILD.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas R. Hess, Gavin W. Hickey, Ibrahim Sultan, Arman Kilic
Summary: The recent change in heart allocation policy has led to shorter waitlist times and increased likelihood of heart transplant for patients bridged with ECMO. Posttransplant 1-year survival remains comparable, although there is a slight decrease in absolute rates.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Multidisciplinary Sciences
Jong Cheol Jeong, Tai Yeon Koo, Han Ro, Dong Ryeol Lee, Dong Won Lee, Jieun Oh, Jayoun Kim, Dong-Wan Chae, Young Hoon Kim, Kyu Ha Huh, Jae Berm Park, Yeong Hoon Kim, Seungyeup Han, Soo Jin Na Choi, Sik Lee, Sang-Il Min, Jongwon Ha, Myoung Soo Kim, Curie Ahn, Jaeseok Yang
Summary: Data for Asian kidney transplants are limited. This study investigated the prognostic markers in Asian kidney transplants using the Korean Organ Transplantation Registry cohort. Prediction models were developed and the relative importance of selected predictors was measured. The study identified the dominant predictors for recipient mortality, death-censored graft loss, and acute rejection within one year.
SCIENTIFIC REPORTS
(2022)
Review
Critical Care Medicine
John W. Stokes, Whitney D. Gannon, Matthew Bacchetta
Summary: ECMO-BTLT has recently shown success in preserving patients' physiologic condition and candidacy prior to lung transplant, due to technological advances and improved management practices. Further studies are needed to refine practice patterns, management strategies, and lung allocation for this high-risk patient population.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Guerrera, Pierre Emmanuel Falcoz, Bernhard Moser, Dirk van Raemdonck, Andrea Bille', Alper Toker, Lorenzo Spaggiari, Luca Ampollini, Claudia Filippini, Pascal Alexandre Thomas, Bram Verdonck, Paolo Mendogni, Clemens Aigner, Luca Voltolini, Nuria Novoa, Miriam Patella, Sara Mantovani, Ivan Gomes Bravio, Charalambos Zisis, Angela Guirao, Francesco Londero, Miguel Congregado, Gaetano Rocco, Bert Du Pont, Nicola Martucci, Matthias Esch, Alessandro Brunelli, Frank C. Detterbeck, Federico Venuta, Walter Weder, Enrico Ruffini, Walter Klepetko, Anne Olland, Daisuke Nonaka, Berker Ozkan, Giorgio Lo Iacono, Cesare Braggio, Pier Luigi Filosso, Geoffrey Brioude, Paul van Schil, Mario Nosotti, Daniel Valdivia, Stefano Bongiolatti, Ilhan Inci, Rontogianni Dimitra, David Sanchez, William Grossi, Sergio Moreno-Merino, Martin Teschner
Summary: The study compared the short- and long-term outcomes of simple thymomectomy (ST) versus thymothymectomy (TT) in non-myasthenia gravis (MG) early-stage thymomas. The TT group had significantly better 5-year freedom from recurrence and 5-year overall survival rate compared to the ST group, without an increase in postoperative morbidity rate.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Editorial Material
Critical Care Medicine
Thomas Langer, Serena Brusatori, Luciano Gattinoni
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, John J. Marini
INTENSIVE CARE MEDICINE
(2022)
Letter
Respiratory System
Mattia Busana, Luigi Camporota, Luciano Gattinoni
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Critical Care Medicine
Luciano Gattinoni, Silvia Coppola, Luigi Camporota
INTENSIVE CARE MEDICINE
(2022)
Letter
Respiratory System
Mattia Busana, Luigi Camporota, Luciano Gattinoni
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Physiology
David C. Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, Paul Phillipp Heinisch, Hansjorg Jenni, Matthias Haenggi, Luciano Gattinoni, Kaspar F. Bachmann
Summary: Assessment of native cardiac output during extracorporeal circulation is challenging. This study evaluated a modified Fick principle for accurately measuring cardiac output under different conditions. The findings provide important insights for understanding veno-arterial extracorporeal membrane oxygenation (V-A ECMO).
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Anesthesiology
Simone Gattarello, Silvia Coppola, Elena Chiodaroli, Tommaso Pozzi, Luigi Camporota, Leif Saager, Davide Chiumello, Luciano Gattinoni
Summary: This study assessed lung mechanics in nonintubated patients with COVID-19 pneumonia and found that patients in the treatment escalation group had higher respiratory rate, tidal volume, and mechanical power ratio compared to the no-treatment escalation group. Mechanical power, its ratio, and pressure-rate index showed the highest association with the clinical outcome.
Editorial Material
Anesthesiology
Simone Gattarello, Luigi Camporota, Luciano Gattinoni
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Letter
Critical Care Medicine
Tommaso Pozzi, Francesca Collino, Serena Brusatori, Federica Romitti, Mattia Busana, Onnen Moerer, Luigi Camporota, Davide Chiumello, Silvia Coppola, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Serena Brusatori, Carmelo Zinnato, Tommaso Pozzi, Luigi Camporota, John J. Marini, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Francesca Collino, Luigi Camporota
INTENSIVE CARE MEDICINE
(2023)
Article
Physiology
Rosanna D'Albo, Federica Romitti, Luigi Camporota, Onnen Moerer, Mattia Busana, Luciano Gattinoni
Summary: The conditions of temperature, pressure, and saturation in which respiratory gas volumes are expressed are often ignored in clinical practice. This study investigates the effects of gas volume corrections on key respiratory and metabolic variables, and the possible clinical consequences. The findings suggest that gas volume corrections are mostly relevant when assessing CO2 clearance, and knowing when the appropriate corrections are needed allows for a better understanding of patients' clinical conditions and tailored treatment.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Giuseppe Citerio, Arthur S. Slutsky
INTENSIVE CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fabio Silvio Taccone, Simone Rinaldi, Filippo Annoni, Leda Nobile, Matteo Di Nardo, Jessica Maccieri, Anna Aliberti, Maximilan Valentin Malfertheiner, Andrea Marudi, Lars Mikael Broman, Mirko Belliato
Summary: This retrospective study examines the effectiveness and safety of a dedicated ECCO2R device in critically ill patients. The results show that the device is able to effectively remove carbon dioxide, improve gas exchange, and has few side effects.