Article
Clinical Neurology
Arie Oksenberg, Timo Leppanen
Summary: Several factors, including gender, age, body mass index, sleep stage, and sleeping position, influence the duration of respiratory events during sleep. Women tend to have shorter events compared to men, while older adults experience longer events. An increase in body mass index decreases the duration of respiratory events. Sleeping position, especially in the supine posture, also affects event duration.
SLEEP MEDICINE REVIEWS
(2023)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Arie Oksenberg, Timo Leppanen
Summary: Research on the duration of respiratory events in obstructive sleep apnea (OSA) has been limited, but recent studies have emphasized the importance of this overlooked parameter. Most studies suggest that longer respiratory events have more severe physiological and clinical consequences, likely due to higher hypoxic burden. However, some qualified studies show that even short respiratory events have deleterious effects on sleep and OSA. Therefore, the duration of respiratory events should be quantified in the diagnosis and assessment of OSA.
SLEEP MEDICINE REVIEWS
(2023)
Review
Andrology
Liang Su, Yu-Hang Meng, Si-Zheng Zhang, Yan Cao, Jian Zhu, Hua Qu, Yong-Zheng Jiao
Summary: This study found a significant inverse association between obstructive sleep apnea and male serum testosterone levels. After adjusting for age and body mass index, this inverse association still existed. The severity of obstructive sleep apnea is correlated with a significant reduction in male serum testosterone levels.
Article
Clinical Neurology
Jinling Du, Yijia Chen, Nan Zhou, Yingqian Song, Weiwei Wang, Xin Hong
Summary: There is a U-shaped correlation between sleep duration and abnormal serum lipid profiles, and both shorter and longer sleep durations are associated with abnormal serum lipids in both men and women.
Article
Biochemistry & Molecular Biology
Ante Mihovilovic, Zoran Dogas, Dinko Martinovic, Daria Tokic, Ema Puizina Mladinic, Marko Kumric, Natalija Ivkovic, Marino Vilovic, Josko Bozic
Summary: Obstructive sleep apnea (OSA) is a major public concern and this study aimed to evaluate serum Urotensin II (UII) levels in OSA patients and controls. The study included 89 OSA patients and 89 controls, and UII levels as well as other parameters were assessed. The OSA group had higher levels of hsCRP and serum UII compared to the control group, and there was a positive correlation between UII levels and hsCRP and systolic blood pressure. Multiple regression analysis showed significant associations of UII levels with AHI, SBP, and hsCRP. These findings suggest that UII may play a role in the complex pathophysiology of OSA and its cardiometabolic complications.
Article
Clinical Neurology
Sofia F. Furlan, Viktor Sinkunas, Lucas P. Damiani, Ronaldo B. Santos, Matheus Peres, Pedro A. Lemos, Chi-Hang Lee, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: This study aimed to explore the associations of obstructive sleep apnea (OSA) and sleep duration (SD) with renal function in subjects with coronary artery disease (CAD). The results showed that OSA severity and SD were not independently associated with chronic kidney disease (CKD) in CAD patients.
Article
Hematology
Silvana P. Souza, Ronaldo B. Santos, Itamar S. Santos, Barbara K. Parise, Soraya Giatti, Aline N. Aielo, Lorenna F. Cunha, Wagner A. Silva, Luiz A. Bortolotto, Geraldo Lorenzi-Filho, Paulo A. Lotufo, Isabela M. Bensenor, Luciano F. Drager
Summary: The study found that obstructive sleep apnea (OSA) is independently associated with a dose-response relationship with carotid intima-media thickness (CIMT), while sleep duration (SD) is not correlated with CIMT and does not interact with OSA to increase CIMT.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Computer Science, Information Systems
Henri Korkalainen, Timo Leppanen, Brett Duce, Samu Kainulainen, Juhani Aakko, Akseli Leino, Laura Kalevo, Isaac O. Afara, Sami Myllymaa, Juha Toyras
Summary: Analyzing sleep architecture with deep learning methods revealed highly fragmented sleep in severe OSA patients, potentially underestimated by traditional sleep staging. The study highlights the importance of detailed sleep analysis when assessing sleep disorders.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Clinical Neurology
Ariel A. Williamson, Jiaxin Fan, Laura Distel, Rui Xiao, Darko Stefanovski, Ignacio E. Tapia
Summary: This study examines the differences in sleep patterns among children with Obstructive Sleep Apnea Syndrome (OSAS) based on race, ethnicity, and socioeconomic status (SES). It also investigates the links between sleep patterns and neurobehavioral functioning. The results show that compared to White children, Black children with OSAS have shorter and more variable nighttime sleep duration. Lower family income is associated with sleep duration variability. Short and variable sleep duration are both related to caregiver-rated child inattention and impulsivity, while greater sleep duration variability is linked to greater teacher-rated executive functioning impairments.
Article
Nutrition & Dietetics
Yanhui Li, Di Gao, Li Chen, Tao Ma, Ying Ma, Manman Chen, Bin Dong, Yanhui Dong, Jun Ma, Luke Arnold
Summary: The study found a negative correlation between breastfeeding duration and lipid profile in children and adolescents, with this association increasing in magnitude with longer breastfeeding duration. Prolonged breastfeeding was associated with lower lipid levels and decreased risk of abnormal lipids, especially in children and young adolescents aged 5-14 years. This suggests that encouraging extended breastfeeding can improve childhood lipid profiles.
Article
Clinical Neurology
Yooha Hong, Heejung Mo, Soo-Jin Cho, Hee-Jin Im
Summary: This study found that short sleep duration and lack of compensation were significantly associated with wake-up stroke (WUS) in patients with low-risk obstructive sleep apnea (OSA). However, this association was not observed in the high-risk OSA group.
Article
Cardiac & Cardiovascular Systems
Rei Matsuo, Shigemasa Tani, Naoya Matsumoto, Yasuo Okumura
Summary: Inadequate sleep duration may affect lipid and/or glucose metabolism, with sex differences in the relationship between sleep duration and lipid/glucose metabolism in urban Japan highlighted. Emphasizing adequate sleep duration in both sexes may help reduce the risk of ASCVD.
Article
Public, Environmental & Occupational Health
Naoko Sakamoto, Kayoko Kabaya, Meiho Nakayama
Summary: This study examined the relationship between excessive use of digital devices, Internet addictive behavior, sleep duration, and sleep problems. The findings revealed that after adjusting for sleep duration, there was a relationship between three Internet addictive behaviors and sleep problems. Shorter weekday sleep duration and longer weekend sleep duration were also associated with higher likelihood of sleep problems.
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Article
Environmental Sciences
Chie Omichi, Hiroshi Kadotani, Yukiyoshi Sumi, Ayaka Ubara, Kohei Nishikawa, Arichika Matsuda, Yuji Ozeki
Summary: This study used home EEG measurements and questionnaire survey to identify the association between depressive symptoms and sleep latency and REM latency. The results suggest that depressive symptoms are associated with prolonged sleep latency and reduced REM latency in a Japanese working population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Clinical Neurology
Yukiyoshi Sumi, Hiroshi Kadotani, Yuji Ozeki
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Computer Science, Artificial Intelligence
Tsuyoshi Uchida, Koichi Fujiwara, Kenichi Nishioji, Masao Kobayashi, Manabu Kano, Yuya Seko, Kanji Yamaguchi, Yoshito Itoh, Hiroshi Kadotani
Summary: This study proposes a new method for analyzing the causal relationship in medical checkup data to discover factors of disease progression. By identifying the causal effects of checkup items on disease progression, the underlying mechanisms of diseases can be revealed. The proposed analysis framework can be applied to various medical checkup data and contribute to the discovery of unknown disease factors.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Article
Psychology, Clinical
Kaori Saitoh, Takuya Yoshiike, Yoshiyuki Kaneko, Tomohiro Utsumi, Kentaro Matsui, Kentaro Nagao, Rei Otsuki, Sayaka Aritake-Okada, Hiroshi Kadotani, Kenichi Kuriyama, Masahiro Suzuki
Summary: According to this longitudinal study, nonrestorative sleep (NRS) is a risk factor for incident depressive symptoms (DEPs) and can predict other insomnia-related symptoms.
DEPRESSION AND ANXIETY
(2022)
Article
Environmental Sciences
Kazuki Ito, Masahiro Uetsu, Ayaka Ubara, Arichika Matsuda, Yukiyoshi Sumi, Hiroshi Kadotani
Summary: This study compared newly diagnosed OSA patients in two outpatient sleep apnoea units, one associated with the psychiatry department and the other with the otolaryngology department. The unit associated with the psychiatry department had more patients referred by psychiatrists, while the unit associated with the otolaryngology department was more likely to diagnose snoring and moderate to severe OSA. The study found a negative association between OSA severity and depressive symptoms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Ayako Iwasaki, Koichi Fujiwara, Chikao Nakayama, Yukiyoshi Sumi, Manabu Kano, Tetsuharu Nagamoto, Hiroshi Kadotani
Summary: This study validates a SAS screening methodology using R-R interval and long short-term memory technology, achieving high screening performance in a large clinical dataset. The method can contribute to the realization of an easy-to-use SAS screening system.
CLINICAL NEUROPHYSIOLOGY
(2022)
Letter
Behavioral Sciences
Naoki Kuimoto, Toyohiko O'higashi, Hiroshi Kadotani, Seiji Ukai, Maki Yamada, Masahito Kitano, Takanori Kawamoto, Hiroki Enomoto, Kai Hashimoto, Fujiki Kurimoto
Article
Clinical Neurology
Noriko Nishikawa, Miho Murata, Taku Hatano, Yohei Mukai, Yuji Saitoh, Takashi Sakamoto, Takashi Hanakawa, Yuichi Kamei, Hisateru Tachimori, Kenji Hatano, Hiroshi Matsuda, Yosuke Taruno, Nobukatsu Sawamoto, Yuta Kajiyama, Kensuke Ikenaka, Kazuya Kawabata, Tomohiko Nakamura, Hirotaka Iwaki, Hiroshi Kadotani, Yukiyoshi Sumi, Yuichi Inoue, Toshihiro Hayashi, Takeshi Ikeuchi, Yasushi Shimo, Hideki Mochizuki, Hirohisa Watanabe, Nobutaka Hattori, Yuji Takahashi, Ryosuke Takahashi
Summary: iRBD is a specific prodromal symptom of synucleinopathies, including PD. The J-PPMI study aimed to investigate biomarkers in Japanese iRBD patients. DaT and MIBG were found to be important biomarkers for confirming synucleinopathies, with a majority of patients meeting PD diagnostic criteria.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Aoi Kawamura, Takuya Yoshiike, Masahiro Matsuo, Hiroshi Kadotani, Yuki Oike, Midori Kawasaki, Yuichi Kurumai, Kentaro Nagao, Masanori Takami, Naoto Yamada, Kenichi Kuriyama
Summary: This study investigated the feasibility of an automated sleep stage scoring system called Sleep Scope and compared it with the traditional polysomnography scoring method. The results showed that despite some biases, there was sufficient concordance between Sleep Scope and polysomnography, indicating that this automated staging system could serve as a novel clinical tool for reducing the time and expenses required of medical staff and patients.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
Chie Omichi, Teruhide Koyama, Hiroshi Kadotani, Etsuko Ozaki, Satomi Tomida, Tamami Yoshida, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Keitaro Tanaka, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Isao Oze, Keitaro Matsuo, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Kenichi Shibuya, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kenji Takeuchi, Kenji Wakai
Summary: This study investigates the association between subjective sleep duration and sleep regularity with mortality. The results show that irregular sleep is associated with an increased risk of all-cause mortality, regardless of sleep duration.
Article
Public, Environmental & Occupational Health
Chie Omichi, Yuki Kaminishi, Hiroshi Kadotani, Yukiyoshi Sumi, Ayaka Ubara, Kohei Nishikawa, Arichika Matsuda, Yuji Ozeki
Summary: This study investigated the relationship between social support, job stress, and mental health outcomes (depression, anxiety, insomnia) among Japanese workers. The findings suggest that job stress is associated with increased depressive symptoms, anxiety symptoms, and insomnia, while support from co-workers and family members may be linked to reduced depressive symptoms and insomnia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Public, Environmental & Occupational Health
Hiroshi Kadotani, Isa Okajima, Keming Yang, Michelle H. Lim
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Clinical Neurology
Akiko Hida, Aritoshi Iida, Motoki Ukai, Hiroshi Kadotani, Makoto Uchiyama, Takashi Ebisawa, Yuichi Inoue, Shingo Kitamura, Kazuo Mishima
Article
Clinical Neurology
Isa Okajima, Hiroshi Kadotani, NinJa Sleep Study Grp
Summary: It has been observed that reduced sleep reactivity and anxiety sensitivity are associated with decreased severity of insomnia. This study aimed to investigate the association of sleep reactivity and anxiety sensitivity with insomnia-related depression and anxiety in city government employees in Japan. The findings suggest a strong association between sleep reactivity and depressive symptoms, as well as between anxiety sensitivity and anxiety symptoms among individuals with insomnia.
Meeting Abstract
Clinical Neurology
C. Omichi, H. Kadotani, Y. Sumi, A. Ubara, K. Nishikawa, A. Matsuda, Y. Ozeki
JOURNAL OF SLEEP RESEARCH
(2022)
