Article
Clinical Neurology
Baixin Chen, Virend K. Somers, Qimeng Sun, Yanyuan Dai, Yun Li
Summary: The study found that objective excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA) is associated with increased sympathetic nerve activity (SNA) and higher diastolic blood pressure (BP), indicating a more severe phenotype of OSA that may lead to greater cardiovascular morbidity and mortality.
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Respiratory System
Francois Bettega, Clemence Leyrat, Renaud Tamisier, Monique Mendelson, Yves Grillet, Marc Sapene, Maria R. Bonsignore, Jean Louis Pepin, Michael W. Kattan, Sebastien Bailly
Summary: This study demonstrates how two causal inference methods can be used to assess the impact of CPAP adherence on daytime sleepiness in patients with OSA. The results indicate a causal effect of CPAP adherence on daytime sleepiness, with differences observed between lower and higher adherence groups, while no significant differences were found when considering higher levels of adherence.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Neurosciences
Naima Covassin, Dongmei Lu, Erik K. K. St Louis, Anwar A. A. Chahal, Phillip J. J. Schulte, Meghna P. P. Mansukhani, Jiang Xie, Melissa C. C. Lipford, Nanfang Li, Kannan Ramar, Sean M. M. Caples, Peter C. C. Gay, Eric J. J. Olson, Michael H. H. Silber, Jingen Li, Virend K. K. Somers
Summary: The study aimed to assess the associations between excessive daytime sleepiness (EDS) and chronic diseases and mortality in men and women with obstructive sleep apnea (OSA). The results showed that EDS was associated with a lower risk of hypertension in male OSA patients and a higher risk of diabetes mellitus in both OSA men and women. In women, EDS was also independently associated with a higher risk of premature death.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Park Geun Hyung, Koh Tae Kyung, Koo Soo Kweon, Yoon Byung Woo, Lee Sang Hoon, Ji Chang Lok, Woo Joo Young
Summary: This study investigated the prevalence of REM-OSA in a Korean population sample and found that despite its relatively low prevalence, REM-OSA may reduce sleep quality and increase daytime sleepiness.
SLEEP AND BREATHING
(2023)
Review
Pharmacology & Pharmacy
Jiahe Wang, Xiang Li, Siyuan Yang, Tianyi Wang, Zhongmou Xu, Jianguo Xu, Heng Gao, Gang Chen
Summary: Pitolisant demonstrated efficacy and controllable safety in treating excessive daytime sleepiness in patients with narcolepsy and OSA, showing reductions in ESS score, increased sleep latency, and improved quality of life. However, treatment with pitolisant may lead to insomnia as a treatment-emergent adverse event, emphasizing the importance of monitoring and management.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Charley Ximing Jin, Kate Sutherland, Thorarinn Gislason, Elin Helga Thorarinsdottir, Lia Bittencourt, Sergio Tufik, Bhajan Singh, Nigel McArdle, Peter Cistulli, Yu Sun Bin
Summary: Social jetlag is associated with daytime sleepiness in patients with obstructive sleep apnea (OSA). The study found that social jetlag of over 2 hours was significantly associated with higher levels of daytime sleepiness. Improving sleep timing could be a simple therapeutic target for reducing the impact of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Zili Meng, Bing Sun, Wei Chen, Xilong Zhang, Mao Huang, Jing Xu
Summary: The co-occurrence of excessive daytime sleepiness (EDS) and hypertension is common in obstructive sleep apnea syndrome (OSAS), with more severe OSAS severity indices observed in patients with both conditions. Increased cardiac sympathovagal imbalance and nocturnal hypoxemia regulate the presence of EDS and hypertension. Plasma biomarker analysis revealed a significant association between decreased ACh levels and the presence of EDS and hypertension in OSAS patients.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Riikka Huhta, Kari Hirvonen, Markku Partinen
Summary: The study found that moderate sleep apnea is common among professional truck drivers, but significant inability to stay awake is found in about one of twenty drivers. The prevalence varied depending on different criteria, with some participants showing abnormally short sleep latency in the maintenance of wakefulness test.
Review
Psychiatry
Danwei Zhang, Zhen Zhang, Huihua Li, Kaimo Ding
Summary: The study indicates a significant relationship between excessive daytime sleepiness (EDS), depression, and obstructive sleep apnea (OSA). Continuous Positive Airway Pressure (CPAP) has been proven to be an effective therapy for improving EDS and depression in patients with OSA.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Otorhinolaryngology
Sang Hoo Park, Woo Yong Bae, Sangjun Kim, Young Gun Kim, Young Bin Yun, Hyung Geun Lee, Bok Joo Kim, Jung-han Kim
Summary: This study aimed to compare the improvement and non-improvement groups of excessive daytime sleepiness in patients with obstructive sleep apnea (OSA). The results showed significant differences between the groups in Social Avoidance and Distress Scale (SADS), Fear of Negative Evaluation (FNE), apnea index (AI), apnea-hypopnea index (AHI), percentage of stage 2 non-REM sleep (N2%), and frequency of 3% oxygen desaturation (ODI3).
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
Helena Martynowicz, Rafal Poreba, Tomasz Wieczorek, Zygmunt Domagala, Robert Skomro, Anna Wojakowska, Sylwia Winiewska, Piotr Macek, Grzegorz Mazur, Pawel Gac
Summary: The aim of this study was to examine the sleep patterns and daytime sleepiness in patients with erectile dysfunction. The researchers studied 280 patients, with 107 of them reporting erectile dysfunction, and 173 without a history of erectile dysfunction serving as the control group. The results showed that patients with erectile dysfunction had altered sleep architecture, lower oxygen saturation levels, and increased daytime sleepiness compared to the control group.
Article
Critical Care Medicine
Younghoon Kwon, Scott A. Sands, Katie L. Stone, Luigi Taranto-Montemurro, Raichel M. Alex, David P. White, Andrew Wellman, Susan Redline, Ali Azarbarzin
Summary: Sleep study-derived circulation time (LFCt) is associated with cardiovascular and all-cause mortality in older men, independent of baseline cardiovascular burden and sleep-disordered breathing metrics, suggesting it may serve as a novel physiological marker for subclinical cardiovascular disease and adverse outcomes.
Article
Medicine, General & Internal
Elisabet Svenungsson, Jonas Spaak, Karin Strandberg, Hakan N. Wallen, Stefan Agewall, Elin B. Brolin, Olov Collste, Maria Daniel, Christina Ekenback, Mats Frick, Loghman Henareh, Karin Malmqvist, Kerstin Elvin, Peder Sorensson, Shams Y-Hassan, Claes Hofman-Bang, Per Tornvall
Summary: Recent studies have shown an overrepresentation of prothrombotic antiphospholipid antibodies in patients with myocardial infarction due to coronary artery disease, but their association with MI with nonobstructive coronary arteries remains unclear. This study confirmed the higher levels of aPL IgG in patients with MI due to coronary artery disease, indicating a potential link with hypercoagulability.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Kristina Lundwall, Andreas Jekell, Liyew Desta, Stefan H. Jacobson, Thomas Kahan, Jonas Spaak
Summary: The combination of hypertension and chronic kidney disease can lead to cardiovascular disease and loss of renal function. This study found that increased arterial stiffness and aortic-brachial stiffness mismatch are independently related to reduced renal function in hypertensive patients. These markers may be useful in identifying hypertensive patients at risk for decline in renal function.
Article
Cardiac & Cardiovascular Systems
Joel Lenell, Bertil Lindahl, Per Karlsson, Gorav Batra, David Erlinge, Tomas Jernberg, Jonas Spaak, Tomasz Baron
Summary: The study aimed to validate the reported LVEF values in the SWEDEHEART registry for ACS patients in Sweden, and found good agreement with independently re-evaluated LVEF. However, a tendency towards underestimation of LVEF was observed, suggesting cautious interpretation of the reported LVEF assessment.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Norm R. C. Campbell, Paul K. Whelton, Marcelo Orias, Richard D. Wainford, Francesco P. Cappuccio, Nicole Ide, Bruce Neal, Jennifer Cohn, Laura K. Cobb, Jacqui Webster, Kathy Trieu, Feng J. He, Rachael M. McLean, Adriana Blanco-Metzler, Mark Woodward, Nadia Khan, Yoshihiro Kokubo, Leo Nederveen, JoAnne Arcand, Graham A. MacGregor, Mayowa O. Owolabi, Liu Lisheng, Gianfranco Parati, Daniel T. Lackland, Fadi J. Charchar, Bryan Williams, Maciej Tomaszewski, Cesar A. Romero, Beatriz Champagne, Mary R. L'Abbe, Michael A. Weber, Markus P. Schlaich, Agnes Fogo, Valery L. Feigin, Rufus Akinyemi, Felipe Inserra, Bindu Menon, Marcia Simas, Mario Fritsch Neves, Krassimira Hristova, Carolyn Pullen, Sanjay Pandeya, Junbo Ge, Jorge E. Jalil, Ji-Guang Wang, Jiri Wideimsky, Reinhold Kreutz, Ulrich Wenzel, Michael Stowasser, Manuel Arango, Athanasios Protogerou, Eugenia Gkaliagkousi, Flavio Danni Fuchs, Mansi Patil, Andy Wai-Kwong Chan, Janos Nemcsik, Ross T. Tsuyuki, Sanjeevi Nathamuni Narasingan, Nizal Sarrafzadegan, Maria Eugenia Ramos, Natalie Yeo, Hiromi Rakugi, Agustin J. Ramirez, Guillermo Alvarez, Adel Berbari, Cho-il Kim, Sang-Hyun Ihm, Yook-Chin Chia, Tsolmon Unurjargal, Hye Kyung Park, Kolawole Wahab, Helen McGuire, Naranjargal J. Dashdorj, Mohammed Ishaq, Deborah Ignacia D. Ona, Leilani B. Mercado-Asis, Aleksander Prejbisz, Marianne Leenaerts, Carla Simao, Fernando Pinto, Bader Ali Almustafa, Jonas Spaak, Stefan Farsky, Dragan Lovic, Xin-Hua Zhang
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Jean-Claude Wautrecht, Dan-Mircea Olinic, Mariella Catalano, Colin Baines, Jill Belch, Ales Blinc, Ivo Buschmann, Denisa Celovska, Mary-Paula Colgan, Evangelos Dimakakos, Christian Heiss, Endre Kolossvary, Matija Kozak, Bram Kroon, Lucia Mazzolai, George Marakomichelakis, Zsolt Pecsvarady, Maria A. Pias Canedo, Isabelle Quere, Karel Roztocil, Gerit H. Schernthaner, Aleksander Sieron, Jonas Spaak, Muriel Sprynger, Agata Stanek, Daniel Staub, Dragan Vasic, Adriana Visona, andrea Willfort-Ehringer
INTERNATIONAL ANGIOLOGY
(2022)
Article
Medicine, Research & Experimental
Erik M. G. Olsson, Fredrika Norlund, Elisabet Rondung, Sophia M. Humphries, Claes Held, Patrik Lynga, Jonas Spaak, Orjan Sundin, Runa Sundelin, Philip Leissner, Lena Kovamees, Per Tornvall
Summary: This study aims to evaluate the effectiveness of Internet-based cognitive behavior therapy (CBT) in reducing stress and anxiety in patients with MINOCA or TS. A randomized controlled trial will be conducted on 90 patients, with half receiving 10 weeks of Internet-based CBT and the other half receiving usual care. The main outcomes will be anxiety symptoms and stress levels measured using standardized scales. Long-term follow-up will compare the effects of early intervention and late intervention.
Article
Health Care Sciences & Services
Kay Sundberg, Athena Adeli, Helge Brandberg, Jonas Spaak, Sabine Koch, Carl J. Sundberg, David Zakim, Thomas Kahan, Kaisa Fritzell
Summary: Most patients had a positive experience with the CLEOS program in the ED setting, although some found it to be extensive. Adjustments to the extent of the interview for better adaptation to the clinical setting should be the future development of the program.
HEALTH EXPECTATIONS
(2022)
Article
Psychology, Clinical
Elisabet Rondung, Sophia Monica Humphries, Erik Martin Gustaf Olsson, Runa Sundelin, Fredrika Norlund, Claes Held, Jonas Spaak, Per Tornvall, Patrik Lynga
Summary: This study aimed to evaluate the effects of an internet-based intervention on patients with stress and anxiety after myocardial infarction. Through a small-scale single arm study, the feasibility of conducting a large-scale randomized controlled trial (RCT) was demonstrated, with improvements made to the study protocol and intervention.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Emma Berg, Stefan Agewall, Elin Bacsovics Brolin, Kenneth Caidahl, Kerstin Cederlund, Olov Collste, Maria Daniel, Christina Ekenback, Jens Jensen, Shams Y-Hassan, Loghman Henareh, Eva Maret, Jonas Spaak, Peder Sorensson, Per Tornvall, Patrik Lynga
Summary: Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) did not show improvement in Health-related quality-of-life (HRQoL) during the first year after the acute event, indicating a need for increased follow-up and psychological support.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Josefin Mortberg, Barbara Salzinger, Kristina Lundwall, Robert Edfors, Stefan H. Jacobson, Hakan N. Wallen, Tomas Jernberg, Tomasz Baron, David Erlinge, Pontus Andell, Stefan James, Kai M. Eggers, Marcus Hjort, Thomas Kahan, Pia Lundman, Per Tornvall, Melinda Rezeli, Gyorgy Marko-Varga, Bertil Lindahl, Jonas Spaak
Summary: This study evaluated the prognostic importance of selected biomarkers related to haemostasis, endothelial function, and vascular regulation in patients with ACS and assessed whether this association differed in patients with renal dysfunction. The results showed that adrenomedullin, suPAR, and renin were independently associated with the composite outcome, and adrenomedullin showed a significant interaction with renal function and outcome, being associated with the composite outcome only in patients with preserved kidney function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Masih Khedri, Karolina Szummer, Pia Lundman, Tomas Jernberg, Liyew Desta, Bertil Lindahl, David Erlinge, Stefan H. Jacobson, Jonas Spaak
Summary: Statin dosage in patients with acute myocardial infarction (AMI) and concomitant kidney dysfunction is a clinical dilemma. We studied discontinuation during the first year after an AMI and long-term outcome in patients receiving high versus low-moderate intensity statin treatment, in relation to kidney function. Our results showed that high-intensity statin treatment is associated with improved long-term outcome after AMI in patients with reduced kidney function.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Christina Montgomerie, Jonas Spaak, Marie Evans, Stefan H. Jacobson
Summary: This study provides a detailed description of community-acquired acute kidney injury (AKI) and comprehensive analyses of integrated clinical and laboratory data associated with kidney recovery. Features related to anemia, albuminuria, malnutrition, inflammation, and acidosis are associated with partial or moderate short-term recovery of kidney function, disturbances in potassium homeostasis, and in-hospital mortality.
Article
Biochemistry & Molecular Biology
Jonatan Warme, Martin O. Sundqvist, Marcus Hjort, Stefan Agewall, Olov Collste, Christina Ekenback, Mats Frick, Loghman Henareh, Claes Hofman-Bang, Jonas Spaak, Peder Sorensson, Shams Y-Hassan, Per Svensson, Bertil Lindahl, Robin Hofmann, Per Tornvall
Summary: Helicobacter pylori (Hp) infection is associated with protein biomarkers of inflammation and cardiovascular disease (CVD) in patients with myocardial infarction (MI) irrespective of the presence of obstructive coronary artery disease (CAD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Informatics
Moman A. Mohammad, Kevin K. W. Olesen, Sasha Koul, Chris P. Gale, Rebecca Rylance, Tomas Jernberg, Tomasz Baron, Jonas Spaak, Stefan James, Bertil Lindahl, Michael Maeng, David Erlinge
Summary: Patients who survive myocardial infarction have a high risk of mortality and developing heart failure. This study aimed to evaluate the accuracy of an artificial neural network algorithm in predicting 1-year mortality and hospital admission for heart failure after myocardial infarction. The algorithm showed good predictive ability and could potentially help identify high-risk patients for tailored therapies and monitoring.
LANCET DIGITAL HEALTH
(2022)