Article
Medicine, Research & Experimental
Kun Wu, Chong Guo, Yixun Li, Jinrong Yang, Qiang Zhou, Shenju Cheng, Yanhong Li, Bo Nie, Yun Zeng
Summary: The Warburg effect, involved in drug resistance and recurrence of cancer, presents a challenge for CML treatment. MiR-18a-5p targeting HIF-1 alpha may suppress the Warburg effect by inhibiting aerobic glycolysis, suggesting a potential therapeutic strategy for CML.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Environmental Sciences
Qingpeng Zhang, Wenting Xia, Xingyue Zhou, Chengying Yang, Ziwei Lu, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: This study observed the effects of PS-MPs, CdCl2, and their mixture on the reproductive function of male mice. The results showed that chronic exposure to PS-MPs damaged testicular tissue, reduced sperm quality, and testosterone levels. Co-exposure to PS-MPs and Cd exacerbated reproductive injury. Furthermore, the study found that the testicular damage was associated with interference in the miR-199a-5p/HIF-1α/ferroptosis pathway.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Dongxian Peng, Tingting Wu, Junxia Wang, Jie Huang, Lijiao Zheng, Pingping Wang, Junpeng Li, Lin Wu, Min Luo
Summary: miR-671-5p reduces the tumorigenicity of OC by suppressing the expression levels of HDAC5 and HIF-1 alpha.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Chunyan Guo, Minghui Zhang, Wei Su, Min Xu, Shumei Zhao
Summary: This study found that miR-199a-5p may relieve OSAS-related hypertension by targeting HIF-1 alpha and could serve as a potential therapeutic target.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Daolu Zhan, Mingxia Lin, Jian Chen, Wentao Cai, Jian Liu, Yehan Fang, Yibo Li, Bin Wu, Guangji Wang
Summary: The study identified 994 significant differentially expressed miRNAs in NPCs, with miR-32-5p being upregulated. PTEN was downregulated in NPCs from non-degenerative disc tissues of young patients. Through regulation of the HIF-1 alpha/miR-32-5p/PTEN/PI3K/AKT/mTOR axis, cell proliferation and apoptosis were controlled in NPCs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Article
Ophthalmology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: The study aimed to determine the necessity of HIF-1a on PR cell survival after RD. The findings suggest that rod-derived HIF-1a plays a key role in promoting PR cell survival.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Plant Sciences
Wang Feng, Zhao Ying, Fan Ke, Xie Mei-Lin
Summary: The study found that apigenin could suppress the differentiation and collagen synthesis of TGF-beta 1-stimulated CFs and mouse cardiac fibrosis by increasing miR-122-5p expression and downregulating HIF-1 alpha expression.
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Article
Physiology
He Huang, Shenwei Xie, Xiaolan Gu, Bin Xiang, Zhifeng Zhong, Pei Huang, Yuqi Gao, Peng Li
Summary: The study found that the level of circulating miR-199a-5p is positively associated with exercise capacity during chronic hypoxia at high altitudes, and higher miR-199a-5p is involved in hypoxia-induced cardiovascular dysfunctions, contributing to poorer exercise endurance at high altitudes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Article
Medicine, Research & Experimental
Ni Zeng, Yu-Qing Huang, Yu-Min Yan, Zhi-Qin Hu, Zhuo Zhang, Jia-Xin Feng, Ji-Shen Guo, Jie-Ning Zhu, Yong-Heng Fu, Xi-Pei Wang, Meng-Zhen Zhang, Jin-Zhu Duan, Xi-Long Zheng, Jin-Dong Xu, Zhi-Xin Shan
Summary: miR-199a-5p and -3p are co-upregulated in the myocardium during cardiac remodeling and can aggravate cardiac hypertrophy and fibrosis by targeting different genes. Inhibition of miR-199a-5p and -3p may present a new therapeutic strategy for cardiac remodeling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Immunology
Gabriela Burczyk, Iwona Cichon, Elzbieta Kolaczkowska
Summary: 4-octyl itaconate (4-OI) diminishes the formation of neutrophil extracellular traps (NETs) in mice, regardless of their health status or metabolic challenges. The inhibition is mediated by downregulating Hif-1 alpha and inducing HO-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Zhihai Huang, Weiliang Guan, Xiaobo Wei, Renchi Chen, Xiamin Lyu, Gaohai Zheng, Linchun Mao
Summary: The study found that HIF-1 alpha can protect whiteleg shrimp hemocytes from apoptosis caused by air exposure through upregulating the expression of HSP70 and decreasing intracellular ROS production.
Article
Cardiac & Cardiovascular Systems
Emilia M. Swietlik, Daniel Greene, Na Zhu, Karyn Megy, Marcella Cogliano, Smitha Rajaram, Divya Pandya, Tobias Tilly, Katie A. Lutz, Carrie C. L. Welch, Michael W. Pauciulo, Laura Southgate, Jennifer M. Martin, Carmen M. Treacy, Christopher J. Penkett, Jonathan C. Stephens, Harm J. Bogaard, Colin Church, Gerry Coghlan, Anna W. Coleman, Robin Condliffe, Christina A. Eichstaedt, Melanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Ekkehard Grunig, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. Mackenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Jay Suntharalingam, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, James M. Wild, Stephen John Wort, Allan Lawrie, Martin R. Wilkins, Richard C. Trembath, Yufeng Shen, Wendy K. Chung, Andrew J. Swift, William C. Nichols, Nicholas W. Morrell, Stefan Graf
Summary: Approximately 25% of PAH patients have rare mutations in disease-causing genes. By integrating deep phenotyping with whole-genome sequencing, we identified a novel candidate gene, KDR, associated with distinct phenotypes in PAH. This finding highlights the importance of the vascular endothelium in the pathobiology of PAH.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Peripheral Vascular Disease
Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie Jose Goumans, Rolf M. F. Berger
Summary: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by obstructive pulmonary vascular remodeling. Targeting Pin1 could potentially reverse the phenotype of PAH through modulation of TGF-beta/BMP signaling pathways, providing a novel therapeutic option for PAH treatment.
Article
Respiratory System
Natalia J. Braams, Gudula J. A. M. Boon, Frances S. de Man, Josien van Es, Paul L. den Exter, Lucia J. M. Kroft, Ludo F. M. Beenen, Menno Huisman, Esther J. Nossent, Anco Boonstra, Anton Vonk Noordegraaf, Dieuwertje Ruigrok, Frederikus A. Klok, Harm Jan Bogaard, Lilian J. Meijboom
Summary: In patients with acute PE, central thrombi resolved after anticoagulant treatment, while mural thrombi and total thrombotic occlusions either resolved or evolved into webs or tapered pulmonary arteries. Patients with a diagnosis of CTEPH had webs and tapered pulmonary arteries on the baseline scan, which persisted after follow-up. Webs and tapered pulmonary arteries at the time of PE diagnosis strongly indicate a state of chronic PE and should raise awareness for possible CTEPH.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Critical Care Medicine
Xue D. Manz, Robert Szulcek, Xiaoke Pan, Petr Symersky, Chris Dickhoff, Jisca Majolee, Veerle Kremer, Elisabetta Michielon, Ekaterina S. Jordanova, Teodora Radonic, Irene Bijnsdorp, Sander R. Piersma, Thang Pham, Connie R. Jimenez, Anton Vonk Noordegraaf, Frances S. de Man, Reinier A. Boon, Jan Voorberg, Peter L. Hordijk, Jurjan Aman, Harm Jan Bogaard
Summary: This study identifies the role of von Willebrand factor (vWF) in chronic thromboembolic pulmonary hypertension (CTEPH). Increased vWF levels in plasma and pulmonary endothelium of CTEPH patients contribute to elevated platelet adhesion to CTEPH endothelium. The increased expression of nuclear factor (NF)-kappa B2 and epigenetic modifications of the vWF promoter play a critical role in driving vWF transcription and promoting a prothrombotic phenotype in CTEPH-pulmonary artery endothelial cells.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jessie van Wezenbeek, Azar Kianzad, Arno van de Bovenkamp, Jeroen Wessels, Sophia A. Mouratoglou, Natalia J. Braams, Samara M. A. Jansen, Eva Meulblok, Lilian J. Meijboom, J. Tim Marcus, Anton Vonk Noordegraaf, Marie Jose Goumans, Harm Jan Bogaard, M. Louis Handoko, Frances S. de Man
Summary: This study compared cardiac function in HFpEF, HFpEF-PH, and PAH patients and found that despite similar pressure overload, RV/RA function was less compromised in HFpEF-PH compared to PAH. The increased RA pressure and stiffness in HFpEF-PH were explained by left atrial/RA interaction.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Jessie van Wezenbeek, Joanne A. Groeneveldt, Aida Llucia-Valldeperas, Cathelijne E. van Der Bruggen, Samara M. A. Jansen, A. Josien Smits, Rowan Smal, Joost W. van Leeuwen, Cris dos Remedios, Anne Keogh, Marc Humbert, Peter Dorfmuller, Olaf Mercier, Christophe Guignabert, Hans W. M. Niessen, M. Louis Handoko, J. Tim Marcus, Lilian J. Meijboom, Frank P. T. Oosterveer, Berend E. Westerhof, Annemieke C. Heijboer, Harm Jan Bogaard, Anton Vonk Noordegraaf, Marie Jose Goumans, Frances S. de Man
Summary: This study investigated the association between altered sex hormone expression and long-term right ventricular adaptation and progression of right heart failure in patients with pulmonary arterial hypertension across a wide range of ages.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Leila Atmowihardjo, Job R. Schippers, Imke H. Bartelink, Pierre M. Bet, Nienke van Rein, Keith Purdy, David Cavalla, Valerie Comberiati, Andrew McElroy, Sue D. Snape, Harm Jan Bogaard, Leo Heunks, Nicole Juffermans, Marcus Schultz, Pieter R. Tuinman, Lieuwe D. J. Bos, Jurjan Aman
Summary: This study aims to investigate the efficacy and safety of IV imatinib in mechanically ventilated subjects with COVID-19-related ARDS. By reducing pulmonary edema, it may contribute to improving respiratory function and speeding up recovery.
Article
Multidisciplinary Sciences
V. F. E. D. Smolders, C. Rodriguez, I Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Moren, C. Bonjoch, L. Sebastian, M. Castella, J. Osorio, V. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J. A. Barbera, O. Tura-Ceide
Summary: This study compares the metabolic characteristics of endothelial cells from patients with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH), and finds differences between them, suggesting different disease pathology and treatment mechanisms.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Arno A. van de Bovenkamp, Niels Wijkstra, Frank P. T. Oosterveer, Anton Vonk Noordegraaf, Harm Jan Bogaard, Albert C. van Rossum, Frances S. de Man, Barry A. Borlaug, M. Louis Handoko
Summary: PCWPPLR during a passive leg raise can be a simple and powerful tool to diagnose or rule out occult-HFpEF, especially for patients with normal left ventricular filling pressures at rest.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Azar Kianzad, Jessie van Wezenbeek, Lucas R. Celant, Frank P. T. Oosterveer, Anton Vonk Noordegraaf, Lilian J. Meijboom, Frances S. de Man, Harm Jan Bogaard, M. Louis Handoko
Summary: The aim of this study was to determine whether the H2FPEF score identifies a subgroup of iPAH patients with a blunted response to PAH-targeted treatment. The results showed that patients with a high H2FPEF score had differences in age, gender, obesity, and comorbidities, and were associated with worse survival and functional capacity. However, the H2FPEF score did not predict the hemodynamic and functional responses to PAH treatment.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Critical Care Medicine
Matina Prapa, Mauro Lago-Docampo, Emilia M. Swietlik, David Montani, Melanie Eyries, Marc Humbert, Carrie L. Welch, Wendy K. Chung, Rolf M. F. Berger, Harm Jan Bogaard, Olivier Danhaive, Pilar Escribano-Subias, Henning Gall, Barbara Girerd, Ignacio Hernandez-Gonzalez, Simon Holden, David Hunt, Samara M. A. Jansen, Wilhelmina Kerstjens-Frederikse, David G. Kiely, Pablo Lapunzina, John McDermott, Shahin Moledina, Joanna Pepke-Zaba, Gary J. Polwarth, Gwen Schotte, Jair Tenorio-Castano, A. A. Roger Thompson, John Wharton, Stephen J. Wort, Karyn Megy, Rutendo Mapeta, Carmen M. Treacy, Jennifer M. Martin, Wei Li, Andrew J. Swift, Paul D. Upton, Nicholas W. Morrell, Stefan Graf, Diana Valverde
Summary: This study analyzed TBX4-associated pulmonary arterial hypertension and found that TBX4 variants can cause both loss-of-function and gain-of-function effects. The differential impact of pathogenic mutations located in critical protein domains may explain the pleiotropic effects of TBX4 in lung disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Justin de Brabander, Erik Duijvelaar, Job R. Schippers, Patrick J. Smeele, Hessel Peters-Sengers, Jan Willem Duitman, Jurjan Aman, Harm Jan Bogaard, Tom van der Poll, Lieuwe D. J. Bos
Summary: The effect of imatinib on mortality in hospitalised COVID-19 patients is mediated through modulation of innate immune responses and reversal of endothelial dysfunction, and possibly moderated by biological subphenotypes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Hematology
Xue D. Manz, Harm Jan Bogaard, Jurjan Aman
Summary: Increasing evidence suggests that inflammation promotes thrombosis via VWF-mediated mechanisms, and aberrant regulation of VWF is linked to various cardiovascular diseases. Recent insights from clinical diseases provide evidence for direct molecular links between inflammation and thrombosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Oncology
Nicole E. Billingy, Vashti N. M. F. Tromp, Neil K. Aaronson, Rianne J. A. Hoek, Harm Jan Bogaard, Bregje D. Onwuteaka-Philipsen, Lonneke van de Poll-franse, Jacqueline G. Hugtenburg, Jose Belderbos, Annemarie Becker-Commissaris, Corina J. G. van den Hurk, Iris Walraven, N. C. van Walree, K. de Jaeger, S. Samii, W. Y. Lam-Wong, F. Koppe, J. A. Stigt, G. J. M. Herder, A. Welling, O. C. J. Schuurbiers-Siebers, J. M. Smit, A. J. van den Brekel, W. K. de Jong
Summary: This study compared the effect of reactive and active approaches in monitoring patient-reported outcome measures (PROMs) for lung cancer patients. The results showed that weekly PRO symptom monitoring significantly improved health-related quality of life (HRQOL) in these patients, with the reactive approach being more suitable for implementation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Health Care Sciences & Services
Nadia Baalbaki, Jelle M. Blankestijn, Mahmoud I. Abdel-Aziz, Jan de Backer, Somayeh Bazdar, Ines Beekers, Rosanne J. H. C. G. Beijers, Joop P. van den Bergh, Lizan D. Bloemsma, Harm Jan Bogaard, Job J. M. H. van Bragt, Vera van den Brink, Jean Paul Charbonnier, Merel E. B. Cornelissen, Yennece Dagelet, Elin Haf Davies, Anne M. van der Does, George S. Downward, Cornelis M. van Drunen, Debbie Gach, J. J. Miranda Geelhoed, Jorrit Glastra, Kornel Golebski, Irene H. Heijink, Judith C. S. Holtjer, Sebastiaan Holverda, Laura Houweling, John J. L. Jacobs, Renee Jonker, Renate Kos, Ramon C. J. Langen, Ivo van der Lee, Asabi Leliveld, Firdaus A. A. Mohamed Hoesein, Anne H. Neerincx, Lieke Noij, Johan Olsson, Marianne van de Pol, Simon D. Pouwels, Emiel Rolink, Michael Rutgers, Havva Sahin, Daphne Schaminee, Annemie M. W. J. Schols, Lisanne Schuurman, Gitte Slingers, Olie Smeenk, Brigitte Sondermeijer, Paul J. Skipp, Marisca Tamarit, Inge Verkouter, Roel Vermeulen, Rianne de Vries, Els J. M. Weersink, Marco van de Werken, Yolanda de Wit-van Wijck, Stewart Young, Esther J. Nossent, Anke H. van der Zee
Summary: The P4O2 COVID-19 study aims to identify long COVID patients at risk for developing chronic lung disease and to find personalized therapeutic strategies. The study showed persistent symptoms and abnormalities in post-COVID patients, with the most commonly reported symptoms being respiratory and neurological symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2023)