Review
Multidisciplinary Sciences
Fengling Hu, Chutong Lin, Hongling Chu, Peng Ren, Jingdi Wang, Shaohua Ma
Summary: This study conducted a systematic review and meta-analysis to evaluate the survival difference between N1h and N1p in patients with pN1M0 NSCLC. The results showed that patients with N1p metastasis had a better prognosis compared to those with N1h metastasis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yuki Shimizu, Terumoto Koike, Toshiki Hasebe, Masaya Nakamura, Tatsuya Goto, Shin-ichi Toyabe, Masanori Tsuchida
Summary: This study aimed to investigate the risk factors for poor postoperative survival and recurrence in patients with NSCLC and nodal metastasis who were surgically treated and did not receive any induction treatments. Multiple-node metastases are risk factors for both poor survival and recurrence. Additional perioperative therapies may be required, especially in patients with squamous cell carcinoma.
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Surgery
Klaas Van Den Heede, Nele Brusselaers, Esmee Breddels, Sebastien Gaujoux, Camille Buffet, Fabrice Menegaux, Nathalie Chereau
Summary: This study evaluated the prognostic impact of lymph node characteristics on patients with therapeutic neck dissection for clinically N1 classic PTC. The results showed that the number of harvested lymph node, presence of lymph node capsular rupture, and total lymph node ratio were associated with disease persistence or recurrence.
Article
Oncology
Jian-Xun Chen, Ting-Yu Lu, Yu-Sen Lin, Hsin-Yuan Fang, Pin-Keng Shih
Summary: This study evaluates the impact of PET/CT on tumor recurrence in pN0 NSCLC patients with tumor less than 4 cm, indicating that the presence of positive lymph nodes on PET/CT scans is associated with a higher risk of recurrence. Factors such as tumor SUVmax, positive lymph nodes on PET/CT, and tumor differentiation are significant in predicting tumor recurrence in this patient population.
Article
Medicine, General & Internal
Lu Han, Hui Jia, Pingping Song, Xibin Liu, Zhendan Wang, Dujian Zhang
Summary: This study found that lobar lymph node metastasis is common in patients with lung cancer, while lymph node metastasis in non-tumor-bearing segments is rare. Age, differentiation, and the status of lymph nodes found on CAT scan are independent risk factors for lobar lymph node involvement. Further investigation is needed to determine the necessity of lymph node dissection in non-tumor-bearing segments.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Brooks Udelsman, David C. Chang, Daniel J. Boffa, Henning A. Gaissert
Summary: This study investigated adherence to guidelines regarding lymph node sampling during lobectomy for non-small cell lung cancer (NSCLC), and its association with hospital lobectomy volume. The results showed that the average rate of >= 10 lymph nodes harvested per lobectomy was higher in medium- to high-volume hospitals. However, 25% of high-volume hospitals still had a lymph node yield of <10 nodes, which may lead to inaccurate staging and have implications for adjuvant therapy and long-term survival.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Sevinc Citak, Talha Dogruyol, Serkan Bayram, Mustafa Vayvada, Serda Kanbur Metin, Volkan Baysungur
Summary: This study aimed to evaluate the effect of lymph node dissection method on staging results, diagnosis of tumor metastasis, and survival rates in NSCLC patients. The results showed that it is easier to detect lymph node involvement without introducing formaldehyde, and it is recommended to perform lymph node dissection on fresh specimens.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Review
Endocrinology & Metabolism
Federica Grillo, Manuela Albertelli, Pasqualino Malandrino, Andrea Dotto, Genoveffa Pizza, Giuseppe Cittadini, Annamaria Colao, Antongiulio Faggiano
Summary: Well-differentiated, low-grade neuroendocrine tumors (NETs) in the small bowel have a tendency to metastasize despite their slow growth. Extended regional mesenteric lymphadenectomy and the presence of mesenteric tumor deposits (MTDs) may be prognostic indicators for small bowel NETs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Di Zhou, Dongsheng Yue, Zhenfa Zhang, Pengfei Tian, Yingnan Feng, Zuo Liu, Bin Zhang, Meng Wang, Xiaoliang Zhao, Changli Wang
Summary: This study investigated the prognostic significance of station 4R lymph node (LN) dissection in patients with right primary non-small cell lung cancer (NSCLC). The results showed that station 4R dissection improved disease-free survival (DFS) and overall survival (OS) rates in these patients. These findings suggest that station 4R dissection should be recommended as a routine procedure for right primary NSCLC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Kamigaichi, Keiju Aokage, Shinya Katsumata, Genichiro Ishii, Masashi Wakabayashi, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Masahiro Tsuboi
Summary: This study evaluated the prognostic impact of examining the number of individual mediastinal lymph nodes (mLNs) in patients with resectable non-small cell lung cancer (NSCLC). The results showed that examining >= 3 mLNs was associated with better prognosis and lower risk of lymph node recurrence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Bo-Guen Kim, Jong Ho Cho, Sun Hye Shin, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Jhingook Kim, Young Mog Shim, Byeong-Ho Jeong
Summary: Endosonography is recommended for nodal staging in NSCLC patients with radiological N1. However, the diagnostic sensitivity of endosonography for detecting OMM was only 40%, indicating the need for caution in interpreting the results.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Yeqing Zhu, Qiang Cai, Yong Wang, Nan You, Rowena Yip, Dong-Seok Lee, Emanuela Taioli, Raja Flores, Claudia I. Henschke, David F. Yankelevitz
Summary: In this study, it was found that CT and SUVmax had low sensitivity but high specificity for predicting MLN metastases in solid NSCLCs with diameters between 10.1-30.0 mm. The optimal cutoff values for prediction were determined to be >18.9 mm for CT maximum short-axis diameter and >=11.7 for highest SUVmax.
Article
Medicine, Research & Experimental
Guanqun Yang, Siqi Cai, Mengyu Hu, Chaozhuo Li, Liying Yang, Wei Zhang, Jujie Sun, Fenghao Sun, Ligang Xing, Xiaorong Sun
Summary: By using multiplex immunofluorescence staining, the study found that tumor-infiltrating CD8+ T cells in patients with lymph node metastases in non-small cell lung cancer were in a more dysfunctional state and accompanied by an immunosuppressive microenvironment. This is associated with lymph node metastases and poor prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xiang Zhang, Nan Feng, Bo Wu, Yiping Wei, Wenxiong Zhang
Summary: Lymph node ratio (LNR) is an important prognostic indicator in non-small-cell lung cancer (NSCLC), with higher LNR indicating worse prognosis. This study found that LNR and positive node category have predictive value for prognosis in stage III NSCLC patients.
