期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 30, 页码 8814-8818出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503172
关键词
boron; cyclic intermediates; deoxygenation; diols; silanes
资金
- Max-Planck-Society
- Max-Planck-Institut fur Kohlenforschung
The selective deoxygenation of polyols is a frontier in our ability to harness the stereochemical and structural complexity of natural and synthetic feedstocks. Herein, we describe a highly active and selective boron-based catalytic system for the selective deoxygenation of terminal 1,2-diols at the primary position, a process that is enabled by the transient formation of a cyclic siloxane. The method provides an ideal complement to well-known catalytic asymmetric reactions to prepare synthetically challenging chiral 2-alkanols in nearly perfect enantiomeric excess, as illustrated in a short synthesis of the anti-inflammatory drug (R)-lisofylline.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据