期刊
CHEST
卷 133, 期 1, 页码 236-242出版社
AMER COLL CHEST PHYSICIANS
DOI: 10.1378/chest.07-0262
关键词
airway remodeling; bronchoconstriction; hyperplasia; hypertrophy
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL089409] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R00 HL089409, R00 HL089409-04] Funding Source: Medline
Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in patients with asthma. New evidence, however, suggests that ASM may also orchestrate and perpetuate airway inflammation by promoting the recruitment, activation, and trafficking of inflammatory cells in the airways. This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma.
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