期刊
CHEMSUSCHEM
卷 7, 期 10, 页码 2821-2824出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201402464
关键词
EFactors; green chemistry; microwave chemistry; porphyrins; solvent effects
资金
- CEM corporation for collaboration
- FCT-Portugal
- QREN/FEDER (COMPETE Programa Operacional Factores de Competitividade) [PTDC/QUI-QUI/112913/2009, PEst-OE/QUI/UI0313/2014]
- [SFRH/BD/84146/2012]
- [SFRH/BPD/84619/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/84146/2012] Funding Source: FCT
Water, under microwave irradiation and at a temperature of 473K, reaches pressures above 16bar, being capable to act as catalyst, without the use of organic solvents and oxidants, for meso-substituted porphyrin synthesis. Sustainability of the reaction is proved by E Factor=35 and EcoScale value of 50.5, the highest so far obtained for porphyrin synthesis. Methodology's wide versatility is clearly demonstrated by the good yields obtained for both aryl and alkyl substituted porphyrins. These reaction conditions represent a huge development, not only by using very high concentrations, minimizing organic solvent usage, but also by eradicating toxic expensive solvents and oxidants.
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