Article
Chemistry, Multidisciplinary
Kseniia Titenkova, Alexander D. Shuvaev, Fedor E. Teslenko, Egor S. Zhilin, Leonid L. Fershtat
Summary: Electrochemical synthesis is being used to create new strategies for the assembly of complex organic molecules. However, forming N-N bonds electrochemically is still challenging due to the electronegativity of nitrogen and side reactions. In this study, a green electrochemical approach was presented to selectively form N-N bonds using oximinohydrazones. The resulting 1,2,3-triazole 1-oxides possess thermally stability and show promise for the development of functional organic materials and pharmaceutical ingredients.
Article
Engineering, Environmental
Ga-Yoon Kim, Jeongbin Lee, Yeo-Jin Rho, Woo-Hee Kim, MinJoong Kim, Ji-Hoon Ahn, Woo-Hee Ryu
Summary: This study examines the synthesis and application potential of heterogeneous rhenium oxide and sulfide nanostructures as electrocatalysts in various electrochemical half-cell reactions. The study demonstrates that the phase composition of the catalyst can be tuned by temperature, optimizing its catalytic activities for hydrogen evolution and oxygen reduction reactions. The research provides a basis for developing efficient catalyst alternatives for sustainable energy conversion and storage systems.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Purushothaman Rajeshwaran, Jonathan Trouve, Khalil Youssef, Rafael Gramage-Doria
Summary: The Wacker reaction is a significant industrial transformation that oxidizes olefins to ketones. However, it typically requires expensive palladium catalysts, which has led to the development of Wacker-type processes that avoid their use, allowing for more sustainable procedures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V. Martin, Ricardo Zavarce, Michal Babiak, Jiri Novacek, Frederick Hartung, Katharina M. Rolfes, Thomas Haarmann-Stemmann, Rodolfo Lavilla
Summary: The participation of reactants in polarity inversion allows the continuation of productive domino processes in multicomponent reactions, leading to the discovery of novel reaction pathways and various polyheterocyclic scaffolds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Jose D. Fuentes, Tobias Gerken, Marcelo Chamecki, Paul Stoy, Livia Freire, Jesus Ruiz-Plancarte
Summary: This study investigates the temporal and spatial patterns of isoprene and monoterpenes emitted by a rainforest in the central Amazon region of Brazil using field experiments and numerical simulations. The results show that the emission and dispersion dominate the isoprene budget, while in a region limited by nitrogen oxides, in-canopy chemical reactions remove approximately 10% of locally emitted monoterpenes.
ATMOSPHERIC ENVIRONMENT
(2022)
Review
Chemistry, Multidisciplinary
Kai Wang, Chen Han, Zongping Shao, Jieshan Qiu, Shaobin Wang, Shaomin Liu
Summary: This review comprehensively elaborates the advances of perovskite oxides in advanced oxidation processes (AOPs) for water remediation, providing insights into their performance, structure, and tuning methods. Strategies for designing novel perovskite oxides to enhance catalytic activities in AOPs have been highlighted.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Organic
Jacob C. Hood, Maksim V. Anokhin, Douglas A. Klumpp
Summary: N-Heterocyclic alcohols have been proven to be excellent substrates for superacid-promoted Friedel-Crafts reactions. The ionization of N-heterocyclic alcohols produces reactive, dicationic intermediates, leading to good to excellent yields of arylation products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chaohuang Chen, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker
Summary: The synthesis of element-carbon double bonds is described in this passage, focusing on the reactions with various molecules to form annulated heterocycles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Luo Yu, Jiayong Xiao, Chuqiang Huang, Zhongshuo Zhang, Ming Qiu, Ying Yu, Ying Wang, Jimmy C. Yu
Summary: This paper presents an ultrafast room-temperature method to convert bimetallic CoNi metal-organic frameworks (MOFs) into high-performance OER catalysts consisting of Fe incorporating CoNi hydroxides and MOFs. The Fe-CoNi MOFs catalyst exhibits excellent OER activity with low overpotential and high turnover frequency, along with superior durability. In situ formed metal oxyhydroxides on the catalyst surface and the regulated electronic configurations by incorporated Fe contribute to the enhanced OER performance.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Kexin Wang, Yali Wang, Bin Yang, Zhongjian Li, Xuetao Qin, Qinghua Zhang, Lecheng Lei, Ming Qiu, Gang Wu, Yang Hou
Summary: Designing acid-stable oxygen evolution reaction (OER) electrocatalysts with low noble-metal content is crucial for green hydrogen generation. In this study, a rutile-structured ruthenium-manganese solid solution oxide with oxygen vacancies (Mn0.73Ru0.27O2-delta) was developed using an electron-feeding modulation strategy. The catalyst exhibited optimal electronic structure and enhanced electrical conductivity, leading to low overpotential and improved OER kinetics. The incorporation of Mn components and O vacancies modulated the adsorption and desorption energy barriers, improving the overall OER kinetics.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Engineering, Chemical
Preetha Chandrasekharan Meenu, Saraswati Roy, Chanchal Chakraborty, Sounak Roy
Summary: This review focuses on the mechanism and efficiency of methanol oxidation reaction and oxygen evolution reaction over structured oxides, emphasizing the potential applications of these two reactions on non-noble metal catalysts.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chenyue Sun, Luming Yang, Manuel A. Ortuno, Ashley M. Wright, Tianyang Chen, Ashley R. Head, Nuria Lopez, Mircea Dinca
Summary: This study investigates the gas-solid reaction of nitric oxide with the metal-organic framework Cu-I-ZrTpmC* and identifies an unusual chelating N2O2.- intermediate using in situ spectroscopies and density functional theory simulations. The results highlight the advantage of site-isolation in metal-organic frameworks (MOFs) for studying important reaction intermediates and provide a mechanistic scenario compatible with the proposed one-electron couple in these enzymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Philipp Schmid, Gasper Jost, Xaver Grass, Didier Touraud, Olivier Diat, Arno Pfitzner, Pierre Bauduin
Summary: In recent years, photoredox chemistry has been extensively studied for its sustainability and low energy consumption. This study introduces a concept called {2-phases 2-reactions 1-catalyst}, which allows two chemical reactions to be performed simultaneously with only one catalyst in a liquid-liquid biphasic system. The concept demonstrates a powerful and sustainable approach to coupling diverse photo-oxidation/reduction reactions, with the advantage of using one reactor and one catalyst.
Article
Chemistry, Multidisciplinary
Hui Zheng, Ziwei Ma, Yunxia Liu, Yizhe Zhang, Jinyu Ye, Elke Debroye, Longsheng Zhang, Tianxi Liu, Yi Xie
Summary: In this study, an oxygen-vacancy-enriched perovskite oxide was synthesized and explored as an electrocatalyst for the NOR process. The results showed high Faradaic efficiency and yield rate, which were correlated with the amount of oxygen vacancies. Theoretical simulations revealed that the presence of oxygen vacancies can decrease the thermodynamic barrier for the NOR reaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Stephan P. Blum, Christean Nickel, Lukas Schaffer, Tarik Karakaya, Siegfried R. Waldvogel
Summary: This study demonstrates the electrochemical aromatic nitration using NBu4NO2 as the nitro source, with 1,1,1-3,3,3-hexafluoroisopropan-2-ol (HFIP) in MeCN significantly increasing the yield by solvent control. The reaction is scalable and shows yields of up to 88%.
Article
Chemistry, Inorganic & Nuclear
Camilla Matassini, Marco Bonanni, Marco Marradi, Stefano Cicchi, Andrea Goti
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Camilla Matassini, Julia Warren, Wang Bo, Andrea Goti, Francesca Cardona, Amelia Morrone, Mikael Bols
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Biochemistry & Molecular Biology
F. Clemente, C. Matassini, C. Faggi, S. Giachetti, C. Cresti, A. Morrone, P. Paoli, A. Goti, M. Martinez-Bailen, F. Cardona
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Debora Pratesi, Camilla Matassini, Andrea Goti, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran, Rolando Spanevello, Francesca Cardona
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Biochemistry & Molecular Biology
Camilla Matassini, Camilla Parmeggiani, Francesca Cardona
Article
Biochemistry & Molecular Biology
Maria Giulia Davighi, Francesca Clemente, Camilla Matassini, Amelia Morrone, Andrea Goti, Macarena Martinez-Bailen, Francesca Cardona
Article
Chemistry, Organic
Debora Pratesi, Andrea Sodini, Camilla Matassini, Francesca Cardona, Andrea Angeli, Fabrizio Carta, Marta Ferraroni, Claudiu T. Supuran, Andrea Goti
Summary: Synthesis of twelve new aza-sugar-benzenesulfonamides by connecting benzenesulfonamides to a triazole armed aza-sugar resulted in significant effects on the inhibition profile of human carbonic anhydrases. Some new compounds demonstrated selective inhibitory effects, with four of them showing particular efficacy on therapeutically relevant hCAs II and VII isoforms.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Francesca Clemente, Camilla Matassini, Sara Giachetti, Andrea Goti, Amelia Morrone, Macarena Martinez-Bailen, Sara Orta, Pedro Merino, Francesca Cardona
Summary: A straightforward synthetic strategy was reported for preparing trihydroxypiperidine azasugars as potential inhibitors of the lysosomal enzyme glucocerebrosidase. The best ligand for GCase, compound 15, was obtained in remarkable yields through a series of reactions starting from low-cost D-mannose. MD simulations helped identify the chair conformation with the best binding affinity.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Costanza Vanni, Anne Bodlenner, Marco Marradi, Jeremy P. Schneider, Maria de los Angeles Ramirez, Sergio Moya, Andrea Goti, Francesca Cardona, Philippe Compain, Camilla Matassini
Summary: In this study, water dispersible gold nanoparticles coated with iminosugar deoxynojirimycin (DNJ) and simple monosaccharides were prepared, leading to enhanced inhibitory activity towards Jack bean alpha-mannosidase. A novel strategy involving longer amphiphilic linker and trimeric presentation of the inhitope was employed, resulting in a significant increase in inhibitory potency.
Editorial Material
Biochemistry & Molecular Biology
Francesca Cardona, Camilla Parmeggiani, Camilla Matassini
Article
Biochemistry & Molecular Biology
Elena Petricci, Simone Zurzolo, Camilla Matassini, Samuele Maramai, Francesca Cardona, Andrea Goti, Maurizio Taddei
Summary: A general method for the synthesis of pyrrolizidine derivatives using intramolecular hydroaminomethylation protocol under microwave dielectric heating is reported. The use of ethanol as a solvent provides environmentally friendly conditions, and the ligand/catalyst system can be recycled without significant impact on yield.
Review
Chemistry, Medicinal
Macarena Martinez-Bailen, Francesca Clemente, Camilla Matassini, Francesca Cardona
Summary: Pharmaceutical chaperones (PCs) are small compounds that can bind and stabilize misfolded proteins, helping them regain their native conformation and biological activity. They are especially beneficial in treating lysosomal storage disorders (LSDs) caused by genetic mutations. However, despite the importance of the GCase enzyme in treating LSDs and neurological disorders, no PC for this enzyme has been approved for market use. This review highlights the efforts made in the past 7 years to identify new PCs for the GCase enzyme, with a focus on glycomimetic-based compounds.
Article
Chemistry, Organic
Paolo Della Sala, Costanza Vanni, Carmen Talotta, Luca Di Marino, Camilla Matassini, Andrea Goti, Placido Neri, Sergej Sestak, Francesca Cardona, Carmine Gaeta
Summary: The synthesis of multivalent ligands anchored to resorcinarene scaffolds showed significant multivalent effects towards GMIIb, a recombinant Drosophila homolog of over-expressed human Golgi alpha-mannosidase II, indicating promising inhibitory potency. Computational studies helped to understand the origin of the multivalent effect and the relative inhibitory potency of the new architectures.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Stefania Mirabella, Giulia Petrucci, Cristina Faggi, Camilla Matassini, Francesca Cardona, Andrea Goti