期刊
CHEMPHYSCHEM
卷 15, 期 18, 页码 4100-4107出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201402607
关键词
hyperpolarization; iridium; NMR spectroscopy; molecular imaging; SABRE
资金
- Russian Science Foundation [14-13-00445]
- National Institutes of Health (NIH) [5R00 CA134749-03, 3R00 A134749-02S1]
- DoD Congressionally Directed Medical Research Programs Breast Cancer Program Era of Hope Award [W81XWH-12-1-0159/BC112431]
- National Science Foundation [CHE-1416268]
- Russian Foundation for Basic Research [14-03-93183 MCX a]
- Russian Science Foundation [14-13-00445] Funding Source: Russian Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416268, 1416432] Funding Source: National Science Foundation
By using 5.75 and 47.5 mT nuclear magnetic resonance (NMR) spectroscopy, up to 10(5)-fold sensitivity enhancement through signal amplification by reversible exchange (SABRE) was enabled, and subsecond temporal resolution was used to monitor an exchange reaction that resulted in the buildup and decay of hyperpolarized species after parahydrogen bubbling. We demonstrated the high-resolution low-field proton magnetic resonance imaging (MRI) of pyridine in a 47.5 mT magnetic field endowed by SABRE. Molecular imaging (i.e. imaging of dilute hyperpolarized substances rather than the bulk medium) was conducted in two regimes: in situ real-time MRI of the re-action mixture (in which pyridine was hyperpolarized), and ex situ MRI (in which hyperpolarization decays) of the liquid hyperpolarized product. Low-field (milli-Tesla range, e.g. 5.75 and 47.5 mT used in this study) parahydrogen-enhanced NMR and MRI, which are free from the limitations of high-field magnetic resonance (including susceptibility-induced gradients of the static magnetic field at phase interfaces), potentially enables new imaging applications as well as differentiation of hyperpolarized chemical species on demand by exploiting spin manipulations with static and alternating magnetic fields.
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