Article
Chemistry, Multidisciplinary
Xiujuan Shi, Jun Zhang, Junkai Liu, Xueqian Zhao, Haoran Wang, Peifa Wei, Xiaodong Zhang, Xin-Long Ni, Herman H-Y Sung, Ian D. Williams, Wai Kit Ng, Kam Sing Wong, Jacky W. Y. Lam, Lin Wang, Honglin Jin, Ben Zhong Tang
Summary: In this study, a hierarchical supramolecular self-assembly method was proposed for the fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks using CB[8], NaBr, and AIEgen guests.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Ruslan Kashapov, Yuliya Razuvayeva, Albina Ziganshina, Anastasiia Sapunova, Anna Lyubina, Syumbelya Amerhanova, Natalia Kulik, Alexandra Voloshina, Irek Nizameev, Vadim Salnikov, Lucia Zakharova
Summary: The study found that the self-assembly of synthesized macrocycles is mainly driven by hydrophobic interactions of their hydrophobic chains and π-π stacking interactions between aromatic rings. Long-chain viologen macrocycles not only have low hemotoxicity and selective cytotoxic activity, but also can bind therapeutic molecules, making them promising drug nanocontainers.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemical Research Methods
Asma Rahali, Ahmed Shaukat, Veronica Almeida-Marrero, Bassem Jamoussi, Andres de la Escosura, Tomas Torres, Mauri A. Kostiainen, Eduardo Anaya-Plaza
Summary: By designing and synthesizing multifunctional phthalocyanine dyes, aggregation can be prevented, allowing them to adhere to DNA origami nanostructures and stabilize the structures. This approach provides insight into the design and synthesis of Janus-type sensitizers that can be combined with biomolecules to form optically active biohybrids.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xianglian Li, Hui Liu, Ailing Yu, Dan Lin, Zhishu Bao, Yuqin Wang, Xingyi Li
Summary: The newly designed NapFFKKFKLKL/Dexp supramolecular hydrogel displayed controlled drug release behavior, good intraocular biocompatibility, and potent anti-inflammatory capacity, making it a promising drug carrier system for treating posterior disorders such as uveitis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Biomedical
Qiuhui Qian, Dali Wang, Leilei Shi, Zhihao Zhang, Jiwen Qian, Jian Shen, Chunyang Yu, Xinyuan Zhu
Summary: Local drug delivery systems, particularly hydrogels, have shown great potential in preventing postoperative tumor recurrence. However, their clinical translation has been hindered by the need for chemical modification or additional carrier molecules. A newly developed pure molecular anticancer drug hydrogel has demonstrated effectiveness in reducing tumor recurrence rates and could serve as a powerful tool in preventing postoperative local tumor recurrence.
Review
Biochemistry & Molecular Biology
Manuela Stefanelli, Gabriele Magna, Corrado Di Natale, Roberto Paolesse, Donato Monti
Summary: Conjugating the porphyrin ring with an amino acid via amide linkage allows for the creation of both amphiphilicity and chirality in the macrocycle. The use of proline residue is advantageous due to its conformational rigidity, which allows for efficient transfer and amplification of molecular chirality in aqueous environments. This article describes the evolution of studies conducted by the authors to achieve chiral systems from porphyrin-proline derivatives, both in solution and in the solid state. The discussion focuses on fundamental aspects that influence the resulting molecular architectures, including the nature of the appended group, the presence of coordinated metal ions, and the properties of the solvent. The fine-tuning of these parameters enables the creation of stereospecific structures with distinct chiroptical and morphological features. Solid films based on these chiral systems are also obtained and their recognition abilities in gaseous and liquid phases are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ya Zhang, Xiao-Yu Zhang, Kai Chen, Wei-Yin Sun
Summary: In this study, a nanocomposite catalyst formed by modifying Cu2O with Q[6] exhibited high efficiency and selectivity in the electrochemical reduction of CO2. The strong CO2 adsorption capacity and hydrophobic nature of Q[6] contributed to the improvements in catalytic performance for CO2RR.
Article
Chemistry, Multidisciplinary
Carmen C. Piras, Anna K. Patterson, David K. Smith
Summary: This study describes the fabrication of new pH-responsive hybrid gel beads and explores the impact of different gelator combinations on drug release performance. By controlling the formulation of gel beads, drug release under different pH conditions can be achieved. These gel beads show promising potential for controlled drug delivery applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Multidisciplinary Sciences
Kelsey G. DeFrates, Joakim Engstrom, Nivedina A. Sarma, Athiyya Umar, Jisoo Shin, Jing Cheng, Weiran Xie, Darrin Pochan, Ahmad K. Omar, Phillip B. Messersmith
Summary: Supramolecular self-assemblies have been widely used for drug delivery, but the encapsulation efficiency and release kinetics are limited. In this study, amphiphilic prodrugs based on poly(ethylene glycol) and a proregenerative drug were designed and synthesized to overcome these limitations. The physical state of the prodrugs in water and the release and cellular transport of the drug were found to be strongly influenced by the molecular architecture and the hydrophobic-to-hydrophilic ratio of the conjugates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Keigo Tashiro, Takuho Saito, Hironari Arima, Natsuki Suda, Balaraman Vedhanarayanan, Shiki Yagai
Summary: Chemists have constructed sophisticated artificial nanostructured systems through self-assembly, including scissor-shaped photochromic dyads that hierarchically self-assemble into discrete nanostructures with photoresponsive properties. These nanostructures, such as azobenzene dyads, can be dissociated and reorganized through the photoisomerization of azobenzene units, enabling controllable and adjustable structures.
Article
Chemistry, Multidisciplinary
Ikuya Matsumoto, Ryo Sekiya, Takeharu Haino
Summary: By decorating nanographenes with alkyl chains and controlling concentration, solvent polarity, temperature, and sonication, it is possible to achieve self-assembly and formation of stacked structures. Optical measurements and AFM images confirm the presence of stacked structures, while molecular mechanics calculations model the interactions within the aggregates. The nanographenes exhibit concentration-dependent morphologies, forming stacked structures at low concentrations and polymer-like network structures at higher concentrations on mica.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Selina Hollstein, Lamiaa M. A. Ali, Maeva Coste, Julian Vogel, Nadir Bettache, Sebastien Ulrich, Max von Delius
Summary: The increased importance of RNA-based therapeutics requires the development of next-generation stimuli-responsive systems for binding, transporting, and releasing RNA oligomers. In this study, we present triazolium-based amphiphiles capable of binding siRNA and enzyme-responsive release of the nucleic acid payload. These amphiphiles self-assemble into nanocarriers that can disintegrate in the presence of esterase. The molecular design includes a self-immolative linker anchored to the triazolium moiety, which acts as a positively-charged polar head group. Esterase triggers a cascade degradation of the linker, resulting in the release of the negatively-charged siRNA. This molecular design and approach are promising for various applications beyond this proof-of-principle study, thanks to efficient CuAAC click chemistry and mild esterase cleavage.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sylvain Sudan, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Kristina E. Ebbert, Guido H. Clever, Kay Severin
Summary: Thirteen palladium-ligand assemblies with different structures and topologies were studied for their ability to bind lithium ions. It was found that the addition of LiBF4 caused a significant structural rearrangement in one case, converting a dinuclear [Pd2L4](4+) complex into a low-symmetry [Pd4L8](8+) assembly with two binding pockets for solvated LiBF4 ion pairs. This rearrangement was only induced by Li+, indicating highly specific host-guest interactions. Structural analysis revealed that the [Pd4L8](8+) receptor had a compact structure with multiple intramolecular interactions, similar to natural and synthetic foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Bo Yang, Shang-Bo Yu, Pan-Qing Zhang, Ze-Kun Wang, Qiao-Yan Qi, Xu-Qing Wang, Xun-Hui Xu, Hai-Bo Yang, Zong-Quan Wu, Yi Liu, Da Ma, Zhan-Ting Li
Summary: Accurately controlling the layer number of orderly stacked 2D polymers remains a challenge in self-assembly. In this study, a bilayer 2D supramolecular organic framework was fabricated from a monolayer framework in water through cooperative coordination, showing structural regularity in both solution and solid state, with the bilayer character selectively realized on the micrometer scale.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Ruslan Kashapov, Yuliya Razuvayeva, Nadezda Kashapova, Albina Ziganshina, Vadim Salnikov, Anastasiia Sapunova, Alexandra Voloshina, Lucia Zakharova
Summary: This study reports a simple method for the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family, resulting in the formation of nanosized particles. The self-assembly of these nanoparticles was achieved through cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are capable of binding various hydrophobic and hydrophilic drugs, leading to enhanced cytotoxic properties. This work demonstrates the promising route to bottom-up assembly of novel supramolecular soft matter by utilizing the intermolecular interactions between flexible RNA and rigid calixarene, expanding the design possibilities of nanoscale drug carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
